Search Results - "Hale, Stephen"

The exploration of macrocycles for drug discovery - an underexploited structural class by Terrett, Nicholas K, Driggers, Edward M, Hale, Stephen P, Lee, Jinbo

“…Key Points Macrocyclic natural products have evolved to fulfil numerous biochemical functions, and their pharmacological properties have led to their…”
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The SNARE Protein Syntaxin-1a Plays an Essential Role in Biphasic Exocytosis of the Incretin Hormone Glucagon-Like Peptide 1 by Wheeler, Sarah E, Stacey, Holly M, Nahaei, Yasaman, Hale, Stephen J, Hardy, Alexandre B, Reimann, Frank, Gribble, Fiona M, Larraufie, Pierre, Gaisano, Herbert Y, Brubaker, Patricia L

“…Exocytosis of the hormone glucagon-like peptide 1 (GLP-1) by the intestinal L cell is essential for the incretin effect after nutrient ingestion and is…”
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Biogeographical Patterns of Marine Benthic Macroinvertebrates Along the Atlantic Coast of the Northeastern USA by Hale, Stephen S.

“…The biogeography of marine benthic macroinvertebrates of US Atlantic estuaries and inshore coastal areas from Delaware Bay north to Passamaquoddy Bay was…”
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DNA-encoded chemical libraries of macrocycles by Connors, William H, Hale, Stephen P, Terrett, Nicholas K

“…•Generation of macrocyclic libraries using DNA-encoded chemistry.•Modulating protein–protein interactions.•Library design based on known peptide…”
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Six decades of change in pollution and benthic invertebrate biodiversity in a southern New England estuary by Hale, Stephen S., Buffum, Henry W., Hughes, Melissa M.

“…Pollution has led to a decline of benthic invertebrate biodiversity of Narragansett Bay, raising questions about effects on ecosystem functions and services…”
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Historical Trends of Benthic Invertebrate Biodiversity Spanning 182 Years in a Southern New England Estuary by Hale, Stephen S., Hughes, Melissa M., Buffum, Henry W.

“…Benthic invertebrates support numerous ecosystem functions and services including shellfish production, energy flow to fishes, and biogeochemical cycles. The…”
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Subtidal Benthic Invertebrates Shifting Northward Along the US Atlantic Coast by Hale, Stephen S., Buffum, Henry W., Kiddon, John A., Hughes, Melissa M.

“…Numerous marine and terrestrial species have shifted their ranges poleward in response to warming from global climate change. However, few studies have…”
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Eutrophication and Hypoxia Diminish Ecosystem Functions of Benthic Communities in a New England Estuary by Hale, Stephen S., Cicchetti, Giancarlo, Deacutis, Christopher F.

“…Excessive input of nitrogen to estuaries and coastal waters leads to eutrophication; the resulting organic matter over-enrichment of sediments and seasonal…”
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Implementation and facilitation of post-resuscitation debriefing: a comparative crossover study of two post-resuscitation debriefing frameworks by Kam, April J, Gonsalves, Clarelle L, Nordlund, Samantha V, Hale, Stephen J, Twiss, Jennifer, Cupido, Cynthia, Brar, Mandeep, Parker, Melissa J

“…Background Post-resuscitation debriefing (PRD) is the process of facilitated, reflective discussion, enabling team-based interpersonal feedback and…”
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Side Effects May Include Fun: Pre- and Post-Market Surveillance of the GridlockED Serious Game by Hale, Stephen J., Wakeling, Sonja, Blain, J. Bruce, Pardhan, Alim, Mondoux, Shawn, Chan, Teresa M.

“…Introduction. As serious games are a relatively new phenomenon in medical education, there is little data on end user demographics or usage. In this study our…”
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Benthic macroinvertebrate community response to environmental changes over seven decades in an urbanized estuary in the northeastern United States by Pelletier, Marguerite, Cobb, Donald, Rocha, Kenneth, Ho, Kay T., Cantwell, Mark G., Perron, Monique, Charpentier, Michael A., Buffum, Henry W., Hale, Stephen S., Burgess, Robert M.

“…Narragansett Bay is representative of New England, USA urbanized estuaries, with colonization in the early 17th century, and development into industrial and…”
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Feeling the flow with a serious game workshop: GridlockED as Medical Education 2 study (GAME2 study) by Hale, Stephen J., Wakeling, Sonja, Bhalerao, Anuja, Balakumaran, Janatani, Huang, Simon, Mondoux, Shawn, Blain, J. Bruce, Chan, Teresa M.

“…Objective GridlockED gameplay workshops were delivered in Canada. This project investigated workshop attendees’ experiences, seeking to identify learning…”
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Applications of Postresuscitation Debriefing Frameworks in Emergency Settings: A Systematic Review by Hale, Stephen J., Parker, Melissa J., Cupido, Cynthia, Kam, April J., Clarke, Sam

“…Objectives Postresuscitation debriefing (PRD) is a valuable educational tool in emergency medicine. It is recommended by international resuscitation…”
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Beyond data management: how ecoinformatics can benefit environmental monitoring programs by Hale, Stephen S, Hollister, Jeffrey W

“…We review ways in which the new discipline of ecoinformatics is changing how environmental monitoring data are managed, synthesized, and analyzed. Rapid…”
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Management Relevance of Benthic Biogeography at Multiple Scales in Coastal Waters of the Northeast U.S by Hale, Stephen S., Coté, Melville P., Tedesco, Mark A., Searfoss, Renee

“…Continuing pressures from human activities have harmed the health of ocean ecosystems, particularly those near the coast. Current management practices that…”
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Aminoacylation error correction by Lin, Laura, Hale, Stephen P, Schimmel, Paul

“…The amino-acid/trinucleotide relationships of the universal genetic code are established in aminoacylation reactions catalyzed by transfer RNA (tRNA)…”
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In Praise of Mud by Hale, Stephen S.

“…Photosynthetic sulfur bacteria on the surface of salt marshes oxidize hydrogen sulfide diffusing up from lower layers, lessening the rotten egg smell. Tidal…”
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USING SATELLITE IMAGERY TO MODEL DISTRIBUTION AND ABUNDANCE OF BICKNELL'S THRUSH (CATHARUS BICKNELLI) IN NEW HAMPSHIRE'S WHITE MOUNTAINS by Hale, Stephen R

“…Satellite imagery was used to model the distribution and abundance of Bicknell's Thrush (Catharus bicknelli) in the White Mountains of New Hampshire…”
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Signals from the benthos: Development and evaluation of a benthic index for the nearshore Gulf of Maine by Hale, Stephen S., Heltshe, James F.

“…We developed a benthic index for the nearshore Gulf of Maine to provide researchers and environmental managers a way to make spatial and year-to-year…”
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Watershed Landscape Indicators of Estuarine Benthic Condition by Hale, Stephen S., Paul, John F., Heltshe, James F.

“…Do land use and cover characteristics of watersheds associated with small estuaries exhibit a strong enough signal to make landscape metrics useful for…”
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