Search Results - "Halem, Heather A."

TBR-760, a Dopamine-Somatostatin Compound, Arrests Growth of Aggressive Nonfunctioning Pituitary Adenomas in Mice by Halem, Heather A, Hochgeschwender, Ute, Rih, Jeong Keun, Nelson, Richard, Johnson, G Allan, Thiagalingam, Arunthi, Culler, Michael D

“…Abstract TBR-760 (formerly BIM-23A760) is a chimeric dopamine (DA)-somatostatin (SST) compound with potent agonist activity at both DA type 2 (D2R) and SST…”
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Ghrelin Treatment Causes Increased Food Intake and Retention of Lean Body Mass in a Rat Model of Cancer Cachexia by DeBoer, Mark D, Zhu, Xin Xia, Levasseur, Peter, Meguid, Michael M, Suzuki, Susumu, Inui, Akio, Taylor, John E, Halem, Heather A, Dong, Jesse Z, Datta, Rakesh, Culler, Michael D, Marks, Daniel L

“…Cancer cachexia is a debilitating syndrome of anorexia and loss of lean body mass that accompanies many malignancies. Ghrelin is an orexigenic hormone with a…”
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Ghrelin Treatment of Chronic Kidney Disease: Improvements in Lean Body Mass and Cytokine Profile by DeBoer, Mark D, Zhu, Xinxia, Levasseur, Peter R, Inui, Akio, Hu, Zhaoyong, Han, Guofeng, Mitch, William E, Taylor, John E, Halem, Heather A, Dong, Jesse Z, Datta, Rakesh, Culler, Michael D, Marks, Daniel L

“…Chronic kidney disease (CKD) is associated with an increase in inflammatory cytokines and can result in cachexia with loss of muscle and fat stores. We…”
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Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice by Kumar, K. Ganesh, Sutton, Gregory M., Dong, Jesse Z., Roubert, Pierre, Plas, Pascale, Halem, Heather A., Culler, Michael D., Yang, Hyunwon, Dixit, Vishwa D., Butler, Andrew A.

“…Melanocortin receptor agonists act in the brain to regulate food intake and body weight and, independently of these actions, affect insulin sensitivity. These…”
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Sex Difference and Steroid Modulation of Pheromone-Induced Immediate Early Genes in the Two Zones of the Mouse Accessory Olfactory System by Halem, Heather A, Baum, Michael J, Cherry, James A

“…Two anatomically and neurochemically distinct zones within the vomeronasal organ (VNO) and accessory olfactory bulb (AOB) have been identified that are…”
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Identification of Adropin as a Secreted Factor Linking Dietary Macronutrient Intake with Energy Homeostasis and Lipid Metabolism by Kumar, K. Ganesh, Trevaskis, James L., Lam, Daniel D., Sutton, Gregory M., Koza, Robert A., Chouljenko, Vladimir N., Kousoulas, Konstantin G., Rogers, Pamela M., Kesterson, Robert A., Thearle, Marie, Ferrante, Anthony W., Mynatt, Randall L., Burris, Thomas P., Dong, Jesse Z., Halem, Heather A., Culler, Michael D., Heisler, Lora K., Stephens, Jacqueline M., Butler, Andrew A.

“…Obesity and nutrient homeostasis are linked by mechanisms that are not fully elucidated. Here we describe a secreted protein, adropin, encoded by a gene,…”
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Characterization of the ability of a, second-generation SST-DA chimeric molecule, TBR-065, to suppress GH secretion from human GH-secreting adenoma cells by Cuny, Thomas, Graillon, Thomas, Defilles, Célines, Datta, Rakesh, Zhang, Shengwen, Figarella-Branger, Dominique, Dufour, Henry, Mougel, Grégory, Brue, Thierry, Landsman, Tanya, Halem, Heather A., Culler, Michael D., Barlier, Anne, Saveanu, Alexandru

“…Context Somatostatin (SST) and dopamine (DA) inhibit growth hormone (GH) secretion and proliferation of GH-secreting pituitary adenomas (GHomas) through…”
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Adamantyl carboxamides and acetamides as potent human 11β-hydroxysteroid dehydrogenase type 1 inhibitors by Su, Xiangdong, Halem, Heather A., Thomas, Mark P., Moutrille, Cecile, Culler, Michael D., Vicker, Nigel, Potter, Barry V.L.

