Search Results - "Hale, Laura"

Deficiency of activation-induced cytidine deaminase in a murine model of ulcerative colitis by Hale, Laura P

“…Patients with inflammatory bowel disease (IBD) have an increased risk of colorectal cancer, particularly in ulcerative colitis (UC) when the majority of colon…”
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The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function by Macintyre, Andrew N., Gerriets, Valerie A., Nichols, Amanda G., Michalek, Ryan D., Rudolph, Michael C., Deoliveira, Divino, Anderson, Steven M., Abel, E. Dale, Chen, Benny J., Hale, Laura P., Rathmell, Jeffrey C.

“…CD4 T cell activation leads to proliferation and differentiation into effector (Teff) or regulatory (Treg) cells that mediate or control immunity. While each…”
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Histopathologic assessment of cultured human thymus by Hale, Laura P, Neff, Jadee, Cheatham, Lynn, Cardona, Diana, Markert, M Louise, Kurtzberg, Joanne

“…The maintenance and propagation of complex mixtures of cells in vitro in the form of native organs or engineered organoids has contributed to understanding…”
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Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation by Gerriets, Valerie A, Kishton, Rigel J, Nichols, Amanda G, Macintyre, Andrew N, Inoue, Makoto, Ilkayeva, Olga, Winter, Peter S, Liu, Xiaojing, Priyadharshini, Bhavana, Slawinska, Marta E, Haeberli, Lea, Huck, Catherine, Turka, Laurence A, Wood, Kris C, Hale, Laura P, Smith, Paul A, Schneider, Martin A, MacIver, Nancie J, Locasale, Jason W, Newgard, Christopher B, Shinohara, Mari L, Rathmell, Jeffrey C

“…Activation of CD4+ T cells results in rapid proliferation and differentiation into effector and regulatory subsets. CD4+ effector T cell (Teff) (Th1 and Th17)…”
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Recombination, admixture and genome instability shape the genomic landscape of Saccharomyces cerevisiae derived from spontaneous grape ferments by Ward, Chris M, Onetto, Cristobal A, Van Den Heuvel, Steven, Cuijvers, Kathleen M, Hale, Laura J, Borneman, Anthony R

“…Cultural exchange of fermentation techniques has driven the spread of Saccharomyces cerevisiae across the globe, establishing natural populations in many…”
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Spatial Organization and Composition of the Mucosal Flora in Patients with Inflammatory Bowel Disease by Swidsinski, Alexander, Weber, Jutta, Loening-Baucke, Vera, Hale, Laura P, Lochs, Herbert

“…The composition and spatial organization of the mucosal flora in biopsy specimens from patients with inflammatory bowel disease (IBD; either Crohn's disease or…”
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Late effects of total body irradiation on hematopoietic recovery and immune function in rhesus macaques by Hale, Laura P, Rajam, Gowrisankar, Carlone, George M, Jiang, Chen, Owzar, Kouros, Dugan, Greg, Caudell, David, Chao, Nelson, Cline, J Mark, Register, Thomas C, Sempowski, Gregory D

“…While exposure to radiation can be lifesaving in certain settings, it can also potentially result in long-lasting adverse effects, particularly to…”
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Optimization of Single- and Dual-Color Immunofluorescence Protocols for Formalin-Fixed, Paraffin-Embedded Archival Tissues by Kajimura, Junko, Ito, Reiko, Manley, Nancy R., Hale, Laura P.

“…Performance of immunofluorescence staining on archival formalin-fixed paraffin-embedded human tissues is generally not considered to be feasible, primarily due…”
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Recombinant BCG Expressing Mycobacterium ulcerans Ag85A Imparts Enhanced Protection against Experimental Buruli ulcer by Hart, Bryan E, Hale, Laura P, Lee, Sunhee

“…Buruli ulcer, an emerging tropical disease caused by Mycobacterium ulcerans (MU), is characterized by disfiguring skin necrosis and high morbidity. Relatively…”
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A novel murine model of inflammatory bowel disease and inflammation-associated colon cancer with ulcerative colitis-like features by Hale, Laura P, Greer, Paula K

“…Mutations that increase susceptibility to inflammatory bowel disease (IBD) have been identified in a number of genes in both humans and mice, but the factors…”
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Inflammatory Th1 and Th17 in the Intestine Are Each Driven by Functionally Specialized Dendritic Cells with Distinct Requirements for MyD88 by Liang, Jie, Huang, Hsin-I, Benzatti, Fernanda P., Karlsson, Amelia B., Zhang, Junyi J., Youssef, Nourhan, Ma, Averil, Hale, Laura P., Hammer, Gianna E.

