Search Results - "Hales, B F"

Characterization of sperm chromatin quality in testicular cancer and Hodgkin's lymphoma patients prior to chemotherapy by O'Flaherty, C., Vaisheva, F., Hales, B.F., Chan, P., Robaire, B.

“…BACKGROUND Although the incidences of testicular cancer and Hodgkin's lymphoma have increased in young men over the past decade, combination chemotherapy has…”
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Exposure of male rats to cyclophosphamide alters the chromatin structure and basic proteome in spermatozoa by Codrington, A.M., Hales, B.F., Robaire, B.

“…BACKGROUND The formation of mature sperm involves the expression of numerous proteins during spermiogenesis and the replacement of histones with protamines to…”
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Effects of in Utero Tributyltin Chloride Exposure in the Rat on Pregnancy Outcome by Adeeko, Adedayo, Li, Daming, Forsyth, Don S., Casey, Valerie, Cooke, Gerard M., Barthelemy, Johanna, Cyr, Daniel G., Trasler, Jacquetta M., Robaire, Bernard, Hales, Barbara F.

“…Tributyltin, an organotin, is ubiquitous in the environment. The consumption of contaminated marine species leads to human dietary exposure to this compound…”
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Effects of endocrine disrupting chemicals on gonad development: Mechanistic insights from fish and mammals by Delbes, G., Blázquez, M., Fernandino, J.I., Grigorova, P., Hales, B.F., Metcalfe, C., Navarro-Martín, L., Parent, L., Robaire, B., Rwigemera, A., Van Der Kraak, G., Wade, M., Marlatt, V.

“…Over the past century, evidence has emerged that endocrine disrupting chemicals (EDCs) have an impact on reproductive health. An increased frequency of…”
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Induction of apoptosis in the germ cells of adult male rats after exposure to cyclophosphamide by CAI, L, HALES, B. F, ROBAIRE, B

“…Treatment with cyclophosphamide, a commonly used anticancer drug, may result in oligozoospermia or azoospermia. The objective of this study was to determine…”
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Thalidomide on the comeback trail by Hales, Barbara F

“…Will new insights into Thalidomide's teratogenic mechanism help make its return a safe one?…”
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Expression of Stress Response Genes in Germ Cells During Spermatogenesis by AGUILAR-MAHECHA, Adriana, HALES, Barbara F, ROBAIRE, Bernard

“…During germ cell development different spermatogenic cell types show remarkable variation in their susceptibility to stressful stimuli. Various cellular…”
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Damage to rat spermatozoal DNA after chronic cyclophosphamide exposure by QIU, J, HALES, B. F, ROBAIRE, B

“…Treatment of male rats with low dosages of cyclophosphamide causes a dramatic increase in early embryo death among their progeny without significantly…”
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The effects of chemotherapy with bleomycin, etoposide, and cis‐platinum on telomeres in rat male germ cells by Liu, M., Maselli, J., Hales, B. F., Robaire, B.

“…Summary Co‐administration of bleomycin, etoposide, and cis‐platinum (BEP) has increased the 5‐year survival rate of testis cancer patients to over 90%;…”
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Antisense oligonucleotide down-regulation of E-cadherin in the yolk sac and cranial neural tube malformations by Chen, B, Hales, B F

“…The cadherins are a family of calcium-dependent cell adhesion molecules that are regulated both spatially and temporally during development. Epithelial…”
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Effects of chronic low-dose cyclophosphamide exposure on the nuclei of rat spermatozoa by JIANPING QIU, HALES, B. F, ROBAIRE, B

“…Previous studies from our laboratory have shown that chronic exposure of the father to low doses of cyclophosphamide results in a significant increase in early…”
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Paternal exposure to testis cancer chemotherapeutics alters sperm fertilizing capacity and affects gene expression in the eight‐cell stage rat embryo by Maselli, J., Hales, B. F., Robaire, B.

“…Summary Treatment of testicular cancer includes the coadministration of bleomycin, etoposide and cis‐platinum (BEP); however, along with its therapeutic…”
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Paternal Exposure to Cyclophosphamide Alters Cell-Cell Contacts and Activation of Embryonic Transcription in the Preimplantation Rat Embryo by HARROUK, W, ROBAIRE, B, HALES, B. F

“…Paternal exposure to chronic low doses of cyclophosphamide, an anticancer agent, results in aberrant embryonic development of the progeny. We hypothesized that…”
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Chronic low dose cyclophosphamide treatment of adult male rats: effect on fertility, pregnancy outcome and progeny by TRASLER, J. M, HALES, B. F, ROBAIRE, B

“…Cyclophosphamide is an anticancer and immunosuppressive agent commonly used in men of reproductive age. The relationship between the effects of paternal…”
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Critical Windows of Exposure for Children's Health: The Reproductive System in Animals and Humans by Pryor, Jon L., Hughes, Claude, Foster, Warren, Hales, Barbara F., Robaire, Bernard

“…Drugs and environmental chemicals can adversely affect the reproductive system. Currently, available data indicate that the consequences of exposure depend on…”
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Impact of Paternal Exposure to Chemotherapy on Offspring in the Rat by Hales, Barbara F., Barton, Tara S., Robaire, Bernard

“…Paternal exposure to chemotherapeutics may have adverse effects on offspring. In the rat, chronic low-dose paternal exposure to the anticancer drug…”
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Transglutaminase and clusterin induction during normal and abnormal limb development in the mouse by ADEL MOALLEM, S, HALES, B. F

“…Apoptotic cell death is important in pattern formation in the limb. The purpose of this study was to investigate the relationship between the occurrence of…”
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Paternal cyclophosphamide exposure causes decreased cell proliferation in cleavage-stage embryos by KELLY, S. M, ROBAIRE, B, HALES, B. F

“…Exposure of the male germ cell to cyclophosphamide during spermatogenesis and sperm maturation can interfere with development of the embryo. When male rats…”
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Tissue-specific regulation of glutathione homeostasis and the activator protein-1 (AP-1) response in the rat conceptus by Ozolins̆, Terence R.S, Hales, Barbara F

“…Oxidative stress in the conceptus is characterized by an increased oxidized to reduced glutathione (GSSG:GSH) ratio and the induction of fos and jun mRNAs,…”
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Adverse effects of cyclophosphamide on progeny outcome can be mediated through post-testicular mechanisms in the rat by Qiu, J, Hales, B F, Robaire, B

“…Previous studies from our laboratory have suggested that, in addition to an effect on spermatozoa in the testis, cyclophosphamide may have an adverse effect on…”
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