Search Results - "Hall, Dawn L."

Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40 by Lu, Jun, Byrne, Noel, Wang, John, Bricogne, Gerard, Brown, Frank K, Chobanian, Harry R, Colletti, Steven L, Di Salvo, Jerry, Thomas-Fowlkes, Brande, Guo, Yan, Hall, Dawn L, Hadix, Jennifer, Hastings, Nicholas B, Hermes, Jeffrey D, Ho, Thu, Howard, Andrew D, Josien, Hubert, Kornienko, Maria, Lumb, Kevin J, Miller, Michael W, Patel, Sangita B, Pio, Barbara, Plummer, Christopher W, Sherborne, Bradley S, Sheth, Payal, Souza, Sarah, Tummala, Srivanya, Vonrhein, Clemens, Webb, Maria, Allen, Samantha J, Johnston, Jennifer M, Weinglass, Adam B, Sharma, Sujata, Soisson, Stephen M

“…Crystal structures of hGPR40, a target for treatment of type 2 diabetes, bound to a partial and an allosteric agonist explain the binding cooperativity between…”
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Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation by Hong, Chuan, Byrne, Noel J., Zamlynny, Beata, Tummala, Srivanya, Xiao, Li, Shipman, Jennifer M., Partridge, Andrea T., Minnick, Christina, Breslin, Michael J., Rudd, Michael T., Stachel, Shawn J., Rada, Vanessa L., Kern, Jeffrey C., Armacost, Kira A., Hollingsworth, Scott A., O’Brien, Julie A., Hall, Dawn L., McDonald, Terrence P., Strickland, Corey, Brooun, Alexei, Soisson, Stephen M., Hollenstein, Kaspar

“…Narcolepsy type 1 (NT1) is a chronic neurological disorder that impairs the brain’s ability to control sleep-wake cycles. Current therapies are limited to the…”
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Structural Basis of Human p70 Ribosomal S6 Kinase-1 Regulation by Activation Loop Phosphorylation by Sunami, Tomoko, Byrne, Noel, Diehl, Ronald E., Funabashi, Kaoru, Hall, Dawn L., Ikuta, Mari, Patel, Sangita B., Shipman, Jennifer M., Smith, Robert F., Takahashi, Ikuko, Zugay-Murphy, Joan, Iwasawa, Yoshikazu, Lumb, Kevin J., Munshi, Sanjeev K., Sharma, Sujata

“…p70 ribosomal S6 kinase (p70S6K) is a downstream effector of the mTOR signaling pathway involved in cell proliferation, cell growth, cell-cycle progression,…”
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Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT) by Harrison, Scott T, Poslusney, Michael S, Mulhearn, James J, Zhao, Zhijian, Kett, Nathan R, Schubert, Jeffrey W, Melamed, Jeffrey Y, Allison, Timothy J, Patel, Sangita B, Sanders, John M, Sharma, Sujata, Smith, Robert F, Hall, Dawn L, Robinson, Ronald G, Sachs, Nancy A, Hutson, Pete H, Wolkenberg, Scott E, Barrow, James C

“…3-Hydroxy-4-pyridinones and 5-hydroxy-4-pyrimidinones were identified as inhibitors of catechol-O-methyltransferase (COMT) in a high-throughput screen. These…”
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Structure of Human Prostasin, a Target for the Regulation of Hypertension by Rickert, Keith W., Kelley, Paul, Byrne, Noel J., Diehl, Ronald E., Hall, Dawn L., Montalvo, Allison M., Reid, John C., Shipman, Jennifer M., Thomas, Bradley W., Munshi, Sanjeev K., Darke, Paul L., Su, Hua-Poo

“…Prostasin (also called channel activating protease-1 (CAP1)) is an extracellular serine protease implicated in the modulation of fluid and electrolyte…”
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Structural definition and substrate specificity of the S28 protease family: the crystal structure of human prolylcarboxypeptidase by Soisson, Stephen M, Patel, Sangita B, Abeywickrema, Pravien D, Byrne, Noel J, Diehl, Ronald E, Hall, Dawn L, Ford, Rachael E, Reid, John C, Rickert, Keith W, Shipman, Jennifer M, Sharma, Sujata, Lumb, Kevin J

