Search Results - "Hall, Brett M"

The role of Dickkopf-1 in bone development, homeostasis, and disease by Pinzone, Joseph J., Hall, Brett M., Thudi, Nanda K., Vonau, Martin, Qiang, Ya-Wei, Rosol, Thomas J., Shaughnessy, John D.

“…Wnt/β-catenin signaling is central to bone development and homeostasis in adulthood and its deregulation is associated with bone pathologies. Dickkopf-1…”
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Adult stem cells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of proliferation, and differentiation potential by Peister, Alexandra, Mellad, Jason A., Larson, Benjamin L., Hall, Brett M., Gibson, Laura F., Prockop, Darwin J.

“…For reasons that are not apparent, it has been difficult to isolate and expand the adult stem cells referred to as mesenchymal stem cells or marrow stromal…”
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Fibroblasts isolated from common sites of breast cancer metastasis enhance cancer cell growth rates and invasiveness in an interleukin-6-dependent manner by Studebaker, Adam W, Storci, Gianluca, Werbeck, Jillian L, Sansone, Pasquale, Sasser, A Kate, Tavolari, Simona, Huang, Tim, Chan, Michael W Y, Marini, Frank C, Rosol, Thomas J, Bonafé, Massimiliano, Hall, Brett M

“…Common sites of breast cancer metastasis include the lung, liver, and bone, and of these secondary metastatic sites, estrogen receptor alpha (ERalpha)-positive…”
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Differences in Hospital Billing for Total Joint Arthroplasty Based on Hospital Profit Status by Hall, Brett M., M.D, Odum, Susan M., PhD, Fehring, Thomas K., M.D, Stryker, Louis S., M.D

“…Abstract Background Regional variations in hospital billing for total joint arthroplasty (TJA) have been reported. It is not clear whether differences exist in…”
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Human bone marrow stromal cells enhance breast cancer cell growth rates in a cell line-dependent manner when evaluated in 3D tumor environments by Sasser, A. Kate, Mundy, Bethany L, Smith, Kristen M, Studebaker, Adam W, Axel, Amy E, Haidet, Amanda M, Fernandez, Soledad A, Hall, Brett M

“…Abstract Our understanding of the impact that fibroblasts have on cancer cell behavior in vivo has been limited by the complexities of in vivo tumor…”
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STAT3 can be activated through paracrine signaling in breast epithelial cells by Lieblein, Jacqueline C, Ball, Sarah, Hutzen, Brian, Sasser, A Kate, Lin, Huey-Jen, Huang, Tim Hm, Hall, Brett M, Lin, Jiayuh

“…Many cancers, including breast cancer, have been identified with increased levels of phosphorylated or the active form of Signal Transducers and Activators of…”
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Interleukin‐6 is a potent growth factor for ER‐α‐positive human breast cancer by Sasser, A. Kate, Sullivan, Nicholas J., Studebaker, Adam W., Hendey, Lindsay F., Axel, Amy E., Hall, Brett M.

“…ABSTRACT Bone is the primary anatomical site of breast cancer metastasis, and bone metastasis is associated with increased morbidity and mortality…”
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3-Dimensional Patient-Derived Lung Cancer Assays Reveal Resistance to Standards-of-Care Promoted by Stromal Cells but Sensitivity to Histone Deacetylase Inhibitors by Onion, David, Argent, Richard H, Reece-Smith, Alexander M, Craze, Madeleine L, Pineda, Robert G, Clarke, Philip A, Ratan, Hari L, Parsons, Simon L, Lobo, Dileep N, Duffy, John P, Atherton, John C, McKenzie, Andrew J, Kumari, Rajendra, King, Peter, Hall, Brett M, Grabowska, Anna M

“…There is a growing recognition that current preclinical models do not reflect the tumor microenvironment in cellular, biological, and biophysical content and…”
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Interleukin-6 is a potential therapeutic target in interleukin-6 dependent, estrogen receptor-α-positive breast cancer by Casneuf, Tineke, Axel, Amy E, King, Peter, Alvarez, John D, Werbeck, Jillian L, Verhulst, Tinne, Verstraeten, Karin, Hall, Brett M, Sasser, A Kate

“…Interleukin-6 (IL-6) is an important growth factor for estrogen receptor-α (ERα)-positive breast cancer, and elevated serum IL-6 is associated with poor…”
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Stromal cells regulate survival of B-lineage leukemic cells during chemotherapy by Mudry, Ryan E., Fortney, James E., York, Teresa, Hall, Brett M., Gibson, Laura F.