“…Normal dynamics between microbiota and dendritic cells (DCs) support modest numbers of T cells, yet these do not cause inflammation. The DCs that induce…”
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A microfluidic system for studying the behavior of zebrafish larvae under acute hypoxia by Erickstad, Michael, Hale, Laura A, Chalasani, Sreekanth H, Groisman, Alex

“…Oxygen is essential for metabolism of animals and is a vital component of their natural habitats. Hypoxic conditions in tissue, when oxygen levels are lower…”
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Age-Related Changes in Thymic Central Tolerance by Srinivasan, Jayashree, Lancaster, Jessica N, Singarapu, Nandini, Hale, Laura P, Ehrlich, Lauren I R, Richie, Ellen R

“…Thymic epithelial cells (TECs) and hematopoietic antigen presenting cells (HAPCs) in the thymus microenvironment provide essential signals to self-reactive…”
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Bacterial-mucosal interactions in inflammatory bowel disease: an alliance gone bad by Chichlowski, Maciej, Hale, Laura P

“…The complex interaction of genetic, microbial, and environmental factors may result in continuous activation of the mucosal immune system leading to…”
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Role of mast cells in inflammatory bowel disease and inflammation-associated colorectal neoplasia in IL-10-deficient mice by Chichlowski, Maciej, Westwood, Greg S, Abraham, Soman N, Hale, Laura P

“…Inflammatory bowel disease (IBD) is hypothesized to result from stimulation of immune responses against resident intestinal bacteria within a genetically…”
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Irgm1 regulates metabolism and function in T cell subsets by Alwarawrah, Yazan, Danzaki, Keiko, Nichols, Amanda G., Fee, Brian E., Bock, Cheryl, Kucera, Gary, Hale, Laura P., Taylor, Gregory A., MacIver, Nancie J.

“…Immunity Related GTPases (IRG) are a family of proteins produced during infection that regulate membrane remodeling events in cells, particularly autophagy and…”
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Targeting T-cell oxidative metabolism to improve influenza survival in a mouse model of obesity by Alwarawrah, Yazan, Nichols, Amanda G., Green, William D., Eisner, William, Kiernan, Kaitlin, Warren, Jonathan, Hale, Laura P., Beck, Melinda A., MacIver, Nancie J.

“…Background Obesity is associated with impaired primary and secondary immune responses to influenza infection, with T cells playing a critical role. T-cell…”
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CCR4 and CCR7 differentially regulate thymocyte localization with distinct outcomes for central tolerance by Li, Yu, Guaman Tipan, Pablo, Selden, Hilary J, Srinivasan, Jayashree, Hale, Laura P, Ehrlich, Lauren I R

“…Central tolerance ensures autoreactive T cells are eliminated or diverted to the regulatory T cell lineage, thus preventing autoimmunity. To undergo central…”
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Spatial organization of bacterial flora in normal and inflamed intestine： A fluorescence in situ hybridization study in mice by Swidsinski, Alexander, Loening-Baucke, Vera, Lochs, Herbert, Hale, Laura-P

“…AIM: To study the role of intestinal flora in inflammatory bowel disease (IBD). METHODS: The spatial organization of intestinal flora was investigated in…”
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Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: outcome of 44 consecutive transplants by Markert, M. Louise, Devlin, Blythe H., Alexieff, Marilyn J., Li, Jie, McCarthy, Elizabeth A., Gupton, Stephanie E., Chinn, Ivan K., Hale, Laura P., Kepler, Thomas B., He, Min, Sarzotti, Marcella, Skinner, Michael A., Rice, Henry E., Hoehner, