Search Results - "Hall, D. Greg"

Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor by May, Patrick C, Dean, Robert A, Lowe, Stephen L, Martenyi, Ferenc, Sheehan, Scott M, Boggs, Leonard N, Monk, Scott A, Mathes, Brian M, Mergott, Dustin J, Watson, Brian M, Stout, Stephanie L, Timm, David E, Smith Labell, Elizabeth, Gonzales, Celedon R, Nakano, Masako, Jhee, Stanford S, Yen, Mark, Ereshefsky, Larry, Lindstrom, Terry D, Calligaro, David O, Cocke, Patrick J, Greg Hall, D, Friedrich, Stuart, Citron, Martin, Audia, James E

“…According to the amyloid cascade hypothesis, cerebral deposition of amyloid-β peptide (Aβ) is critical for Alzheimer's disease (AD) pathogenesis. Aβ generation…”
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Fundamentals of Neurobiology by Greg Hall, D.

“…Session 1 of the 2010 STP/IFSTP Joint Symposium on Toxicologic Neuropathology, titled “Fundamentals of Neurobiology,” was organized to provide a foundation for…”
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Temporal Profile of Clinical Signs and Histopathologic Changes in an F-344 Rat Model of Kainic Acid–induced Mesial Temporal Lobe Epilepsy by Sharma, Alok K., Jordan, William H., Reams, Rachel Y., Hall, D. Greg, Snyder, Paul W.

“…Since there is limited information in the literature, the purpose of this study was to investigate clinical signs, morphology, and temporal progression of…”
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A Comparison of Mortality and Cardiac Biomarker Response between Three Outbred Stocks of Sprague Dawley Rats Treated with Isoproterenol by Schultze, A. Eric, Main, Bradley W., Hall, D. Greg, Hoffman, Wherly P., Lee, H.-Y. Cindy, Ackermann, Bradley L., Pritt, Michael L., Smith, Holly W.

“…The authors compared the mortality and cardiac biomarker responses in three outbred stocks of Sprague Dawley rats (CD/IGS, Sasco, Harlan) treated with…”
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Dose‐dependent acute liver injury with hypersensitivity features in humans due to a novel microsomal prostaglandin E synthase 1 inhibitor by Jin, Yan, Regev, Arie, Kam, Jeanelle, Phipps, Krista, Smith, Claire, Henck, Judith, Campanale, Kristina, Hu, Leijun, Hall, D. Greg, Yang, Xiao Yan, Nakano, Masako, McNearney, Terry Ann, Uetrecht, Jack, Landschulz, William

“…Aims LY3031207, a novel microsomal prostaglandin E synthase 1 inhibitor, was evaluated in a multiple ascending dose study after nonclinical toxicology studies…”
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Caprine herpesvirus-2-associated malignant catarrhal fever in white-tailed deer (Odocoileus virginianus) by Li, H, Wunschmann, A, Keller, J, Hall, DG, Crawford, TB

“…Animal Diseases Research Unit, United States Department of Agriculture-Agriculture Research Service, Pullman, WA 99164, USA. A subacute disease presenting…”
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Initial biological qualification of SBDP-145 as a biomarker of compound-induced neurodegeneration in the rat by Pritt, Michael L, Hall, D Greg, Jordan, William H, Ballard, Darryl W, Wang, Kevin K W, Müller, Uwe R, Watson, David E

“…Detection of compound-related neurodegeneration is currently limited to brain histopathology in veterinary species and functional measurements such as…”
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Preparation and Analysis of the Central Nervous System by Jordan, William H., Young, Jamie K., Hyten, Monty J., Hall, D. Greg

“…For many pathologists, neuropathology is intimidating. Practical approaches for nervous tissue histologic evaluations to meet both routine and advanced study…”
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PARATUBERCULOSIS IN KEY DEER (ODOCOILEUS VIRGINIANUS CLAVIUM) by Quist, Charlotte F., Nettles, Victor F., Manning, Elizabeth J. B., Hall, D. Greg, Gaydos, Joseph K., Wilmers, Tom J., Lopez, Roel R.

