Search Results - "Halfon, Philippe"

HCV direct-acting antiviral agents: the best interferon-free combinations by Schinazi, Raymond, Halfon, Philippe, Marcellin, Patrick, Asselah, Tarik

“…For HCV infection, there have been major advancements during last several years with large numbers of ongoing trials with various direct‐acting antivirals…”
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Monocytes and Macrophages, Targets of Severe Acute Respiratory Syndrome Coronavirus 2: The Clue for Coronavirus Disease 2019 Immunoparalysis by Boumaza, Asma, Gay, Laetitia, Mezouar, Soraya, Bestion, Eloïne, Diallo, Aïssatou Bailo, Michel, Moise, Desnues, Benoit, Raoult, Didier, La Scola, Bernard, Halfon, Philippe, Vitte, Joana, Olive, Daniel, Mege, Jean-Louis

“…Abstract Background Coronavirus disease 2019 (COVID-19) clinical expression is pleiomorphic, severity is related to age and comorbidities such as diabetes and…”
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A Granulocytic Signature Identifies COVID-19 and Its Severity by Vitte, Joana, Diallo, Aïssatou Bailo, Boumaza, Asma, Lopez, Alexandre, Michel, Moïse, Allardet-Servent, Jérôme, Mezouar, Soraya, Sereme, Youssouf, Busnel, Jean-Marc, Miloud, Tewfik, Malergue, Fabrice, Morange, Pierre-Emmanuel, Halfon, Philippe, Olive, Daniel, Leone, Marc, Mege, Jean-Louis

“…Abstract Background An unbiased approach to SARS-CoV-2–induced immune dysregulation has not been undertaken so far. We aimed to identify previously unreported…”
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Proof of concept study on early forecasting of antimicrobial resistance in hospitalized patients using machine learning and simple bacterial ecology data by Urena, Raquel, Camiade, Sabine, Baalla, Yasser, Piarroux, Martine, Vouriot, Laurent, Halfon, Philippe, Gaudart, Jean, Dufour, Jean-Charles, Rebaudet, Stanislas

“…Antibiotic resistance in bacterial pathogens is a major threat to global health, exacerbated by the misuse of antibiotics. In hospital practice, results of…”
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Gut microbiota in systemic lupus erythematosus patients and lupus mouse model: a cross species comparative analysis for biomarker discovery by Toumi, Eya, Goutorbe, Benoit, Plauzolles, Anne, Bonnet, Marion, Mezouar, Soraya, Militello, Muriel, Mege, Jean-Louis, Chiche, Laurent, Halfon, Philippe

“…An increasing number of studies have provided strong evidence that gut microbiota interact with the immune system and stimulate various mechanisms involved in…”
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Prospective screening of liver fibrosis in a primary care cohort using systematic calculation of fib-4 in routine results by Halfon, Philippe, Ansaldi, Christelle, Penaranda, Guillaume, Chiche, Laurent, Dukan, Patrick, Stavris, Chloé, Plauzolles, Anne, Retornaz, Frédérique, Bourliere, Marc

“…Background & aim Liver fibrosis screening in primary care population is a major public health issue. The FIB-4 index is a simple non-invasive fibrosis test…”
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Cell and Animal Models for SARS-CoV-2 Research by Bestion, Eloïne, Halfon, Philippe, Mezouar, Soraya, Mège, Jean-Louis

“…During the last two years following the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, development of potent antiviral drugs and…”
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CMV drives clonal expansion of NKG2C+ NK cells expressing self‐specific KIRs in chronic hepatitis patients by Béziat, Vivien, Dalgard, Olav, Asselah, Tarik, Halfon, Philippe, Bedossa, Pierre, Boudifa, Ali, Hervier, Baptiste, Theodorou, Ioannis, Martinot, Michelle, Debré, Patrice, Björkström, Niklas K., Malmberg, Karl‐Johan, Marcellin, Patrick, Vieillard, Vincent

“…Natural killer (NK) cells are affected by infection with human cytomegalovirus (HCMV) manifested by increased expression of the HLA‐E binding activating…”
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CpG methylation controls reactivation of HIV from latency by Blazkova, Jana, Trejbalova, Katerina, Gondois-Rey, Françoise, Halfon, Philippe, Philibert, Patrick, Guiguen, Allan, Verdin, Eric, Olive, Daniel, Van Lint, Carine, Hejnar, Jiri, Hirsch, Ivan

“…DNA methylation of retroviral promoters and enhancers localized in the provirus 5' long terminal repeat (LTR) is considered to be a mechanism of…”
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Acceptability and efficacy of vaginal self-sampling for genital infection and bacterial vaginosis: A cross-sectional study by Camus, Claire, Penaranda, Guillaume, Khiri, Hacène, Camiade, Sabine, Molet, Lucie, Lebsir, Melissa, Plauzolles, Anne, Chiche, Laurent, Blanc, Bernard, Quarello, Edwin, Halfon, Philippe

“…Screening for genital infection (GI) such as bacterial vaginosis (BV) and yeast infection, for sexually transmitted infection (STI), and for asymptomatic…”
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Anti-spike protein to determine SARS-CoV-2 antibody levels: Is there a specific threshold conferring protection in immunocompromised patients? by Halfon, Philippe, Jordana, Sylvie, Blachier, Stéphane, Cartlamy, Philippe, Kbaier, Laurent, Psomas, Christina K, Philibert, Patrick, Antoniotti, Gilles, Allemand-Sourrieu, Julie, Rebaudet, Stanislas, Cavaille, Guilhem, Stavris, Chloé, Retornaz, Frédérique, Chiche, Laurent, Penaranda, Guillaume

