Search Results - "Hales, Tim G"

The 5-HT3 receptor – the relationship between structure and function by Barnes, Nicholas M., Hales, Tim G., Lummis, Sarah C.R., Peters, John A.

“…The 5-hydroxytryptamine type-3 (5-HT3) receptor is a cation-selective ion channel of the Cys-loop superfamily. 5-HT3 receptor activation in the central and…”
Get full text

The impact of adverse childhood experiences on multimorbidity: a systematic review and meta-analysis by Senaratne, Dhaneesha N S, Thakkar, Bhushan, Smith, Blair H, Hales, Tim G, Marryat, Louise, Colvin, Lesley A

“…Adverse childhood experiences (ACEs) have been implicated in the aetiology of a range of health outcomes, including multimorbidity. In this systematic review…”
Get full text

The search for the “next” euphoric non-fentanil novel synthetic opioids on the illicit drugs market: current status and horizon scanning by Sharma, Kirti Kumari, Hales, Tim G., Rao, Vaidya Jayathirtha, NicDaeid, Niamh, McKenzie, Craig

“…Purpose A detailed review on the chemistry and pharmacology of non-fentanil novel synthetic opioid receptor agonists, particularly N -substituted benzamides…”
Get full text

Editorial: Opioids in the time of the COVID-19 pandemic: from cellular mechanisms to public health policy by John, Scott, Walwyn, David R, DeFea, Kathryn, Hales, Tim G, Walwyn, Wendy

Get full text

Src Kinase Inhibition Attenuates Morphine Tolerance without Affecting Reinforcement or Psychomotor Stimulation by Bull, Fiona A, Baptista-Hon, Daniel T, Sneddon, Claire, Wright, Lisa, Walwyn, Wendy, Hales, Tim G

“…Prolonged opioid administration leads to tolerance characterized by reduced analgesic potency. Pain management is additionally compromised by the hedonic…”
Get full text

Pharmacological and nutritional targeting of voltage-gated sodium channels in the treatment of cancers by Lopez-Charcas, Osbaldo, Pukkanasut, Piyasuda, Velu, Sadanandan E., Brackenbury, William J., Hales, Tim G., Besson, Pierre, Gomora, Juan Carlos, Roger, Sébastien

“…Voltage-gated sodium (NaV) channels, initially characterized in excitable cells, have been shown to be aberrantly expressed in non-excitable cancer tissues and…”
Get full text

Cross-sectional study examining the epidemiology of chronic pain in Nepal by Higgins, Cassie, Sharma, Saurab, Bimali, Inosha, Hales, Tim G., Cameron, Paul A., Smith, Blair H., Colvin, Lesley A.

“…The World Health Organization recognizes chronic pain as a global public health concern; however, there is a bias towards research conducted in relatively…”
Get full text

Agonist‐ and antagonist‐induced up‐regulation of surface 5‐HT3A receptors by Morton, Russell A, Baptista‐Hon, Daniel T, Hales, Tim G, Lovinger, David M

“…Background and Purpose The 5‐HT3 receptor is a member of the pentameric ligand‐gated ion channel family and is pharmacologically targeted to treat irritable…”
Get full text

Morphine‐induced mechanical hypersensitivity in mice requires δ receptors, β‐arrestin2, and c‐Src activity by Singleton, Samuel, Hales, Tim G.

“…Morphine diminishes pain, but its long‐term use is compromised by tolerance and hyperalgesia. Studies implicate δ receptors, β‐arrestin2 and Src kinase in…”
Get full text

Tonically active GABAA receptors in hippocampal pyramidal neurons exhibit constitutive GABA-independent gating by McCartney, Melissa R, Deeb, Tarek Z, Henderson, Tricia N, Hales, Tim G

“…Phasic and tonic inhibitory currents of hippocampal pyramidal neurons exhibit distinct pharmacological properties. Picrotoxin and bicuculline methiodide…”
Get more information