“…Series of adamantyl carboxamide and acetamide derivatives were identified, providing potent and selective inhibitors of the therapeutic target human…”
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A novel growth hormone secretagogue-1a receptor antagonist that blocks ghrelin-induced growth hormone secretion but induces increased body weight gain by Halem, Heather A, Taylor, John E, Dong, Jesse Z, Shen, Yeelana, Datta, Rakesh, Abizaid, Alfonso, Diano, Sabrina, Horvath, Tamas L, Culler, Michael D

“…Ghrelin, the natural ligand for the growth hormone secretagogue-1a (GHS-1a) receptor, has received a great deal of attention due to its ability to stimulate…”
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Novel analogs of ghrelin: physiological and clinical implications by Halem, HA, Taylor, JE, Dong, JZ, Shen, Y, Datta, R, Abizaid, A, Diano, S, Horvath, T, Zizzari, P, Bluet-Pajot, MT, Epelbaum, J, Culler, MD

“…Ghrelin, the 28 amino acid peptide recently identified as the natural ligand for the growth hormone (GH) secretagogue (GHS) receptor, has multiple activities…”
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Discovery of Adamantyl Ethanone Derivatives as Potent 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitors by Su, Xiangdong, Pradaux-Caggiano, Fabienne, Thomas, Mark P., Szeto, Michelle W. Y., Halem, Heather A., Culler, Michael D., Vicker, Nigel, Potter, Barry V. L.

“…11β‐Hydroxysteroid dehydrogenases (11β‐HSDs) are key enzymes regulating the pre‐receptor metabolism of glucocorticoid hormones. The modulation of 11β‐HSD type…”
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Novel melanocortin-4 receptor agonists that decrease food intake and body weight by Dong, Jesse Z, DeOliveira, Daniel B, Halem, Heather A, Taylor, John E, Roubert, Pierre, Plas, Pascale, Culler, Michael D, Zhang, Jundong

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GHS-1a agonists that effectively stimulate food intake and body weight gain by Dong, Jesse Z, Zhang, Jundong, Taylor, John E, Halem, Heather A, Datta, Rakesh, Culler, Michael D, Eynon, John

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Glucocorticoid inhibition of growth in rats: partial reversal with the full-length ghrelin analog BIM-28125 by Tulipano, Giovanni, Taylor, John E, Halem, Heather A, Datta, Rakesh, Dong, Jesse Z, Culler, Michael D, Bianchi, Irene, Cocchi, Daniela, Giustina, Andrea

“…Glucocorticoids are important immunosuppressive hormones; these steroids also inhibit somatic growth by decreased growth hormone (GH) secretion and induced…”
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Central forebrain Fos responses to familiar male odours are attenuated in recently mated female mice by Halem, H A, Cherry, J A, Baum, M J

“…Exposure of recently mated female mice to the urinary odours of an unfamiliar male blocks pregnancy (the Bruce effect). The absence of a pregnancy block in…”
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OR06-02 TBR-760, a Chimeric Somatostatin-Dopamine Compound, Arrests Aggressive Non-Functioning Pituitary Adenoma Growth In Vivo by Halem, Heather A, Hochgeschwender, Ute, Thiagalingam, Arunthi, Culler, Michael D

“…TBR-760 is a chimeric dopamine (DA)-somatostatin (SST) compound with potent agonist activity at both DA type 2 (D2R; EC50 0.064nM) and SST type 2 (SSTR2; EC50…”
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Central forebrain Fos responses to familiar male odours are attenuated in recently mated female mice by Halem, Heather A., Cherry, James A., Baum, Michael J.

“…Exposure of recently mated female mice to the urinary odours of an unfamiliar male blocks pregnancy (the Bruce effect). The absence of a pregnancy block in…”
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Discovery of adamantyl ethanone derivatives as potent 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors by Su, Xiangdong, Pradaux-Caggiano, Fabienne, Thomas, Mark P, Szeto, Michelle W Y, Halem, Heather A, Culler, Michael D, Vicker, Nigel, Potter, Barry V L

“…11Beta-hydroxysteroid dehydrogenases (11beta-HSDs) are key enzymes regulating the pre-receptor metabolism of glucocorticoid hormones. The modulation of…”
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Novel analogs of ghrelin: physiological and clinical implications: Growth Hormone Update : From Basic Research to Novel Clinical Applications by HALEM, Heather A, TAYLOR, John E, EPELBAUM, Jacques, CULLER, Michael D, DONG, Jesse Z, SHEN, Yeelana, DATTA, Rakesh, ABIZAID, Alfonso, DIANO, Sabrina, HORVATH, Tamas, ZIZZARI, Philiope, BLUET-PAJOT, Marie-Therese

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