“…Paratuberculosis was diagnosed in an endangered Key deer (Odocoileus virginianus clavium) in November 1996. Between 10 April 1997 and 28 September 2000, the…”
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Abnormal Cardiac Structure and Function in Mice Expressing Nonphosphorylatable Cardiac Regulatory Myosin Light Chain 2 by Sanbe, Atsushi, Fewell, Jason G., Gulick, James, Osinska, Hanna, Lorenz, John, Hall, D. Greg, Murray, Lisa A., Kimball, Thomas R., Witt, Sandra A., Robbins, Jeffrey

“…A role for myosin phosphorylation in modulating normal cardiac function has long been suspected, and we hypothesized that changing the phosphorylation status…”
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Proinflammatory consequences of transgenic Fas ligand expression in the heart by Nelson, David P., Setser, Elizabeth, Hall, D. Greg, Schwartz, Steven M., Hewitt, Timothy, Klevitsky, Raisa, Osinska, Hanna, Bellgrau, Don, Duke, Richard C., Robbins, Jeffrey

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Early onset heart failure in transgenic mice with dilated cardiomyopathy by HALL, D. G, MORLEY, G. E, VAIDYA, D, ARD, M, KIMBALL, T. R, WITT, S. A, COLBERT, M. C

“…In children, dilated cardiomyopathy is due to a variety of etiologies and usually carries a grave prognosis. The purpose of the present study was to carefully…”
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Transgenic over-expression of a motor protein at high levels results in severe cardiac pathology by JAMES, J, OSINSKA, H, HEWETT, T. E, KIMBALL, T, KLEVITSKY, R, WITT, S, HALL, D. G, GULICK, J, ROBBINS, J

“…Transgenesis has become a useful tool in effecting a complete or partial remodeling of the cardiac contractile apparatus. Although gene dosage effects were…”
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A familial degenerative neuromuscular disease of Gelbvieh cattle by Moisan, PG, Steffen, DJ, Sanderson, MW, Nietfeld, JC, Finley, MR, Grotelueschen, DM, Andrews, GA, Johnson, G, Williamson, L, Rushton, SD, Hall, DG, Harmon, BG

“…Rollins Animal Disease Diagnostic Laboratory, North Carolina Department of Agriculture, Raleigh, USA. A degenerative skeletal muscle disease with vascular,…”
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Robust Central Reduction of Amyloid-  in Humans with an Orally Available, Non-Peptidic  -Secretase Inhibitor by May, P. C., Dean, R. A., Lowe, S. L., Martenyi, F., Sheehan, S. M., Boggs, L. N., Monk, S. A., Mathes, B. M., Mergott, D. J., Watson, B. M., Stout, S. L., Timm, D. E., Smith LaBell, E., Gonzales, C. R., Nakano, M., Jhee, S. S., Yen, M., Ereshefsky, L., Lindstrom, T. D., Calligaro, D. O., Cocke, P. J., Greg Hall, D., Friedrich, S., Citron, M., Audia, J. E.

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Proinflammatory consequences of transgenic fas ligand expression in the heart by Nelson, D P, Setser, E, Hall, D G, Schwartz, S M, Hewitt, T, Klevitsky, R, Osinska, H, Bellgrau, D, Duke, R C, Robbins, J

“…Expression of Fas ligand (FasL) renders certain tissues immune privileged, but its expression in other tissues can result in severe neutrophil infiltration and…”
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Cardiac compartment-specific overexpression of a modified retinoic acid receptor produces dilated cardiomyopathy and congestive heart failure in transgenic mice by Colbert, M C, Hall, D G, Kimball, T R, Witt, S A, Lorenz, J N, Kirby, M L, Hewett, T E, Klevitsky, R, Robbins, J

“…Retinoids play a critical role in cardiac morphogenesis. To examine the effects of excessive retinoid signaling on myocardial development, transgenic mice that…”
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Effect of the bisphosphonate risedronate on bone metastases in a rat mammary adenocarcinoma model system by Hall, D. Greg, Stoica, George

“…Risedronate (NE‐58095) is a third‐generation bisphosphonate with very potent antiresorptive activity but few toxic effects. The purpose of this work was to…”
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Triage sepsis alert and sepsis protocol lower times to fluids and antibiotics in the ED by Hayden, Geoffrey E., MD, Tuuri, Rachel E., MD, Scott, Rachel, MD, Losek, Joseph D., MD, Blackshaw, Aaron M, Schoenling, Andrew J, Nietert, Paul J., PhD, Hall, Greg A., MD

“…Abstract Background Early identification of sepsis in the emergency department (ED), followed by adequate fluid hydration and appropriate antibiotics, improves…”
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M-Mode in the Emergency Department: Is It Really Necessary? by Blanco, Pablo, MD, Socransky, Steve, MD, FRCPC, DABEM, CEUS, Hall, Greg, MD, CCFP(EM), FCFP, CEUS

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