“…The unique S28 family of proteases is comprised of the carboxypeptidase PRCP and the aminopeptidase DPP7. The structural basis of the different substrate…”
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Insights into activity and inhibition from the crystal structure of human O-GlcNAcase by Elsen, Nathaniel L, Patel, Sangita B, Ford, Rachael E, Hall, Dawn L, Hess, Fred, Kandula, Hari, Kornienko, Maria, Reid, John, Selnick, Harold, Shipman, Jennifer M, Sharma, Sujata, Lumb, Kevin J, Soisson, Stephen M, Klein, Daniel J

“…Crystallographic analysis of human O-GlcNAc hydrolase (hOGA) fragments containing the catalytic domain, including structures in complex with known inhibitors,…”
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Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4 by Allen, Samantha J., Parthasarathy, Gopal, Darke, Paul L., Diehl, Ronald E., Ford, Rachael E., Hall, Dawn L., Johnson, Scott A., Reid, John C., Rickert, Keith W., Shipman, Jennifer M., Soisson, Stephen M., Zuck, Paul, Munshi, Sanjeev K., Lumb, Kevin J.

“…G-protein-coupled receptor (GPCR) kinases (GRKs) bind to and phosphorylate GPCRs, initiating the process of GPCR desensitization and internalization. GRK4 is…”
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Integration of Affinity Selection-Mass Spectrometry and Functional Cell-Based Assays to Rapidly Triage Druggable Target Space within the NF-κB Pathway by Kutilek, Victoria D, Andrews, Christine L, Richards, Matthew P, Xu, Zangwei, Sun, Tianxiao, Chen, Yiping, Hashke, Andrew, Smotrov, Nadya, Fernandez, Rafael, Nickbarg, Elliott B, Chamberlin, Chad, Sauvagnat, Berengere, Curran, Patrick J, Boinay, Ryan, Saradjian, Peter, Allen, Samantha J, Byrne, Noel, Elsen, Nathaniel L, Ford, Rachael E, Hall, Dawn L, Kornienko, Maria, Rickert, Keith W, Sharma, Sujata, Shipman, Jennifer M, Lumb, Kevin J, Coleman, Kevin, Dandliker, Peter J, Kariv, Ilona, Beutel, Bruce

“…The primary objective of early drug discovery is to associate druggable target space with a desired phenotype. The inability to efficiently associate these…”
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Structure of apo, unactivated insulin-like growth factor-1 receptor kinase at 1.5 Å resolution by Munshi, Sanjeev, Hall, Dawn L., Kornienko, Maria, Darke, Paul L., Kuo, Lawrence C.

“…The crystal structure of the wild‐type unactivated kinase domain (IGFRK‐0P) of insulin‐like growth factor‐1 receptor has been reported previously at 2.7 Å…”
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Structural Basis for Selective Small Molecule Kinase Inhibition of Activated c-Met by Rickert, Keith W., Patel, Sangita B., Allison, Timothy J., Byrne, Noel J., Darke, Paul L., Ford, Rachael E., Guerin, David J., Hall, Dawn L., Kornienko, Maria, Lu, Jun, Munshi, Sanjeev K., Reid, John C., Shipman, Jennifer M., Stanton, Elizabeth F., Wilson, Kevin J., Young, Jonathon R., Soisson, Stephen M., Lumb, Kevin J.

“…The receptor tyrosine kinase c-Met is implicated in oncogenesis and is the target for several small molecule and biologic agents in clinical trials for the…”
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Characterization of Non-Nitrocatechol Pan and Isoform Specific Catechol-O-methyltransferase Inhibitors and Substrates by Robinson, Ronald G, Smith, Sean M, Wolkenberg, Scott E, Kandebo, Monika, Yao, Lihang, Gibson, Christopher R, Harrison, Scott T, Polsky-Fisher, Stacey, Barrow, James C, Manley, Peter J, Mulhearn, James J, Nanda, Kausik K, Schubert, Jeffrey W, Trotter, B. Wesley, Zhao, Zhijian, Sanders, John M, Smith, Robert F, McLoughlin, Debra, Sharma, Sujata, Hall, Dawn L, Walker, Tiffany L, Kershner, Jennifer L, Bhandari, Neetesh, Hutson, Pete H, Sachs, Nancy A

