Search Results - "Hale, Sharon L"

New and revisited approaches to preserving the reperfused myocardium by Kloner, Robert A., Brown, David A., Csete, Marie, Dai, Wangde, Downey, James M., Gottlieb, Roberta A., Hale, Sharon L., Shi, Jianru

“…Key Points Mortality after acute ST-segment elevation myocardial infarction (STEMI) has plateaued in the past decade, after a period of continual decline…”
Get full text

Testosterone and the Cardiovascular System: A Comprehensive Review of the Basic Science Literature by Herring, Michael J., Oskui, Peyman Mesbah, Hale, Sharon L., Kloner, Robert A.

Get full text

Therapeutic Hypothermia for Acute Myocardial Infarction and Cardiac Arrest by Schwartz, Bryan G., MD, Kloner, Robert A., MD, PhD, Thomas, Joseph L., MD, Bui, Quang, MD, Mayeda, Guy S., MD, Burstein, Steven, MD, Hale, Sharon L., BS, Economides, Christina, MD, French, William J., MD

“…This report focuses on cardioprotection and describes the advantages and disadvantages of various methods of inducing therapeutic hypothermia (TH) with regard…”
Get full text

Survival and maturation of human embryonic stem cell-derived cardiomyocytes in rat hearts by Dai, Wangde, Field, Loren J, Rubart, Michael, Reuter, Sean, Hale, Sharon L, Zweigerdt, Robert, Graichen, Ralph E, Kay, Gregory L, Jyrala, Aarne J, Colman, Alan, Davidson, Bruce P, Pera, Martin, Kloner, Robert A

“…Abstract Human embryonic stem cell (hESC)-derived cardiomyocytes are a promising cell source for cardiac repair. Whether these cells can be transported long…”
Get full text

Mild hypothermia as a cardioprotective approach for acute myocardial infarction: laboratory to clinical application by Hale, Sharon L, Kloner, Robert A

“…In many animal models, mild therapeutic hypothermia is a powerful intervention, reducing myocardial infarct size, reducing the no-reflow phenomenon, and…”
Get more information

Improved left ventricular function and reduced necrosis after myocardial ischemia/reperfusion in rabbits treated with ranolazine, an inhibitor of the late sodium channel by Hale, Sharon L, Leeka, Justin A, Kloner, Robert A

“…Ranolazine is an inhibitor of the late sodium current and, via this mechanism, decreases sodium-dependent intracellular calcium overload during ischemia and…”
Get more information

Role of a paracrine action of mesenchymal stem cells in the improvement of left ventricular function after coronary artery occlusion in rats by Dai, Wangde, Hale, Sharon L, Kloner, Robert A

“…We aimed to determine whether soluble factors released by cultured mesenchymal stem cells (MSCs) improved cardiac function in an experimental model of…”
Get more information

Ranolazine as a Cardioplegia Additive Improves Recovery of Diastolic Function in Isolated Rat Hearts by HWANG, Hyosook, ARCIDI, Joseph M, HALE, Sharon L, SIMKHOVICH, Boris Z, BELARDINELLI, Luiz, DHALLA, Arvinder K, SHRYOCK, John C, KLONER, Robert A

“…Ranolazine (Ran), an antianginal agent, inhibits late Na(+) current. The purpose of this study was to determine whether there was an added benefit of adding…”
Get full text

Capsaicin-Induced Cardioprotection. Is Hypothermia or the Salvage Kinase Pathway Involved? by Dow, Joan, Simkhovich, Boris Z., Hale, Sharon L., Kay, Gregory, Kloner, Robert A.

“…Purpose Topical capsaicin application was shown to reduce infarct size in experimental animal models. We hypothesized that cardioprotective properties of…”
Get full text

Granulocyte Colony-Stimulating Factor and Stem Cell Factor Improve Contractile Reserve of the Infarcted Left Ventricle Independent of Restoring Muscle Mass by Sesti, Casilde, Hale, Sharon L., Lutzko, Carolyn, Kloner, Robert A.

