Search Results - "Halik, Paweł"

Overview of Dual-Acting Drug Methotrexate in Different Neurological Diseases, Autoimmune Pathologies and Cancers by Koźmiński, Przemysław, Halik, Paweł Krzysztof, Chesori, Raphael, Gniazdowska, Ewa

“…Methotrexate, a structural analogue of folic acid, is one of the most effective and extensively used drugs for treating many kinds of cancer or severe and…”
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Perspectives of Methotrexate-Based Radioagents for Application in Nuclear Medicine by Halik, Paweł Krzysztof, Koźmiński, Przemysław, Gniazdowska, Ewa

“…Methotrexate is a gold standard among disease modifying antirheumatic drugs and is also extensively used clinically in combination with oncological therapies…”
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The Significance of NK1 Receptor Ligands and Their Application in Targeted Radionuclide Tumour Therapy by Majkowska-Pilip, Agnieszka, Halik, Paweł Krzysztof, Gniazdowska, Ewa

“…To date, our understanding of the Substance P (SP) and neurokinin 1 receptor (NK1R) system shows intricate relations between human physiology and disease…”
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Common Shortcomings in Study on Radiopharmaceutical Design Research: A Case Study of 99mTc-Labelled Methotrexate by Koźmiński, Przemysław, Halik, Paweł Krzysztof, Chesori, Raphael, Gniazdowska, Ewa

“…The aim of the work carried out was to draw attention to shortcomings that often appear at the stage of designing new radiopharmaceuticals. Based on a case…”
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Synthesis, physicochemical and in vitro biological evaluation of 99mTc-cefepime radioconjugates, and development of DTPA-cefepime single vial kit formulation for labelling with technetium-99m by Koźmiński, Przemysław, Rzewuska, Magdalena, Piądłowska, Agata, Halik, Paweł, Gniazdowska, Ewa

“…In the present work the synthesis, physicochemical properties and biological evaluation of cefepime (CFM) labelled with technetium-99m were studied. Two…”
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The selective response of a templated polymer for the cationic drug pentamidine: implications from molecular simulations and experimental data by Sobiech, Monika, Luliński, Piotr, Halik, Paweł, Maciejewska, Dorota

“…In this paper, we present an analysis of the surface modifications responsible for the selectivity of a new imprinted sorbent produced for the isolation of…”
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In Vitro Biological Evaluation of Aprepitant Based 177Lu-Radioconjugates by Halik, Paweł K., Koźmiński, Przemysław, Matalińska, Joanna, Lipiński, Piotr F. J., Misicka, Aleksandra, Gniazdowska, Ewa

“…Currently, the search for promising NK1R-positive tumor-targeting radiopharmaceuticals based on the structure of small molecular antagonists of neurokinin-1…”
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In Vitro Biological Evaluation of Aprepitant Based 177 Lu-Radioconjugates by Halik, Paweł K, Koźmiński, Przemysław, Matalińska, Joanna, Lipiński, Piotr F J, Misicka, Aleksandra, Gniazdowska, Ewa

“…Currently, the search for promising NK1R-positive tumor-targeting radiopharmaceuticals based on the structure of small molecular antagonists of neurokinin-1…”
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Scandium-44 Radiolabeled Peptide and Peptidomimetic Conjugates Targeting Neuropilin-1 Co-Receptor as Potential Tools for Cancer Diagnosis and Anti-Angiogenic Therapy by Masłowska, Katarzyna, Redkiewicz, Patrycja, Halik, Paweł Krzysztof, Witkowska, Ewa, Tymecka, Dagmara, Walczak, Rafał, Choiński, Jarosław, Misicka, Aleksandra, Gniazdowska, Ewa

“…Pathological angiogenesis, resulting from an imbalance between anti- and pro-angiogenic factors, plays a pivotal role in tumor growth, development and…”
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Synthesis, Physicochemical and Biological Study of Gallium-68- and Lutetium-177-Labeled VEGF-A165/NRP-1 Complex Inhibitors Based on Peptide A7R and Branched Peptidomimetic by Masłowska, Katarzyna, Witkowska, Ewa, Tymecka, Dagmara, Halik, Paweł Krzysztof, Misicka, Aleksandra, Gniazdowska, Ewa

“…Neuropilin-1 (NRP-1) is a surface receptor found on many types of cancer cells. The overexpression of NRP-1 and its interaction with vascular endothelial…”
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Novel NK1R-Targeted 68Ga-/177Lu-Radioconjugates with Potential Application against Glioblastoma Multiforme: Preliminary Exploration of Structure–Activity Relationships by Matalińska, Joanna, Kosińska, Katarzyna, Halik, Paweł K., Koźmiński, Przemysław, Lipiński, Piotr F. J., Gniazdowska, Ewa, Misicka, Aleksandra

“…Locoregionally administered, NK1 receptor (NK1R) targeted radionuclide therapy is a promising strategy for the treatment of glioblastoma multiforme. So far,…”
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The Role of VEGF Receptors as Molecular Target in Nuclear Medicine for Cancer Diagnosis and Combination Therapy by Masłowska, Katarzyna, Halik, Paweł Krzysztof, Tymecka, Dagmara, Misicka, Aleksandra, Gniazdowska, Ewa

