Search Results - "Hale, Preston"
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Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice
Published in Blood (17-01-2019)“…Cerebral cavernous malformations (CCMs) are common brain vascular dysplasias that are prone to acute and chronic hemorrhage with significant clinical sequelae…”
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Inhibition of the HEG1–KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells
Published in FASEB bioAdvances (01-05-2021)“…ABSTRACT The transmembrane protein heart of glass1 (HEG1) directly binds to and recruits Krev interaction trapped protein 1 (KRIT1) to endothelial junctions to…”
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Astrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation
Published in The Journal of clinical investigation (01-07-2021)“…Cerebral cavernous malformations (CCMs) are common neurovascular lesions caused by loss-of-function mutations in 1 of 3 genes, including KRIT1 (CCM1), CCM2,…”
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Isolation and Purification of Mouse Brain Endothelial Cells to Study Cerebral Cavernous Malformation Disease
Published in Methods in molecular biology (Clifton, N.J.) (2020)“…We describe a method to purify primary brain microvascular endothelial cells (BMEC) from mice bearing floxed alleles of Krit1 (Krit1 ) or Pdcd10 (Pdcd10 ) and…”
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Mild Hypoxia Accelerates Cerebral Cavernous Malformation Disease Through CX3CR1-CX3CL1 Signaling
Published in Arteriosclerosis, thrombosis, and vascular biology (01-06-2024)“…Heterogeneity in the severity of cerebral cavernous malformations (CCMs) disease, including brain bleedings and thrombosis that cause neurological disabilities…”
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Astrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation
Published in The Journal of clinical investigation (01-07-2021)“…Cerebral cavernous malformations (CCMs) are common neurovascular lesions caused by loss-of-function mutations in 1 of 3 genes, including KRITI (CCM1), CCM2,…”
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Journal Article -
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Selective service in World War II
Published in Electrical engineering (New York, N.Y.) (01-11-1945)“…A brief summary of the organization and accomplishments of the Selective Service System in World War II which registered and classified more than 45,000,000…”
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