“…Identifying a specific threshold level of SARS-CoV-2 antibodies that confers protection in immunocompromised patients has been very challenging. The aim was to…”
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Update on Autophagy Inhibitors in Cancer: Opening up to a Therapeutic Combination with Immune Checkpoint Inhibitors by Bestion, Eloïne, Raymond, Eric, Mezouar, Soraya, Halfon, Philippe

“…Autophagy is a highly conserved and natural degradation process that helps maintain cell homeostasis through the elimination of old, worn, and defective…”
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HCV resistance by Halfon, Philippe

“…Doc number: I18…”
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An optimized stepwise algorithm combining rapid antigen and RT-qPCR for screening of COVID-19 patients by Halfon, Philippe, Penaranda, Guillaume, Khiri, Hacène, Garcia, Vincent, Drouet, Hortense, Philibert, Patrick, Psomas, Christina, Delord, Marion, Retornaz, Frédérique, Charpin, Caroline, Gonzales, Thomas, Pegliasco, Hervé, Allardet-Servent, Jérôme

“…Background & aim We investigated the combination of rapid antigen detection (RAD) and RT-qPCR assays in a stepwise procedure to optimize the detection of…”
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Prediction of oesophageal varices in hepatic cirrhosis by simple serum non-invasive markers: Results of a multicenter, large-scale study by Sebastiani, Giada, Tempesta, Diego, Fattovich, Giovanna, Castera, Laurent, Halfon, Philippe, Bourliere, Marc, Noventa, Franco, Angeli, Paolo, Saggioro, Alfredo, Alberti, Alfredo

“…Background & Aims Preliminary data suggest that non-invasive methods could be useful to assess presence of oesophageal varices (OV) in cirrhotic patients. We…”
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Comparison of ultra-deep versus Sanger sequencing detection of minority mutations on the HIV-1 drug resistance interpretations after virological failure by MOHAMED, Sofiane, PENARANDA, Guillaume, GONZALEZ, Dimitri, CAMUS, Claire, KHIRI, Hacène, BOULME, Ronan, SAYADA, Chalom, PHILIBERT, Patrick, OLIVE, Daniel, HALFON, Philippe

“…Drug-resistance mutations are routinely detected using standard Sanger sequencing, which does not detect minor variants with a frequency below 20%. The impact…”
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How to Measure the Diagnostic Accuracy of Noninvasive Liver Fibrosis Indices: The Area Under the ROC Curve Revisited by Lambert, Jerome, Halfon, Philippe, Penaranda, Guillaume, Bedossa, Pierre, Cacoub, Patrice, Carrat, Fabrice

“…The area under the ROC curve (AUC) is widely used to measure the diagnostic accuracy of noninvasive fibrosis indices. However, use of the AUC assumes a binary…”
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Point-of-Care Versus Central Laboratory Measurements of Hemoglobin, Hematocrit, Glucose, Bicarbonate and Electrolytes: A Prospective Observational Study in Critically Ill Patients by Allardet-Servent, Jérôme, Lebsir, Melissa, Dubroca, Christian, Fabrigoule, Martine, Jordana, Sylvie, Signouret, Thomas, Castanier, Matthias, Thomas, Guillemette, Soundaravelou, Rettinavelou, Lepidi, Anne, Delapierre, Laurence, Penaranda, Guillaume, Halfon, Philippe, Seghboyan, Jean-Marie

“…Rapid detection of abnormal biological values using point-of-care (POC) testing allows clinicians to promptly initiate therapy; however, there are concerns…”
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GlycoFibroTest Is a Highly Performant Liver Fibrosis Biomarker Derived from DNA Sequencer-based Serum Protein Glycomics by Vanderschaeghe, Dieter, Laroy, Wouter, Sablon, Erwin, Halfon, Philippe, Van Hecke, Annelies, Delanghe, Joris, Callewaert, Nico

“…Liver fibrosis is currently assessed by liver biopsy, a costly and rather cumbersome procedure that is unsuitable for frequent patient monitoring, which drives…”
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IL‐22 and IL‐22 binding protein (IL‐22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections by Sertorio, Mathieu, Hou, Xunya, Carmo, Rodrigo F., Dessein, Hélia, Cabantous, Sandrine, Abdelwahed, Mohammed, Romano, Audrey, Albuquerque, Fernanda, Vasconcelos, Luydson, Carmo, Theomira, Li, Jun, Varoquaux, Arthur, Arnaud, Violaine, Oliveira, Pablo, Hamdoun, Anas, He, Hongbin, Adbelmaboud, Suzan, Mergani, Adil, Zhou, Jie, Monis, Ahmed, Pereira, Leila Beltrao, Halfon, Philippe, Bourlière, Marc, Parana, Raymundo, dos Reis, Mitermayer, Gonnelli, David, Moura, Patricia, Elwali, Nasr Eldin, Argiro, Laurent, Li, Yuesheng, Dessein, Alain

“…Interleukin (IL)‐22 acts on epithelia, hepatocytes, and pancreatic cells and stimulates innate immunity, tissue protection, and repair. IL‐22 may also cause…”
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