Search Results - "Halevy, Orna"

Timing Is Everything-The High Sensitivity of Avian Satellite Cells to Thermal Conditions During Embryonic and Posthatch Periods by Halevy, Orna

“…Myofiber formation is essentially complete at hatch, but myofiber hypertrophy increases posthatch through the assimilation of satellite cell nuclei into…”
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Research Note: Prospects for early detection of breast muscle myopathies by automated image analysis by Dayan, Jonathan, Goldman, Noam, Halevy, Orna, Uni, Zehava

“…White Striping (WS), Wooden Breast (WB), and Spaghetti Meat (SM) are documented breast muscle myopathies (BMM) affecting broiler chickens’ product quality,…”
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Thermal manipulation during embryogenesis affects myoblast proliferation and skeletal muscle growth in meat-type chickens by Piestun, Yogev, Yahav, Shlomo, Halevy, Orna

“…Thermal manipulation (TM) of 39.5°C applied during mid-embryogenesis (embryonic d 7 to 16) has been proven to promote muscle development and enhance muscle…”
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A deep learning-based automated image analysis for histological evaluation of broiler pectoral muscle by Dayan, Jonathan, Goldman, Noam, Waiger, Daniel, Melkman-Zehavi, Tal, Halevy, Orna, Uni, Zehava

“…Global market demand for chicken breast muscle with high yield and quality, together with the high incidence rate of breast muscle abnormalities in recent…”
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Early posthatch thermal stress affects breast muscle development and satellite cell growth and characteristics in broilers by Piestun, Yogev, Patael, Tomer, Yahav, Shlomo, Velleman, Sandra G, Halevy, Orna

“…Heat or cold stress, can disrupt well-being and physiological responses in birds. This study aimed to elucidate the effects of continuous heat exposure in the…”
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Thermal manipulations in late-term chick embryos have immediate and longer term effects on myoblast proliferation and skeletal muscle hypertrophy by Piestun, Yogev, Harel, Michal, Barak, Miriam, Yahav, Shlomo, Halevy, Orna

“…1 Department of Animal Sciences, The Hebrew University of Jerusalem, Rehovot; and 2 Institute of Animal Sciences, Agricultural Research Organization, The…”
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Differential Effects of Halofuginone Enantiomers on Muscle Fibrosis and Histopathology in Duchenne Muscular Dystrophy by Mordechay, Sharon, Smullen, Shaun, Evans, Paul, Genin, Olga, Pines, Mark, Halevy, Orna

“…Progressive loss of muscle and muscle function is associated with significant fibrosis in Duchenne muscular dystrophy (DMD) patients. Halofuginone, an analog…”
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Supply and demand of creatine and glycogen in broiler chicken embryos by Dayan, Jonathan, Melkman-Zehavi, Tal, Reicher, Naama, Braun, Ulrike, Inhuber, Vivienne, Mabjeesh, Sameer J, Halevy, Orna, Uni, Zehava

“…Optimal embryonic development and growth of meat-type chickens (broilers) rely on incubation conditions (oxygen, heat, and humidity), on nutrients and on…”
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Sonic hedgehog promotes proliferation and differentiation of adult muscle cells: Involvement of MAPK/ERK and PI3K/Akt pathways by Elia, Dafna, Madhala, Dorit, Ardon, Eti, Reshef, Ram, Halevy, Orna

“…Sonic hedgehog (Shh) has been reported to act as a mitogen and survival factor for muscle satellite cells. However, its role in their differentiation remains…”
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In-ovo feeding with creatine monohydrate: implications for chicken energy reserves and breast muscle development during the pre-post hatching period by Dayan, Jonathan, Melkman-Zehavi, Tal, Goldman, Noam, Soglia, Francesca, Zampiga, Marco, Petracci, Massimiliano, Sirri, Federico, Braun, Ulrike, Inhuber, Vivienne, Halevy, Orna, Uni, Zehava

“…The most dynamic period throughout the lifespan of broiler chickens is the pre-post-hatching period, entailing profound effects on their energy status,…”
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Halofuginone inhibits Smad3 phosphorylation via the PI3K/Akt and MAPK/ERK pathways in muscle cells: Effect on myotube fusion by Roffe, Suzy, Hagai, Yosey, Pines, Mark, Halevy, Orna

“…Halofuginone, a novel inhibitor of Smad3 phosphorylation, has been shown to inhibit muscle fibrosis and to improve cardiac and skeletal muscle functions in the…”
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The effect of temperature on proliferation and differentiation of chicken skeletal muscle satellite cells isolated from different muscle types by Harding, Rachel L., Halevy, Orna, Yahav, Shlomo, Velleman, Sandra G.

