Search Results - "Hall, Amelia W"

Transcriptional and Cellular Diversity of the Human Heart by Tucker, Nathan R., Chaffin, Mark, Fleming, Stephen J., Hall, Amelia W., Parsons, Victoria A., Bedi, Kenneth C., Akkad, Amer-Denis, Herndon, Caroline N., Arduini, Alessandro, Papangeli, Irinna, Roselli, Carolina, Aguet, François, Choi, Seung Hoan, Ardlie, Kristin G., Babadi, Mehrtash, Margulies, Kenneth B., Stegmann, Christian M., Ellinor, Patrick T.

“…BACKGROUND:The human heart requires a complex ensemble of specialized cell types to perform its essential function. A greater knowledge of the intricate…”
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Conserved properties of individual Ca2+-binding sites in calmodulin by Halling, D. Brent, Liebeskind, Benjamin J., Hall, Amelia W., Aldrich, Richard W.

“…Calmodulin (CaM) is a Ca2+-sensing protein that is highly conserved and ubiquitous in eukaryotes. In humans it is a locus of life-threatening cardiomyopathies…”
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Clinical and genetic associations of deep learning-derived cardiac magnetic resonance-based left ventricular mass by Khurshid, Shaan, Lazarte, Julieta, Pirruccello, James P., Weng, Lu-Chen, Choi, Seung Hoan, Hall, Amelia W., Wang, Xin, Friedman, Samuel F., Nauffal, Victor, Biddinger, Kiran J., Aragam, Krishna G., Batra, Puneet, Ho, Jennifer E., Philippakis, Anthony A., Ellinor, Patrick T., Lubitz, Steven A.

“…Left ventricular mass is a risk marker for cardiovascular events, and may indicate an underlying cardiomyopathy. Cardiac magnetic resonance is the…”
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Single-nucleus RNA sequencing in ischemic cardiomyopathy reveals common transcriptional profile underlying end-stage heart failure by Simonson, Bridget, Chaffin, Mark, Hill, Matthew C., Atwa, Ondine, Guedira, Yasmine, Bhasin, Harshit, Hall, Amelia W., Hayat, Sikander, Baumgart, Simon, Bedi, Kenneth C., Margulies, Kenneth B., Klattenhoff, Carla A., Ellinor, Patrick T.

“…Ischemic cardiomyopathy (ICM) is the leading cause of heart failure worldwide, yet the cellular and molecular signature of this disease is largely unclear…”
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Increased atrial effectiveness of flecainide conferred by altered biophysical properties of sodium channels by O' Brien, Sian, Holmes, Andrew P., Johnson, Daniel M., Kabir, S. Nashitha, O' Shea, Christopher, O' Reilly, Molly, Avezzu, Adelisa, Reyat, Jasmeet S., Hall, Amelia W., Apicella, Clara, Ellinor, Patrick T., Niederer, Steven, Tucker, Nathan R., Fabritz, Larissa, Kirchhof, Paulus, Pavlovic, Davor

“…Atrial fibrillation (AF) affects over 1% of the population and is a leading cause of stroke and heart failure in the elderly. A feared side effect of sodium…”
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Monogenic and Polygenic Contributions to Atrial Fibrillation Risk: Results From a National Biobank by Choi, Seung Hoan, Jurgens, Sean J., Weng, Lu-Chen, Pirruccello, James P., Roselli, Carolina, Chaffin, Mark, Lee, Christina J.-Y., Hall, Amelia W., Khera, Amit V., Lunetta, Kathryn L., Lubitz, Steven A., Ellinor, Patrick T.

“…Genome-wide association studies have identified over 100 genetic loci for atrial fibrillation (AF); recent work described an association between…”
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Deep learning enables genetic analysis of the human thoracic aorta by Pirruccello, James P., Chaffin, Mark D., Chou, Elizabeth L., Fleming, Stephen J., Lin, Honghuang, Nekoui, Mahan, Khurshid, Shaan, Friedman, Samuel F., Bick, Alexander G., Arduini, Alessandro, Weng, Lu-Chen, Choi, Seung Hoan, Akkad, Amer-Denis, Batra, Puneet, Tucker, Nathan R., Hall, Amelia W., Roselli, Carolina, Benjamin, Emelia J., Vellarikkal, Shamsudheen K., Gupta, Rajat M., Stegmann, Christian M., Juric, Dejan, Stone, James R., Vasan, Ramachandran S., Ho, Jennifer E., Hoffmann, Udo, Lubitz, Steven A., Philippakis, Anthony A., Lindsay, Mark E., Ellinor, Patrick T.

“…Enlargement or aneurysm of the aorta predisposes to dissection, an important cause of sudden death. We trained a deep learning model to evaluate the dimensions…”
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Epigenetic and Transcriptional Networks Underlying Atrial Fibrillation by van Ouwerkerk, Antoinette F., Hall, Amelia W., Kadow, Zachary A., Lazarevic, Sonja, Reyat, Jasmeet S., Tucker, Nathan R., Nadadur, Rangarajan D., Bosada, Fernanda M., Bianchi, Valerio, Ellinor, Patrick T., Fabritz, Larissa, Martin, James F., de Laat, Wouter, Kirchhof, Paulus, Moskowitz, Ivan P., Christoffels, Vincent M.

