Search Results - "Hale, SL"

Acetaminophen and myocardial stunning after transient ischemia in rabbit hearts by Hale, Sharon L, Kloner, Robert A

“…Myocardial stunning is a lingering contractile dysfunction that occurs after brief ischemia, even in the absence of necrosis. Recent studies have shown that…”
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Allogeneic mesenchymal stem cell transplantation in postinfarcted rat myocardium : Short- and long-term effects by WANGDE DAI, HALE, Sharon L, MARTIN, Bradley J, KUANG, Jin-Qiang, DOW, Joan S, WOLD, Loren E, KLONER, Robert A

“…Mesenchymal stem cells (MSCs) have the potential to replace infarct scar, but the long-term effects are unknown. We studied short- and long-term effects of MSC…”
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Ranolazine Treatment for Myocardial Infarction? Effects on the Development of Necrosis, Left Ventricular Function and Arrhythmias in Experimental Models by Hale, Sharon L, Kloner, Robert A

“…Ranolazine, an inhibitor of the late current of the cardiac action potential (late I Na ), is a well established clinical treatment for chronic angina. The…”
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Quantitative Real-Time RT-PCR Analysis of Inflammatory Gene Expression Associated With Ischemia-Reperfusion Brain Injury by Berti, Rossana, Williams, Anthony J., Moffett, John R., Hale, Sarah L., Velarde, Luisa C., Elliott, Peter J., Yao, Changping, Dave, Jitendra R., Tortella, Frank C.

“…Ischemia-reperfusion brain injury initiates an inflammatory response involving the expression of adhesion molecules and cytokines, some of which are regulated…”
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Hypothermia during reperfusion limits 'no-reflow' injury in a rabbit model of acute myocardial infarction by HALE, Sharon L, DAE, Michael W, KLONER, Robert A

“…Reflow following coronary artery occlusion is an important predictor of clinical outcome. This study tests the effects of regional hypothermia, initiated late…”
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No-reflow phenomenon persists long-term after ischemia/reperfusion in the rat and predicts infarct expansion by REFFELMANN, Thorsten, HALE, Sharon L, DOW, Joan S, KLONER, Robert A

“…No-reflow after reperfusion therapy for myocardial infarction is a strong predictor of clinical outcome. But its fate on a long-term basis and potential…”
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Ischemic preconditioning at a distance : Reduction of myocardial infarct size by partial reduction of blood supply combined with rapid stimulation of the gastrocnemius muscle in the rabbit by BIRNBAUM, Y, HALE, S. L, KLONER, R. A

“…Limitation of myocardial infarct size by an earlier brief complete occlusion of a coronary artery is defined as ischemic preconditioning. However, myocardial…”
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Capsaicin-Induced Cardioprotection. Is Hypothermia or the Salvage Kinase Pathway Involved? by Dow, Joan, Simkhovich, Boris Z., Hale, Sharon L., Kay, Gregory, Kloner, Robert A.

“…Purpose Topical capsaicin application was shown to reduce infarct size in experimental animal models. We hypothesized that cardioprotective properties of…”
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Relationship between no reflow and infarct size as influenced by the duration of ischemia and reperfusion by Reffelmann, Thorsten, Hale, Sharon L, Li, Guohu, Kloner, Robert A

“…No reflow after acute myocardial infarction is an important predictor of infarct size and clinical outcome. However, the exact relationship between no reflow…”
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Granulocyte Colony-Stimulating Factor and Stem Cell Factor Improve Contractile Reserve of the Infarcted Left Ventricle Independent of Restoring Muscle Mass by Sesti, Casilde, Hale, Sharon L., Lutzko, Carolyn, Kloner, Robert A.

“…Granulocyte Colony-Stimulating Factor and Stem Cell Factor Improve Contractile Reserve of the Infarcted Left Ventricle Independent of Restoring Muscle Mass…”
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Delayed Treatment with MLN519 Reduces Infarction and Associated Neurologic Deficit Caused by Focal Ischemic Brain Injury in Rats via Antiinflammatory Mechanisms Involving Nuclear Factor-κB Activation, Gliosis, and Leukocyte Infiltration by Williams, Anthony J., Hale, Sarah L., Moffett, John R., Dave, Jitendra R., Elliott, Peter J., Adams, Julian, Tortella, Frank C.

“…Secondary brain injury due to ischemia includes the infiltration of leukocytes into the brain parenchyma mediated by activation of nuclear factor-κB (NF-κB),…”
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Transplantation of neonatal cardiomyocytes after permanent coronary artery occlusion increases regional blood flow of infarcted myocardium by Reffelmann, Thorsten, Dow, Joan S., Dai, Wangde, Hale, Sharon L., Simkhovich, Boris Z., Kloner, Robert A.

“…Background. – Cellular cardiomyoplasty is a promising approach for rebuilding scar tissue after acute myocardial infarction. However, the angiogenic potential…”
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Myocardial temperature in acute myocardial infarction: protection with mild regional hypothermia by Hale, S L, Kloner, R A

“…This study tests the hypothesis that a 2-4 degrees C reduction in myocardial temperature, obtained by using topical regional hypothermia (TRH), reduces infarct…”
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Long-term outcome of fetal cell transplantation on postinfarction ventricular remodeling and function by Yao, Mu, Dieterle, Thomas, Hale, Sharon L., Dow, Joan S., Kedes, Laurence H., Peterson, Kirk L., Kloner, Robert A.

“…Objectives. – The purpose of this study was to determine the long-term outcome of fetal cell transplantation into myocardial infarction on left ventricular…”
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Administration of Erythropoietin Fails to Improve Long-Term Healing or Cardiac Function After Myocardial Infarction in the Rat by Hale, Sharon L, Sesti, Casilde, Kloner, Robert A

“…Erythropoietin (epo), initially recognized and used clinically to increase erythropoiesis, has been shown to have beneficial effects on various other tissues…”
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Stem cell transplantation for the treatment of myocardial infarction by Dai, Wangde, Hale, Sharon L., Kloner, Robert A.

“…Stem cell transplantation provides a potential regenerative therapy for the heart damaged by myocardial infarction. Numerous scientific studies have been…”
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Metabolic mechanism by which mild regional hypothermia preserves ischemic tissue by Simkhovich, Boris Z, Hale, Sharon L, Kloner, Robert A

“…Our laboratory demonstrated that mild regional hypothermia reduced myocardial infarct size by an average of 65% in the rabbit model of regional ischemia. The…”
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α-Adrenoceptor stimulation with exogenous norepinephrine or release of endogenous catecholamines mimics ischemic preconditioning by BANKWALA, Z, HALE, S. L, KLONER, R. A

“…Brief episodes of ischemia induced by proximal coronary artery occlusion can precondition the myocardium. Whether other stressful stimuli have the potential to…”
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β-Estradiol, but not α-estradiol, reduces myocardial necrosis in rabbits after ischemia and reperfusion by Hale, Sharon L., Birnbaum, Yochai, Kloner, Robert A.

“…Recent studies in several animal models have suggested that estrogen, given for the short term, may protect ischemic myocardium. Our objective was to test the…”
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Implantation of immature neonatal cardiac cells into the wall of the aorta in rats: a novel model for studying morphological and functional development of heart cells in an extracardiac environment by Dai, Wangde, Hale, Sharon L, Kloner, Robert A

“…Morphological and functional development of implanted neonatal cardiac cells in the wall of the abdominal aorta in rats was investigated. Cardiomyocytes from…”
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