“…Skeletal muscle satellite cells are a muscle stem cell population that mediate posthatch muscle growth and repair. Satellite cells respond differentially to…”
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In ovo exposure to monochromatic green light promotes skeletal muscle cell proliferation and affects myofiber growth in posthatch chicks by Halevy, Orna, Piestun, Yogev, Rozenboim, Israel, Yablonka-Reuveni, Zipora

“…Our previous studies demonstrated that illumination of chicken embryos with monochromatic green light results in enhanced body and muscle weight at later…”
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Functional resolution of fibrosis in mdx mouse dystrophic heart and skeletal muscle by halofuginone by Huebner, Kyla D, Jassal, Davinder S, Halevy, Orna, Pines, Mark, Anderson, Judy E

“…The effect of halofuginone (Halo) on established fibrosis in older mdx dystrophic muscle was investigated. Mice (8 to 9 mo) treated with Halo (or saline in…”
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Pattern of Pax7 expression during myogenesis in the posthatch chicken establishes a model for satellite cell differentiation and renewal by Halevy, Orna, Piestun, Yogev, Allouh, Mohammed Z., Rosser, Benjamin W.C., Rinkevich, Yuval, Reshef, Ram, Rozenboim, Israel, Wleklinski‐Lee, Monika, Yablonka‐Reuveni, Zipora

“…The paired‐box transcription factor Pax7 plays a critical role in the specification of satellite cells in mouse skeletal muscle. In the present study, the…”
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Prevention of muscle fibrosis and improvement in muscle performance in the mdx mouse by halofuginone by Turgeman, Tidhar, Hagai, Yosey, Huebner, Kyla, Jassal, Davinder S, Anderson, Judy E, Genin, Olga, Nagler, Arnon, Halevy, Orna, Pines, Mark

“…Abstract Fibrosis is a known feature of dystrophic muscles, particularly the diaphragm, in the mdx mouse. In this study we evaluated the effect of…”
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Fibrosis inhibition and muscle histopathology improvement in laminin-α2-deficient mice by Nevo, Yoram, Halevy, Orna, Genin, Olga, Moshe, Itai, Turgeman, Tidhar, Harel, Michal, Biton, Edva, Reif, Shimon, Pines, Mark

“…In muscular dystrophies (MD) the loss of muscle and its ability to function are associated with fibrosis. We evaluated the efficacy of halofuginone in reducing…”
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Early posthatch starvation decreases satellite cell proliferation and skeletal muscle growth in chicks by Halevy, O, Geyra, A, Barak, M, Uni, Z, Sklan, D

“…The effect of posthatch starvation on skeletal muscle growth and satellite cell proliferation was examined in chicks. Chicks were either fed or starved for 48…”
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Differential regulation of the phosphoinositide 3-kinase and MAP kinase pathways by hepatocyte growth factor vs. insulin-like growth factor-I in myogenic cells by Halevy, Orna, Cantley, Lewis C

“…Hepatocyte growth factor (HGF) promotes the proliferation of adult myoblasts and inhibits their differentiation, whereas insulin-like growth factor I (IGF-I)…”
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Low-energy laser irradiation promotes the survival and cell cycle entry of skeletal muscle satellite cells by Shefer, Gavriella, Partridge, Terry A, Heslop, Louise, Gross, Jacqueline G, Oron, Uri, Halevy, Orna

“…Low energy laser irradiation (LELI) has been shown to promote skeletal muscle cell activation and proliferation in primary cultures of satellite cells as well…”
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