“…Granulocyte Colony-Stimulating Factor and Stem Cell Factor Improve Contractile Reserve of the Infarcted Left Ventricle Independent of Restoring Muscle Mass…”
Get full text

Bendavia restores mitochondrial energy metabolism gene expression and suppresses cardiac fibrosis in the border zone of the infarcted heart by Shi, Jianru, Dai, Wangde, Hale, Sharon L., Brown, David A., Wang, Miao, Han, Xianlin, Kloner, Robert A.

“…We have observed that Bendavia, a mitochondrial-targeting peptide that binds the phospholipid cardiolipin and stabilizes the components of electron transport…”
Get full text

Bendavia, a Mitochondria-targeting Peptide, Improves Postinfarction Cardiac Function, Prevents Adverse Left Ventricular Remodeling, and Restores Mitochondria-related Gene Expression in Rats by Dai, Wangde, Shi, Jianru, Gupta, Ramesh C, Sabbah, Hani N, Hale, Sharon L, Kloner, Robert A

“…We evaluated the post-myocardial infarction (MI) therapeutic effects of Bendavia. Two hours after coronary artery ligation, rats were randomized to receive…”
Get full text

Cardioprotection: Where to from here? by Kloner, Robert A., Hale, Sharon L., Dai, Wangde, Shi, Jianru

“…The size of the myocardial infarction remains an important therapeutic target, because heart attack size correlates with mortality and heart failure. In this…”
Get full text

Myocardial hypothermia induced after reperfusion does not prevent adverse left ventricular remodeling nor improve cardiac function by Shi, Jianru, Dai, Wangde, Carreno, Juan, Hale, Sharon L., Kloner, Robert A., Kay, Gregory L.

“…The purpose of the study was to determine whether late therapeutic hypothermia (LTH), administered after reperfusion, could prevent adverse left ventricular…”
Get full text

Late sodium current inhibition as a new cardioprotective approach by Hale, Sharon L, Shryock, John C, Belardinelli, Luiz, Sweeney, Michael, Kloner, Robert A

“…Abstract There is increasing evidence that the late sodium current of the sodium channel in myocytes plays a critical role in the pathophysiology of myocardial…”
Get full text

Allogeneic mesenchymal stem cell transplantation in postinfarcted rat myocardium : Short- and long-term effects by WANGDE DAI, HALE, Sharon L, MARTIN, Bradley J, KUANG, Jin-Qiang, DOW, Joan S, WOLD, Loren E, KLONER, Robert A

“…Mesenchymal stem cells (MSCs) have the potential to replace infarct scar, but the long-term effects are unknown. We studied short- and long-term effects of MSC…”
Get full text

Administration of Erythropoietin Fails to Improve Long-Term Healing or Cardiac Function After Myocardial Infarction in the Rat by Hale, Sharon L, Sesti, Casilde, Kloner, Robert A

“…Erythropoietin (epo), initially recognized and used clinically to increase erythropoiesis, has been shown to have beneficial effects on various other tissues…”
Get full text

Potential for stem cell-derived biologic pumps for cardiovascular and other medical therapies by Kloner, Robert A, Hale, Sharon L, Dai, Wangde

“…Studies alleging that intrinsic adult cardiac stem cells or bone marrow-derived stem cells can result in transformation to new cardiac muscle have now largely…”
Get full text

Improved Long-term Survival with Remote Limb Ischemic Preconditioning in a Rat Fixed-Pressure Hemorrhagic Shock Model by Dai, Wangde, Shi, Jianru, Carreno, Juan, Hale, Sharon L., Kloner, Robert A.

“…Purpose We investigated whether bilateral, lower limb remote ischemic preconditioning (RIPC) improved long-term survival using a rat model of hemorrhagic…”
Get full text

No-Reflow Phenomenon. A New Target for Therapy of Acute Myocardial Infarction Independent of Myocardial Infarct Size by Kloner, Robert A, Dai, Wangde, Hale, Sharon L

Get more information