“…Genome-wide association studies have uncovered over a 100 genetic loci associated with atrial fibrillation (AF), the most common arrhythmia. Many of the top…”
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Long-range Pitx2c enhancer–promoter interactions prevent predisposition to atrial fibrillation by Zhang, Min, Hill, Matthew C., Kadow, Zachary A., Suh, Ji Ho, Tucker, Nathan R., Hall, Amelia W., Tran, Tien T., Swinton, Paul S., Leach, John P., Margulies, Kenneth B., Ellinor, Patrick T., Li, Na, Martin, James F.

“…Genome-wide association studies found that increased risk for atrial fibrillation (AF), the most common human heart arrhythmia, is associated with noncoding…”
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Monogenic and Polygenic Contributions to QTc Prolongation in the Population by Nauffal, Victor, Morrill, Valerie N., Jurgens, Sean J., Choi, Seung Hoan, Hall, Amelia W., Weng, Lu-Chen, Halford, Jennifer L., Austin-Tse, Christina, Haggerty, Christopher M., Harris, Stephanie L., Wong, Eugene K., Alonso, Alvaro, Arking, Dan E., Benjamin, Emelia J., Boerwinkle, Eric, Min, Yuan-I, Correa, Adolfo, Fornwalt, Brandon K., Heckbert, Susan R., Kooperberg, Charles, Lin, Henry J., J.F. Loos, Ruth, Rice, Kenneth M., Gupta, Namrata, Blackwell, Thomas W., Mitchell, Braxton D., Morrison, Alanna C., Psaty, Bruce M., Post, Wendy S., Redline, Susan, Rehm, Heidi L., Rich, Stephen S., Rotter, Jerome I., Soliman, Elsayed Z., Sotoodehnia, Nona, Lunetta, Kathryn L., Ellinor, Patrick T., Lubitz, Steven A.

“…Rare sequence variation in genes underlying cardiac repolarization and common polygenic variation influence QT interval duration. However, current clinical…”
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Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes by Halford, Jennifer L., Morrill, Valerie N., Choi, Seung Hoan, Jurgens, Sean J., Melloni, Giorgio, Marston, Nicholas A., Weng, Lu-Chen, Nauffal, Victor, Hall, Amelia W., Gunn, Sophia, Austin-Tse, Christina A., Pirruccello, James P., Khurshid, Shaan, Rehm, Heidi L., Benjamin, Emelia J., Boerwinkle, Eric, Brody, Jennifer A., Correa, Adolfo, Fornwalt, Brandon K., Gupta, Namrata, Haggerty, Christopher M., Harris, Stephanie, Heckbert, Susan R., Hong, Charles C., Kooperberg, Charles, Lin, Henry J., Loos, Ruth J. F., Mitchell, Braxton D., Morrison, Alanna C., Post, Wendy, Psaty, Bruce M., Redline, Susan, Rice, Kenneth M., Rich, Stephen S., Rotter, Jerome I., Schnatz, Peter F., Soliman, Elsayed Z., Sotoodehnia, Nona, Wong, Eugene K., Sabatine, Marc S., Ruff, Christian T., Lunetta, Kathryn L., Ellinor, Patrick T., Lubitz, Steven A.

“…Accurate and efficient classification of variant pathogenicity is critical for research and clinical care. Using data from three large studies, we demonstrate…”
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Publisher Correction: Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes by Halford, Jennifer L., Morrill, Valerie N., Choi, Seung Hoan, Jurgens, Sean J., Melloni, Giorgio, Marston, Nicholas A., Weng, Lu-Chen, Nauffal, Victor, Hall, Amelia W., Gunn, Sophia, Austin-Tse, Christina A., Pirruccello, James P., Khurshid, Shaan, Rehm, Heidi L., Benjamin, Emelia J., Boerwinkle, Eric, Brody, Jennifer A., Correa, Adolfo, Fornwalt, Brandon K., Gupta, Namrata, Haggerty, Christopher M., Harris, Stephanie, Heckbert, Susan R., Hong, Charles C., Kooperberg, Charles, Lin, Henry J., Loos, Ruth J. F., Mitchell, Braxton D., Morrison, Alanna C., Post, Wendy, Psaty, Bruce M., Redline, Susan, Rice, Kenneth M., Rich, Stephen S., Rotter, Jerome I., Schnatz, Peter F., Soliman, Elsayed Z., Sotoodehnia, Nona, Wong, Eugene K., Sabatine, Marc S., Ruff, Christian T., Lunetta, Kathryn L., Ellinor, Patrick T., Lubitz, Steven A.