Engineering a surrogate human heteromeric α/β glycine receptor orthosteric site exploiting the structural homology and stability of acetylcholine-binding protein by Dawson, Alice, Trumper, Paul, de Souza, Juliana Oliveira, Parker, Holly, Jones, Mathew J, Hales, Tim G, Hunter, William N

“…Protein-engineering methods have been exploited to produce a surrogate system for the extracellular neurotransmitter-binding site of a heteromeric human…”
Get full text

Novel structural determinants of single channel conductance and ion selectivity in 5-hydroxytryptamine type 3 and nicotinic acetylcholine receptors by Peters, John A., Cooper, Michelle A., Carland, Jane E., Livesey, Matthew R., Hales, Tim G., Lambert, Jeremy J.

“…Nicotinic acetylcholine (nACh) and 5-hydroxytryptamine type 3 (5-HT 3 ) receptors are cation-selective ion channels of the pentameric ligand-gated ion channel…”
Get full text

Childhood maltreatment and chronic “all over” body pain in adulthood: a counterfactual analysis using UK Biobank by Timmins, Kate A., Hales, Tim G., Macfarlane, Gary J.

“…Abstract Evidence linking adverse childhood experiences and chronic pain in adulthood is largely cross-sectional, potentially subject to recall bias and does…”
Get full text

A Novel Class of Ligand-gated Ion Channel Is Activated by Zn2 by Davies, Paul A., Wang, Wei, Hales, Tim G., Kirkness, Ewen F.

“…In mammals, the superfamily of “Cys loop,” ligand-gated ion channels (LGICs), is assembled from a pool of more than 40 homologous subunits. These subunits have…”
Get full text

Early-life adversity increases morphine tolerance and persistent inflammatory hypersensitivity through upregulation of δ opioid receptors in mice by Singleton, Sam, Sneddon, Claire, Bakina, Alice, Lambert, Jeremy J., Hales, Tim G.

“…Exposure to severely stressful events during childhood is associated with poor health outcomes in later life, including chronic pain and substance use…”
Get full text

High Affinity Binding of Epibatidine to Serotonin Type 3 Receptors by Drisdel, Renaldo C., Sharp, Douglas, Henderson, Tricia, Hales, Tim G., Green, William N.

“…Epibatidine and mecamylamine are ligands used widely in the study of nicotinic acetylcholine receptors (nAChRs) in the central and peripheral nervous systems…”
Get full text

Structural Determinants of Ca2+ Permeability and Conduction in the Human 5-Hydroxytryptamine Type 3A Receptor by Livesey, Matthew R., Cooper, Michelle A., Deeb, Tarek Z., Carland, Jane E., Kozuska, Janna, Hales, Tim. G., Lambert, Jeremy J., Peters, John A.

“…Cation-selective cysteine (Cys)-loop transmitter-gated ion channels provide an important pathway for Ca2+ entry into neurones. We examined the influence on…”
Get full text

Traumatic needle damage to nerves during regional anesthesia: presentation of a novel mechanotransduction hypothesis by McLeod, Graeme A, Sadler, Amy, Hales, Tim G

“…Despite advances in needle positioning techniques, nerve damage still occurs after regional anesthesia. Recognized causes include local anesthetic toxicity,…”
Get full text

Potent Inactivation-Dependent Inhibition of Adult and Neonatal NaV1.5 Channels by Lidocaine and Levobupivacaine by Elajnaf, Taha, Baptista-Hon, Daniel T, Hales, Tim G

“…BACKGROUND:Cardiotoxic effects of local anesthetics (LAs) involve inhibition of NaV1.5 voltage-gated Na channels. Metastatic breast and colon cancer cells also…”
Get full text

TRV130 partial agonism and capacity to induce anti‐nociceptive tolerance revealed through reducing available μ‐opioid receptor number by Singleton, Samuel, Baptista‐Hon, Daniel T., Edelsten, Emily, McCaughey, Kirsty S., Camplisson, Ewan, Hales, Tim G.

“…Background and Purpose β‐Arrestin2 recruitment to μ‐receptors may contribute to the development of opioid side effects. This possibility led to the development…”
Get full text