Search Results - "Hall, Garth F"

Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease by Saman, Sudad, Kim, WonHee, Raya, Mario, Visnick, Yvonne, Miro, Suhad, Saman, Sarmad, Jackson, Bruce, McKee, Ann C., Alvarez, Victor E., Lee, Norman C.Y., Hall, Garth F.

“…Recent demonstrations that the secretion, uptake, and interneuronal transfer of tau can be modulated by disease-associated tau modifications suggest that…”
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Tangles, Toxicity, and Tau Secretion in AD - New Approaches to a Vexing Problem by Gendreau, Kerry L, Hall, Garth F

“…When the microtubule (MT)-associated protein tau is not bound to axonal MTs, it becomes hyperphosphorylated and vulnerable to proteolytic cleavage and other…”
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Interneuronal transfer of human tau between Lamprey central neurons in situ by Kim, Wonhee, Lee, Sangmook, Jung, Cheolwha, Ahmed, Ambar, Lee, Gloria, Hall, Garth F

“…The mechanisms by which tau-containing lesions are propagated between adjacent and synaptically interconnected parts of the brain are a potentially important…”
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Accumulation of Vesicle-Associated Human Tau in Distal Dendrites Drives Degeneration and Tau Secretion in an In Situ Cellular Tauopathy Model by Hall, Garth F., Li, Zhihan, Kim, WonHee, Lee, Sangmook

“…We used a nontransgenic cellular tauopathy model in which individual giant neurons in the lamprey CNS (ABCs) overexpress human tau isoforms cell autonomously…”
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Is tau ready for admission to the prion club? by Hall, Garth F., Patuto, Brian A.

“…Aggregation-prone proteins associated with neurodegenerative disease, such as α synuclein and β amyloid, now appear to share key prion-like features with…”
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Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model by Tagge, Chad A, Fisher, Andrew M, Minaeva, Olga V, Gaudreau-Balderrama, Amanda, Moncaster, Juliet A, Zhang, Xiao-Lei, Wojnarowicz, Mark W, Casey, Noel, Lu, Haiyan, Kokiko-Cochran, Olga N, Saman, Sudad, Ericsson, Maria, Onos, Kristen D, Veksler, Ronel, Senatorov, Vladimir V, Kondo, Asami, Zhou, Xiao Z, Miry, Omid, Vose, Linnea R, Gopaul, Katisha R, Upreti, Chirag, Nowinski, Christopher J, Cantu, Robert C, Alvarez, Victor E, Hildebrandt, Audrey M, Franz, Erich S, Konrad, Janusz, Hamilton, James A, Hua, Ning, Tripodis, Yorghos, Anderson, Andrew T, Howell, Gareth R, Kaufer, Daniela, Hall, Garth F, Lu, Kun P, Ransohoff, Richard M, Cleveland, Robin O, Kowall, Neil W, Stein, Thor D, Lamb, Bruce T, Huber, Bertrand R, Moss, William C, Friedman, Alon, Stanton, Patric K, McKee, Ann C, Goldstein, Lee E

“…The mechanisms underpinning concussion, traumatic brain injury (TBI) and chronic traumatic encephalopathy (CTE) are poorly understood. Using neuropathological…”
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Secretion of human tau fragments resembling CSF-tau in Alzheimer’s disease is modulated by the presence of the exon 2 insert by Kim, WonHee, Lee, Sangmook, Hall, Garth F.

“…Abnormal tau cleavage is prominent in the neurofibrillary degeneration characteristic of Alzheimer’s disease (AD) and related tauopathies. We recently showed…”
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Small-Molecule Mediated Neuroprotection in an In Situ Model of Tauopathy by Honson, Nicolette S., Jensen, Jordan R., Abraha, Aida, Hall, Garth F., Kuret, Jeff

“…Small-molecule inhibitors of neurofibrillary lesion formation may have utility for treatment of Alzheimer’s disease and certain forms of frontotemporal lobar…”
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Proteins recruited to exosomes by tau overexpression implicate novel cellular mechanisms linking tau secretion with Alzheimer's disease by Saman, Sudad, Lee, Norman C Y, Inoyo, Itoro, Jin, Jun, Li, Zhihan, Doyle, Thomas, McKee, Ann C, Hall, Garth F

