Search Results - "Halim, Rosliana"

Synthesis of Thieno-Fused Heterocycles through Reiterative Iodocyclization by Aurelio, Luigi, Volpe, Rohan, Halim, Rosliana, Scammells, Peter J., Flynn, Bernard L.

“…Iodocyclization of ethynyl methyl sulfides gives 3‐iodo‐2‐thiomethyl heterocycles, setting up the synthesis of thieno‐fused systems through a subsequent…”
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Scaffold-Divergent Synthesis of Ring-Fused Indoles, Quinolines, and Quinolones via Iodonium-Induced Reaction Cascades by Halim, Rosliana, Aurelio, Luigi, Scammells, Peter J, Flynn, Bernard L

“…N-(2-Iodophenyl)­imines A are readily formed from Schiff’s base condensation of 2-iodoanilines with carbonyls and ketals. These imines provide useful…”
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Alternating Iodonium-Mediated Reaction Cascades Giving Indole- And Quinoline-Containing Polycycles by Halim, Rosliana, Scammells, Peter J, Flynn, Bernard L

“…A simple two-step convergent protocol gives direct access to synthetic intermediate A from ortho-iodoanilines. Intermediate A can be treated with NIS in CH2Cl2…”
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Synthetic studies towards the pectenotoxins: a review by Halim, Rosliana, Brimble, Margaret A

“…In this article we provide an overview of synthetic studies towards pectenotoxins (PTXs) that have been reported by several research groups. The difficulties…”
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Synthesis of the ABC Fragment of the Pectenotoxins by Halim, Rosliana, Brimble, Margaret A, Merten, Jörn

“…A highly stereocontrolled synthesis of the C1−C16 ABC spiroacetal-containing fragment 5 of PTX7 (4) has been achieved. Appendage of the C ring to the AB…”
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Synthetic studies toward shellfish toxins containing spiroacetal units by Brimble, Margaret A., Halim, Rosliana

“…The synthesis of the ABC spiroacetal-containing fragment of the marine biotoxins, the pectenotoxins (PTXs), is described. The synthetic strategy involves…”
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Addition of a chiral non-racemic silyloxypyrrole to an activated 1,4-benzoquinone by Halim, Rosliana, Brimble, Margaret A., D.Woodgate, Paul

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Prodrugs of imidazotriazine and pyrrolotriazine C-nucleosides can increase anti-HCV activity and enhance nucleotide triphosphate concentrations in vitro by Tyndall, Edward M., Draffan, Alistair G., Frey, Barbara, Pool, Brett, Halim, Rosliana, Jahangiri, Saba, Bond, Silas, Wirth, Veronika, Luttick, Angela, Tilmanis, Danielle, Thomas, Jesse, Porter, Kate, Tucker, Simon P.

“…[Display omitted] A number of prodrugs of HCV-active purine nucleoside analogues 2′-C-methyl 4-aza-9-deaza adenosine 1, 2′-C-methyl 4-aza-7,9-dideaza adenosine…”
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Derivatives of imidazotriazine and pyrrolotriazine C-nucleosides as potential new anti-HCV agents by Draffan, Alistair G., Frey, Barbara, Fraser, Benjamin H., Pool, Brett, Gannon, Carlie, Tyndall, Edward M., Cianci, Julia, Harding, Michael, Lilly, Michael, Hufton, Richard, Halim, Rosliana, Jahangiri, Saba, Bond, Silas, Jeynes, Tyrone P., Nguyen, Van T.T., Wirth, Veronika, Luttick, Angela, Tilmanis, Danielle, Pryor, Melinda, Porter, Kate, Morton, Craig J., Lin, Bo, Duan, Jianmin, Bethell, Richard C., Kukolj, George, Simoneau, Bruno, Tucker, Simon P.

“…[Display omitted] Previous investigations identified 2′-C-Me-branched ribo-C-nucleoside adenosine analogues, 1, which contains a…”
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Discovery and Synthesis of C‑Nucleosides as Potential New Anti-HCV Agents by Draffan, Alistair G, Frey, Barbara, Pool, Brett, Gannon, Carlie, Tyndall, Edward M, Lilly, Michael, Francom, Paula, Hufton, Richard, Halim, Rosliana, Jahangiri, Saba, Bond, Silas, Nguyen, Van T. T, Jeynes, Tyrone P, Wirth, Veronika, Luttick, Angela, Tilmanis, Danielle, Thomas, Jesse D, Pryor, Melinda, Porter, Kate, Morton, Craig J, Lin, Bo, Duan, Jianmin, Kukolj, George, Simoneau, Bruno, McKercher, Ginette, Lagacé, Lisette, Amad, Ma’an, Bethell, Richard C, Tucker, Simon P

“…Nucleoside analogues have long been recognized as prospects for the discovery of direct acting antivirals (DAAs) to treat hepatitis C virus because they have…”
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Synthesis of the ABC tricyclic fragment of the pectenotoxins via stereocontrolled cyclization of a gamma-hydroxyepoxide appended to the AB spiroacetal unit by Halim, Rosliana, Brimble, Margaret A, Merten, Jörn

“…The stereocontrolled synthesis of the C1-C16 ABC spiroacetal-containing tricyclic fragment of pectenotoxin-7 6 has been accomplished. The key AB spiroacetal…”
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Uncatalyzed addition of N-( tert-butoxycarbonyl)-2- tert-butyldimethylsilyloxypyrrole to activated quinones by Brimble, Margaret A., Halim, Rosliana, Petersson, Maria

“…The uncatalyzed addition of N-( tert-butoxycarbonyl)-2- tert-butyldimethylsilyloxypyrrole 3 to 1,4-quinones bearing an electron withdrawing group at C-2 is…”
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Synthesis of pyrrolo[3,2- b]benzofurans and pyrrolo[3,2- b]naphthofurans via addition of a silyloxypyrrole to activated quinones by Brimble, Margaret A, Burgess, Caryn, Halim, Rosliana, Petersson, Maria, Ray, Jayanta

“…The uncatalyzed reaction of N-( tert-butoxycarbonyl)-2- tert-butyldimethylsilyloxypyrrole 3 with 1,4-quinones bearing an electron withdrawing group at C-2 has…”
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