“…One approach to anticancer treatment is targeted anti-angiogenic therapy (AAT) based on prevention of blood vessel formation around the developing cancer…”
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Radiochemical Synthesis and Evaluation of Novel Radioconjugates of Neurokinin 1 Receptor Antagonist Aprepitant Dedicated for NK1R-Positive Tumors by Halik, Paweł K, Lipiński, Piotr F J, Matalińska, Joanna, Koźmiński, Przemysław, Misicka, Aleksandra, Gniazdowska, Ewa

“…Aprepitant, a lipophilic and small molecular representative of neurokinin 1 receptor antagonists, is known for its anti-proliferative activity on numerous…”
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New Imaging Modality of COVID-19 Pneumonia Developed on the Basis of Alzheimer’s Disease Research by Koźmiński, Przemysław, Niedziałek, Dorota, Wieczorek, Grzegorz, Halik, Paweł K., Czarnecka, Kamila, Rogut, Aleksandra, Cheda, Łukasz, Rogulski, Zbigniew, Szymański, Paweł, Gniazdowska, Ewa

“…Viral pneumonia caused by highly infectious SARS-CoV-2 poses a higher risk to older people and those who have underlying health conditions, including…”
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Bifunctional Opioid/Melanocortin Peptidomimetics for Use in Neuropathic Pain: Variation in the Type and Length of the Linker Connecting the Two Pharmacophores by Witkowska, Ewa, Godlewska, Magda, Osiejuk, Jowita, Gątarz, Sandra, Wileńska, Beata, Kosińska, Katarzyna, Starnowska-Sokół, Joanna, Piotrowska, Anna, Lipiński, Piotr F J, Matalińska, Joanna, Dyniewicz, Jolanta, Halik, Paweł K, Gniazdowska, Ewa, Przewlocka, Barbara, Misicka, Aleksandra

“…Based on the mechanism of neuropathic pain induction, a new type of bifunctional hybrid peptidomimetics was obtained for potential use in this type of pain…”
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Physicochemical and Biological Study of 99mTc and 68Ga Radiolabelled Ciprofloxacin and Evaluation of [99mTc]Tc-CIP as Potential Diagnostic Radiopharmaceutical for Diabetic Foot Syndrome Imaging by Koźmiński, Przemysław, Gawęda, Weronika, Rzewuska, Magdalena, Kopatys, Agata, Kujda, Szymon, Dudek, Marta K., Halik, Paweł Krzysztof, Królicki, Leszek, Gniazdowska, Ewa

“…This paper presents the application of ciprofloxacin as a biologically active molecule (vector) for delivering diagnostic radiopharmaceuticals to the sites of…”
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Synthesis, physicochemical and biological evaluation of tacrine derivative labeled with technetium-99m and gallium-68 as a prospective diagnostic tool for early diagnosis of Alzheimer’s disease by Gniazdowska, Ewa, Koźmiński, Przemysław, Halik, Paweł, Bajda, Marek, Czarnecka, Kamila, Mikiciuk-Olasik, Elżbieta, Masłowska, Katarzyna, Rogulski, Zbigniew, Cheda, Łukasz, Kilian, Krzysztof, Szymański, Paweł

“…[Display omitted] •New tacrine analogues were labeled with technetium-99m and gallium-68.•Novel radioconjugates showed high stability in biological…”
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Synthesis, Physicochemical and Biological Study of Gallium-68- and Lutetium-177-Labeled VEGF-A 165 /NRP-1 Complex Inhibitors Based on Peptide A7R and Branched Peptidomimetic by Masłowska, Katarzyna, Witkowska, Ewa, Tymecka, Dagmara, Halik, Paweł Krzysztof, Misicka, Aleksandra, Gniazdowska, Ewa

“…Neuropilin-1 (NRP-1) is a surface receptor found on many types of cancer cells. The overexpression of NRP-1 and its interaction with vascular endothelial…”
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Novel NK1R-Targeted 68 Ga-/ 177 Lu-Radioconjugates with Potential Application against Glioblastoma Multiforme: Preliminary Exploration of Structure-Activity Relationships by Matalińska, Joanna, Kosińska, Katarzyna, Halik, Paweł K, Koźmiński, Przemysław, Lipiński, Piotr F J, Gniazdowska, Ewa, Misicka, Aleksandra

“…Locoregionally administered, NK1 receptor (NK1R) targeted radionuclide therapy is a promising strategy for the treatment of glioblastoma multiforme. So far,…”
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Physicochemical and Biological Study of 99m Tc and 68 Ga Radiolabelled Ciprofloxacin and Evaluation of [ 99m Tc]Tc-CIP as Potential Diagnostic Radiopharmaceutical for Diabetic Foot Syndrome Imaging by Koźmiński, Przemysław, Gawęda, Weronika, Rzewuska, Magdalena, Kopatys, Agata, Kujda, Szymon, Dudek, Marta K, Halik, Paweł Krzysztof, Królicki, Leszek, Gniazdowska, Ewa

“…This paper presents the application of ciprofloxacin as a biologically active molecule (vector) for delivering diagnostic radiopharmaceuticals to the sites of…”
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