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EF hands at the N-lobe of calmodulin are required for both SK channel gating and stable SK-calmodulin interaction by Li, Weiyan, Halling, David B, Hall, Amelia W, Aldrich, Richard W

“…Small conductance calcium-activated potassium (SK) channels respond to intracellular Ca(2+) via constitutively associated calmodulin (CaM). Previous studies…”
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Novel association of polymorphic genetic variants with predictors of outcome of catheter ablation in atrial fibrillation: new directions from a prospective study (DECAF) by Mohanty, Sanghamitra, Hall, Amelia W., Mohanty, Prasant, Prakash, Sameer, Trivedi, Chintan, Di Biase, Luigi, Santangeli, Pasquale, Bai, Rong, Burkhardt, J. David, Gallinghouse, G. Joseph, Horton, Rodney, Sanchez, Javier E., Hranitzky, Patrick M., Al-Ahmad, Amin, Iyer, Vishwanath R., Natale, Andrea

“…Purpose Non-pulmonary vein (non-PV) triggers and left atrial (LA) scars perpetuate atrial fibrillation (AF) and limit the success rate of catheter ablation. In…”
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NOVEL ASSOCIATION OF POLYMORPHIC GENETIC VARIANTS WITH PREDICTORS OF OUTCOME OF CATHETER ABLATION IN ATRIAL FIBRILLATION: NEW DIRECTIONS FROM A PROSPECTIVE STUDY (DECAF) by Mohanty, Sanghamitra, Hall, Amelia W, Mohanty, Prasant, Prakash, Sameer, Trivedi, Chintan, Biase, Luigi Di, Santangeli, Pasquale, Gianni, Carola, Bai, Rong, Burkhardt, John, Gallinghouse, Joe, Horton, Rodney, Sanchez, Javier, Hranitzky, Patrick, Al-Ahmad, Amin, Iyer, Viswanath R, Natale, Andrea

“…Multivariate logistic regression analysis (adjusted covariates: age, gender, LA size, hypertension and diabetes) was used for assessing predictive role of…”
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Analysis of rare genetic variation underlying cardiometabolic diseases and traits among 200,000 individuals in the UK Biobank by Jurgens, Sean J., Choi, Seung Hoan, Morrill, Valerie N., Chaffin, Mark, Pirruccello, James P., Halford, Jennifer L., Weng, Lu-Chen, Nauffal, Victor, Roselli, Carolina, Hall, Amelia W., Oetjens, Matthew T., Lagerman, Braxton, vanMaanen, David P., Aragam, Krishna G., Lunetta, Kathryn L., Haggerty, Christopher M., Lubitz, Steven A., Ellinor, Patrick T.

“…Cardiometabolic diseases are the leading cause of death worldwide. Despite a known genetic component, our understanding of these diseases remains incomplete…”
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Deep learning enables genetic analysis of the human thoracic aorta by Pirruccello, James P, Chaffin, Mark D, Chou, Elizabeth L, Fleming, Stephen J, Lin, Honghuang, Nekoui, Mahan, Khurshid, Shaan, Friedman, Samuel F, Bick, Alexander G, Arduini, Alessandro, Weng, Lu-Chen, Choi, Seung Hoan, Akkad, Amer-Denis, Batra, Puneet, Tucker, Nathan R, Hall, Amelia W, Roselli, Carolina, Benjamin, Emelia J, Vellarikkal, Shamsudheen K, Gupta, Rajat M, Stegmann, Christian M, Juric, Dejan, Stone, James R, Vasan, Ramachandran S, Ho, Jennifer E, Hoffmann, Udo, Lubitz, Steven A, Philippakis, Anthony A, Lindsay, Mark E, Ellinor, Patrick T

“…Enlargement or aneurysm of the aorta predisposes to dissection, an important cause of sudden death. We trained a deep learning model to evaluate the dimensions…”
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Conserved properties of individual Ca^sup 2+^-binding sites in calmodulin by Halling, D Brent, Liebeskind, Benjamin J, Hall, Amelia W, Aldrich, Richard W

“…Calmodulin (CaM) is a Ca2+-sensing protein that is highly conserved and ubiquitous in eukaryotes. In humans it is a locus of life-threatening cardiomyopathies…”
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Conserved properties of individual Ca 2+ -binding sites in calmodulin by Halling, D. Brent, Liebeskind, Benjamin J., Hall, Amelia W., Aldrich, Richard W.

“…Significance Calmodulin is essential for sensing intracellular Ca 2+ in eukaryotic cells. Calmodulin modulates hundreds of effectors, and it has a highly…”
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Conserved properties of individual Ca super( 2+)-binding sites in calmodulin by Halling, D Brent, Liebeskind, Benjamin J, Hall, Amelia W, Aldrich, Richard W

“…Calmodulin (CaM) is a Ca2+-sensing protein that is highly conserved and ubiquitous in eukaryotes. In humans it is a locus of life-threatening cardiomyopathies…”
Get full text