“…Approximately 20% of B-lineage acute lymphoblastic leukemias are not cured by traditional chemotherapy. The possibility was examined that residual leukemic…”
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Regulation of Lymphoid and Myeloid Leukemic Cell Survival: Role of Stromal Cell Adhesion Molecules by HALL, BRETT M, GIBSON, LAURA F

“…Several laboratories have documented the necessity for direct contact of lymphoid and myeloid leukemic cells with bone marrow stromal cells for optimal…”
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Stromal cells expressing elevated VCAM-1 enhance survival of B lineage tumor cells by Hall, Brett M., Fortney, James E., Taylor, Lela, Wood, Hillary, Wang, Lin, Adams, Scott, Davis, Suzanne, Gibson, Laura F.

“…In the current study we generated murine bone marrow stromal cells that constitutively express human VCAM-1. These stromal cell lines allow investigation of…”
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Abstract P254: Transcriptional effects in C26 tumor highlight mechanistic aspects of a novel dual MEK inhibitor, IMM-1-104 by Kolitz, Sarah E., Fowler, Kevin D., King, Peter J., Zeskind, Benjamin J., Hall, Brett M.

“…We developed a novel dual MEK inhibitor, IMM-1-104, that showed 94% tumor growth inhibition (TGI) in the syngeneic C26 mouse model through 10 days at 150 mg/kg…”
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NF-κB–YY1–miR-29 Regulatory Circuitry in Skeletal Myogenesis and Rhabdomyosarcoma by Wang, Huating, Garzon, Ramiro, Sun, Hao, Ladner, Katherine J., Singh, Ravi, Dahlman, Jason, Cheng, Alfred, Hall, Brett M., Qualman, Stephen J., Chandler, Dawn S., Croce, Carlo M., Guttridge, Denis C.

“…Studies support the importance of microRNAs in physiological and pathological processes. Here we describe the regulation and function of miR-29 in myogenesis…”
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Abstract P240: Benchmarking the novel dual-MEK inhibitor, IMM-1-104, head-to-head and in combination with sotorasib (AMG-510) in the MIA PaCa-2 (KRAS-G12C) pancreatic cancer xenograft model by King, Peter J., Axel, Amy E., Fowler, Kevin D., Kolitz, Sarah E., Barrett, Scott, Zeskind, Benjamin J., Hall, Brett M.

“…Background: Approximately 9 out of 10 patients diagnosed with pancreatic cancer have tumors driven by a single activating mutation in KRAS. These tumors remain…”
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Abstract P252: IMM-1-104: a novel, oral, selective dual-MEK inhibitor that displays broad antitumor activity and high tolerability across RAS and RAF mutant tumors in vivo by King, Peter J., Fowler, Kevin D., Kolitz, Sarah E., Barrett, Scott, Zeskind, Benjamin J., Hall, Brett M.

“…Background: Inappropriate activation of the MAPK pathway, often stemming from mutations in RAS or RAF, represents one of the most common oncogenic events in…”
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Abstract 5767: Ex vivo three-dimensional tumor growth assay: 3DX-TGA by Nair, Praveen, Nair, Dileep, Hinata, Kaede, Mirsaidi, Cyrus, Wu, Junjie, Hu, Yong, Hall, Brett M.

“…With a 7% likelihood of regulatory approval, oncology drug registration failure rates lead all therapeutic areas. Further complicating the drug development…”
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Chemotherapy Induces Bcl-2 Cleavage in Lymphoid Leukemic Cell Lines by Fortney, James E., Hall, Brett M., Bartrug, Lindsay, Gibson, Laura F.

“…Bcl-2 is the major anti-apoptotic protein evaluated in studies aimed at understanding programmed cell death. Recent work suggests that the biological activity…”
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Abstract 4265: Humanized 3D tumor models that are mutationally aligned with AACR GENIE patients predict IMM-1-104 activity in RAS-addicted tumors by Nair, Praveen, Kolitz, Sarah, Funt, Jason, King, Peter J., Fowler, Kevin D., Travesa, Anna, Rose, Ian, Brothers, John, Axel, Amy, Barrett, Scott, Zeskind, Benjamin J., Hall, Brett M.

“…Introduction: IMM-1-104, with pan-RAS activity through deep cyclic inhibition MEK, was evaluated in humanized 3D preclinical tumor models displaying diverse…”
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Abstract 4195: Activity of IMM-1-104 alone or in combination with chemotherapy in RAS-altered pancreatic cancer models by King, Peter, Funt, Jason, Kolitz, Sarah, Nair, Praveen, de Jong, Jan, Yamamura, Amy, Johnson, Mai, Zhang, Jenny, Fowler, Kevin, Travesa, Anna, Axel, Amy, Walker, Chris, Zeskind, Benjamin J., Hall, Brett M.

“…Introduction: Addiction to the MAPK pathway drives a large proportion of cancers, and pancreatic tumors almost universally display RAS mutations. IMM-1-104, a…”
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