“…Reduced dopamine neurotransmission in the prefrontal cortex has been implicated as causal for the negative symptoms and cognitive deficit associated with…”
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Dissociation and association of the HIV-1 protease dimer subunits: Equilibria and rates by Darke, Paul L, Hall, Dawn L, Jordan, Susan P, Zugay, Joan A, Shafer, Jules A, Kuo, Lawrence C

“…The kinetics and equilibrium properties were investigated for the interconversion between the active dimer of human immunodeficiency virus 1 (HIV-1) protease…”
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Crystal structure of the Apo, unactivated insulin-like growth factor-1 receptor kinase. Implication for inhibitor specificity by Munshi, Sanjeev, Kornienko, Maria, Hall, Dawn L, Reid, John C, Waxman, Lloyd, Stirdivant, Steven M, Darke, Paul L, Kuo, Lawrence C

“…The x-ray structure of the unactivated kinase domain of insulin-like growth factor-1 receptor (IGFRK-0P) is reported here at 2.7 A resolution. IGFRK-0P is…”
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Biochemical and Structural Characterization of a Novel Class of Inhibitors of the Type 1 Insulin-like Growth Factor and Insulin Receptor Kinases by Bell, Ian M, Stirdivant, Steven M, Ahern, Janet, Culberson, J. Christopher, Darke, Paul L, Dinsmore, Christopher J, Drakas, Robert A, Gallicchio, Steven N, Graham, Samuel L, Heimbrook, David C, Hall, Dawn L, Hua, Jin, Kett, Nathan R, Kim, Annette S, Kornienko, Maria, Kuo, Lawrence C, Munshi, Sanjeev K, Quigley, Amy G, Reid, John C, Trotter, B. Wesley, Waxman, Lloyd H, Williams, Theresa M, Zartman, C. Blair

“…The type 1 insulin-like growth factor receptor (IGF-1R) is often overexpressed on tumor cells and is believed to play an important role in…”
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Expression, purification and crystallization of human prolylcarboxypeptidase by Abeywickrema, Pravien D., Patel, Sangita B., Byrne, Noel J., Diehl, Ronald E., Hall, Dawn L., Ford, Rachael E., Rickert, Keith W., Reid, John C., Shipman, Jennifer M., Geissler, Wayne M., Pryor, Kelly D., SinhaRoy, Ranabir, Soisson, Stephen M., Lumb, Kevin J., Sharma, Sujata

“…Prolylcarboxypeptidase (PrCP) is a lysosomal serine carboxypeptidase that cleaves a variety of C‐terminal amino acids adjacent to proline and has been…”
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Active Human Cytomegalovirus Protease Is a Dimer (∗) by Darke, Paul L., Cole, James L., Waxman, Lloyd, Hall, Dawn L., Sardana, Mohinder K., Kuo, Lawrence C.

“…The quaternary state of the human cytomegalovirus (hCMV) protease has been analyzed in relation to its catalysis of peptide hydrolysis. Based on results…”
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Activation of the Herpes Simplex Virus Type 1 Protease by Hall, D L, Darke, P L

“…The catalytic efficiency of the mature HSV-1 protease has been examined as a function of solvent composition. With the peptide substrate HTYLQASEKFKMWG-amide,…”
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Protein expression plasmids produced rapidly: streamlining cloning protocols and robotic handling by Kornienko, Maria, Montalvo, Allison, Carpenter, Brian E, Lenard, Michael, Abeywickrema, Pravien, Hall, Dawn L, Darke, Paul L, Kuo, Lawrence C

“…As many processes in the preclinical drug discovery process become highly parallel, the need to also produce a large number of different proteins in parallel…”
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Crystal Structure of the Apo, Unactivated Insulin-like Growth Factor-1 Receptor Kinase by Munshi, Sanjeev, Kornienko, Maria, Hall, Dawn L., Reid, John C., Waxman, Lloyd, Stirdivant, Steven M., Darke, Paul L., Kuo, Lawrence C.

“…The x-ray structure of the unactivated kinase domain of insulin-like growth factor-1 receptor (IGFRK-0P) is reported here at 2.7 Å resolution. IGFRK-0P is…”
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