“…Tau misprocessing to form aggregates and other toxic species has emerged as a major feature in our developing understanding of the etiology and pathogenesis of…”
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Human Tau Becomes Phosphorylated and Forms Filamentous Deposits When Overexpressed in Lamprey Central Neurons in situ by Hall, Garth F., Yao, Jun, Lee, Gloria

“…Microinjection of plasmids encoding human tau (htau) protein into identified lamprey reticulospinal neurons (anterior bulbar cells, or ABCs) in situ induces…”
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Death or secretion? The demise of a plausible assumption about CSF-tau in Alzheimer Disease? by Hall, Garth F., Saman, Sudad

“…Our recent identification of an exosomal route for tau protein secretion 1 marks a key similarity between tau and other aggregation-prone proteins implicated…”
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Potentiation of tau aggregation by cdk5 and GSK3β by Lee, Sangmook, Hall, Garth F, Shea, Thomas B

“…Hyperphosphorylation of tau is closely associated with its aggregation by as yet undefined mechanisms. We attempted herein to further investigate the…”
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Tau secretion to the extracellular space is modulated by the presence of the exon 2 alternatively spliced insert in cell culture and in situ tauopathy models by Hall, Garth F, WonHee Kim, Lee, Sangmook

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Multiple mechanisms of extracellular tau spreading in a non-transgenic tauopathy model by Le, Meghan N, Kim, Wonhee, Lee, Sangmook, McKee, Ann C, Hall, Garth F

“…While the interneuronal propagation of neurofibrillary lesions in Alzheimer's disease and other tauopathies now appears to involve the spreading of…”
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EARLY CHRONIC TRAUMATIC ENCEPHALOPATHY IN YOUNG ATHLETES AFTER CONCUSSIVE CLOSED-HEAD IMPACT INJURY AND MOUSE MODEL OF IMPACT CONCUSSION by Goldstein, Lee E, Tagge, Chad A, Fisher, Andrew M, Minaeva, Olga, Gaudreau, Amanda, Zhang, Xiao-Lei, Upreti, Chirag, Ericsson, Maria, Wojnarowicz, Mark W, Casey, Noel F, Moncaster, Juliet A, Nowinski, Christopher, Cantu, Robert, Saman, Sudad, Hall, Garth F, Alvarez, Victor E, Kondo, Asami, Anderson, Andy, Veksler, Ronel, Onos, Kristen, Lu, Haiyan, Senatorov, Vlad, Huber, Bertrand R, Stein, Thor D, Tripodis, Yorghos, Kaufer, Daniela, Lu, Kun Ping, Cleveland, Robin O, Howell, Gareth, Friedman, Alon, Ransohoff, Richard, Lamb, Bruce T, Moss, William C, Stanton, Patric K, McKee, Ann C

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Exonic point mutations of human tau enhance its toxicity and cause characteristic changes in neuronal morphology, tau distribution and tau phosphorylation in the lamprey cellular model of tauopathy by Lee, Sangmook, Jung, Cheolwha, Lee, Gloria, Hall, Garth F

“…Exonic mutations in the gene coding for human tau cause familial neurofibrillary degenerative diseases (tauopathies) which exhibit mutation-specific…”
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O4-01-04: Mitochondrial clumping is a central feature in the Tau neurodegeneration mechanism in an in situ tauopathy model by Hall, Garth F, Lee, Sangmook, Ferreira, Adriana, Lee, Gloria

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Modeling tauopathy: a range of complementary approaches by Hall, Garth F., Yao, Jun

“…The large group of neurodegenerative diseases which feature abnormal metabolism and accumulation of tau protein (tauopathies) characteristically produce a…”
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The glutamate-rich region of the larger lamprey neurofilament sidearm is essential for proper neurofilament architecture by Lee, Sangmook, Chu, Boyang, Yao, Jun, Shea, Thomas B, Hall, Garth F

“…Abstract The carboxyl terminal “tail” domains of the heavy and middle molecular weight mammalian neurofilament (NF) proteins regulate inter-NF spacing and…”
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Human tau filaments induce microtubule and synapse loss in an in vivo model of neurofibrillary degenerative disease by Hall, G F, Chu, B, Lee, G, Yao, J

“…The intracellular accumulation of tau protein and its aggregation into filamentous deposits is the intracellular hallmark of neurofibrillary degenerative…”
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