Search Results - "Hales, C.N."

Insulin sensitivity and secretion in normal children related to size at birth, postnatal growth, and plasma insulin-like growth factor-I levels by ONG, K. K, PETRY, C. J, EMMETT, P. M, SANDHU, M. S, KIESS, W, HALES, C. N, NESS, A. R, DUNGER, D. B

“…Type 2 diabetes risk is associated with low birth weight, rapid weight gain during childhood, and shorter stature and lower circulating IGF-I levels in adults…”
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Size at birth, maternal weight, and Type 2 diabetes in South India by Fall, C.H.D., Stein, C.E., Kumaran, K., Cox, V., Osmond, C., Barker, D.J.P., Hales, C.N.

“…Recent research in Europe and the USA has shown that adults who had a low birthweight or who were thin at birth with a low ponderal index (birthweight/length3)…”
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Effects of maternal iron restriction in the rat on blood pressure, glucose tolerance, and serum lipids in the 3-month-old offspring by Lewis, R.M., Petry, C.J., Ozanne, S.E., Hales, C.N.

“…Epidemiologic studies have demonstrated associations between low birth weight and increased rates of adult diseases such as hypertension and diabetes. Maternal…”
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Fetal growth and glucose and insulin metabolism in four-year-old Indian children by Yajnik, C S, Fall, C H, Vaidya, U, Pandit, A N, Bavdekar, A, Bhat, D S, Osmond, C, Hales, C N, Barker, D J

“…Studies in Britain have shown that adults who had a low birthweight have high plasma glucose concentrations 30 and 120 min after an oral glucose load, and an…”
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Altered adipocyte properties in the offspring of protein malnourished rats by Shepherd, P.R, Crowther, N.J, Desai, M, Hales, C.N, Ozanne, S.E

“…It is becoming well established that poor fetal and early postnatal growth can have long-term effects on adult health, including susceptibility to…”
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6D-5 Programming of hypothalamic neuropeptide gene expression in rats by early life nutrition by Cripps, R.L, Martin-Gronert, M.S, Archer, Z.A, Hales, C.N, Mercer, J.G, Ozanne, S.E

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Ketosis resistance in the male offspring of protein-malnourished rat dams by Ozanne, S.E., Wang, C.L., Petry, C.J., Smith, J.M., Hales, C.N.

“…Plasma β-hydroxybutyrate concentrations were measured in the offspring of rats that were fed either a control (20% protein) diet or low-protein (8% protein)…”
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Effects of sulphonylureas and diazoxide on insulin secretion and nucleotide‐sensitive channels in an insulin‐secreting cell line by Sturgess, N.C., Kozlowski, R.Z., Carrington, C.A., Hales, C.N., Ashford, M.L.J.

“…1 The effects of various sulphonylureas and diazoxide on insulin secretion and the activity of various channels have been studied using tissue culture and…”
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Reproducibility of the short insulin tolerance test by Hirst, S, Phillips, D I, Vines, S K, Clark, P M, Hales, C N

“…The short insulin tolerance test is a simple method of estimating insulin resistance by measuring the rate of fall of blood glucose following the intravenous…”
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Dual effects of diazoxide on ATP‐K+ currents recorded from an insulin‐secreting cell line by Kozlowski, R.Z., Hales, C.N., Ashford, M.L.J.

“…1 The effects of diazoxide on ATP‐K+ channel currents, recorded from the insulin‐secreting cell line, CRI‐G1, were studied using patch‐clamp techniques. 2…”
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Proinsulin and insulin concentrations following intravenous glucose challenges in normal, obese, and non-insulin-dependent diabetic subjects by Davis, S N, Piatti, P M, Monti, L, Brown, M D, Branch, W, Hales, C N, Alberti, K G

“…We investigated the effects of different intravenous (IV) glucose challenges on insulin and proinsulin secretion. On separate occasions, seven normal controls…”
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Early growth determines longevity in male rats and may be related to telomere shortening in the kidney by Jennings, B.J., Ozanne, S.E., Dorling, M.W., Hales, C.N.

“…Maternal protein undernutrition can influence the growth and longevity of male offspring in the rat. We tested the hypothesis that these differences in…”
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Understanding oral glucose tolerance: comparison of glucose or insulin measurements during the oral glucose tolerance test with specific measurements of insulin resistance and insulin secretion by Phillips, D I, Clark, P M, Hales, C N, Osmond, C

“…The extent to which the oral glucose tolerance test can be used to estimate insulin secretion and insulin resistance has been evaluated by comparing glucose…”
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Lysosomes and prohormone activation by HALES, C.N

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Programming of intermediary metabolism by Petry, C.J., Ozanne, S.E., Hales, C.N.

“…Studies of animal models were carried out to explore mechanisms that might underlie epidemiological findings linking indices of poor early (fetal and early…”
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The 30 minute insulin incremental response in an oral glucose tolerance test as a measure of insulin secretion by Wareham, N J, Phillips, D I, Byrne, C D, Hales, C N

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Altered regulation of hepatic glucose output in the male offspring of protein-malnourished rat dams by Ozanne, S.E. (University of Cambridge, Cambridge, UK.), Smith, G.D, Tikerpae, J, Hales, C.N

“…Offspring of protein-malnourished rat dams have permanent alterations in hepatic enzyme activities associated with glucose homeostasis. Hormonal control of…”
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The effect of maternal body condition score before and during pregnancy on the glucose tolerance of adult sheep offspring by Cripps, Roselle L, Green, Lucy R, Thompson, John, Martin-Gronert, Malgorzata S, Monk, Melanie, Sheldon, I Martin, Hanson, Mark A, Hales, C N, Ozanne, Susan E

“…This study investigates the effects of diet-induced changes in maternal body condition on glucose tolerance in sheep. Welsh Mountain ewes were established, by…”
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Vitamin d receptor gene polymorphisms influence insulin secretion in Bangladeshi Asians by HITMAN, G. A, MANNAN, N, MCDERMOTT, M. F, AGANNA, E, OGUNKOLADE, B. W, HALES, C. N, BOUCHER, B. J

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Adult glucose and lipid metabolism may be programmed during fetal life by Desai, M, Crowther, N J, Ozanne, S E, Lucas, A, Hales, C N

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