Search Results - "Hall, Dennis"

Boronic Acids as Bioorthogonal Probes for Site‐Selective Labeling of Proteins by Akgun, Burcin, Hall, Dennis G.

“…Over the past two decades, bioorthogonal chemistry has become a preferred tool to achieve site‐selective modifications of proteins. However, there are only a…”
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Stereodivergent Asymmetric Synthesis of α,β-Disubstituted β‑Aminoalkylboronic Acid Derivatives via Group-Selective Protodeboronation Enabling Access to the Elusive Anti Isomer by Li, Xiangyu, Hall, Dennis G

“…Chiral β-aminoalkylboronates generate growing interest as versatile synthetic building blocks to access β-aminoalcohols and other useful compounds, and also as…”
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Diastereocontrolled Monoprotodeboronation of β‐Sulfinimido gem‐Bis(boronates): A General and Stereoselective Route to α,β‐Disubstituted β‐Aminoalkylboronates by Li, Xiangyu, Hall, Dennis G.

“…β‐Aminoalkylboronic acids are bioisosteres of the pharmaceutically important class of β‐amino acids but few stereoselective methods exist for their…”
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Multicomponent Hetero-[4 + 2] Cycloaddition/Allylboration Reaction: From Natural Product Synthesis to Drug Discovery by Hall, Dennis G, Rybak, Taras, Verdelet, Tristan

“…Multicomponent reactions (MCR), transformations employing three or more simple substrates in a single and highly atom-economical operation, are very attractive…”
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Dual Catalysis Using Boronic Acid and Chiral Amine: Acyclic Quaternary Carbons via Enantioselective Alkylation of Branched Aldehydes with Allylic Alcohols by Mo, Xiaobin, Hall, Dennis G

“…A ferrocenium boronic acid salt activates allylic alcohols to generate transient carbocations that react with in situ-generated chiral enamines from branched…”
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Synthesis and Applications of β‐Aminoalkylboronic Acid Derivatives by Li, Xiangyu, Hall, Dennis G.

“…α‐Aminoalkylboronic acids display a distinct role in medicinal chemistry, and their utility has been demonstrated by the successful commercialization of three…”
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Peptidomimetics via modifications of amino acids and peptide bonds by Avan, Ilker, Hall, C Dennis, Katritzky, Alan R

“…Peptidomimetics represent an important field in chemistry, pharmacology and material science as they circumvent the limitations of traditional peptides used in…”
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Natural Product Synthesis Using Multicomponent Reaction Strategies by Touré, Barry B, Hall, Dennis G

“…Multicomponent reaction strategies were developed for the synthesis of complex natural products. The use of multicomponent reaction strategies for the…”
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Fast and Tight Boronate Formation for Click Bioorthogonal Conjugation by Akgun, Burcin, Hall, Dennis G.

“…A new click bioorthogonal reaction system was devised to enable the fast ligation (kON≈340 m−1 s−1) of conjugatable derivatives of a rigid cyclic diol…”
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Enantioselective preparation and chemoselective cross-coupling of 1,1-diboron compounds by Lee, Jack Chang Hung, McDonald, Robert, Hall, Dennis G.

“…The simplicity, efficiency and generality of the transition-metal-catalysed Suzuki–Miyaura cross-coupling reaction has led to its application in the…”
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Direct Boronic Acid Promoted Amidation of Carboxylic Acids with Poorly Nucleophilic Amines by Zhou, Jingning, Paladino, Marco, Hall, Dennis G.

“…Direct amidation of carboxylic acids with poorly nucleophilic amines such as anilines is a notorious challenge in organic chemistry. Previously reported…”
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Design, Synthesis, and Screening of a Library of Peptidyl Bis(Boroxoles) as Oligosaccharide Receptors in Water: Identification of a Receptor for the Tumor Marker TF-Antigen Disaccharide by Pal, Arnab, Bérubé, Marie, Hall, Dennis G

“…Mini lectins: A new class of oligosaccharide receptors (see example) was designed by exploiting several modes of molecular recognition, including the unique…”
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Direct Amidation of Carboxylic Acids Catalyzed by ortho-Iodo Arylboronic Acids: Catalyst Optimization, Scope, and Preliminary Mechanistic Study Supporting a Peculiar Halogen Acceleration Effect by Gernigon, Nicolas, Al-Zoubi, Raed M, Hall, Dennis G

“…The importance of amides as a component of biomolecules and synthetic products motivates the development of catalytic, direct amidation methods employing free…”
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Injectable Self-Healing Zwitterionic Hydrogels Based on Dynamic Benzoxaborole–Sugar Interactions with Tunable Mechanical Properties by Chen, Yangjun, Wang, Wenda, Wu, Di, Nagao, Masanori, Hall, Dennis G, Thundat, Thomas, Narain, Ravin

“…Dynamic hydrogels based on arylboronic esters have been considered as ideal platforms for biomedical applications given their self-healing and injectable…”
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Multiresponsive and Self-Healing Hydrogel via Formation of Polymer–Nanogel Interfacial Dynamic Benzoxaborole Esters at Physiological pH by Chen, Yangjun, Wang, Wenda, Wu, Di, Zeng, Hongbo, Hall, Dennis G, Narain, Ravin

“…Nanocomposite hydrogels with multiresponsiveness and self-healing property are attracting extensive interest due to their enhanced performance for a wide range…”
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Divergent Synthesis of 1,2,3,4‐Tetrasubstituted Cyclobutenes from a Common Scaffold: Enantioselective Desymmetrization by Dual‐Catalyzed Photoredox Cross‐Coupling by Konowalchuk, Dawson J., Hall, Dennis G.

“…Four‐membered carbocycles are important structural motifs found in several natural products and drugs. Amongst those, cyclobutenes are attractive intermediates…”
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Suppressing Protodeboronation in Cu‐Mediated 19F/18F‐Fluorination of Arylboronic Acids: A Mechanistically Guided Approach Towards Optimized PET Probe Development by Sun, Jingkai, Jaworski, Carolin, Schirrmacher, Ralf, Hall, Dennis G.

“…Fluorinated arenes play a crucial role in drug discovery, specialty materials, and medical imaging. Although several variants for Cu‐mediated nucleophilic…”
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Bioinspired Self-Healing Hydrogel Based on Benzoxaborole-Catechol Dynamic Covalent Chemistry for 3D Cell Encapsulation by Chen, Yangjun, Diaz-Dussan, Diana, Wu, Di, Wang, Wenda, Peng, Yi-Yang, Asha, Anika Benozir, Hall, Dennis G, Ishihara, Kazuhiko, Narain, Ravin

“…Boronic ester, one typical example of dynamic covalent bonds, has presented great potential to prepare self-healing hydrogels. However, most of currently…”
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Direct nucleophilic and electrophilic activation of alcohols using a unified boron-based organocatalyst scaffold by Rygus, Jason P. G., Hall, Dennis G.

“…Organocatalytic strategies for the direct activation of hydroxy-containing compounds have paled in comparison to those applicable to carbonyl compounds. To…”
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In Situ Forming, Dual-Crosslink Network, Self-Healing Hydrogel Enabled by a Bioorthogonal Nopoldiol–Benzoxaborolate Click Reaction with a Wide pH Range by Wu, Di, Wang, Wenda, Diaz-Dussan, Diana, Peng, Yi-Yang, Chen, Yangjun, Narain, Ravin, Hall, Dennis G

“…The use of click chemistry as a hydrogel cross-linking reaction is often limited by slow reaction rates and harsh conditions, such as exposure to UV light…”
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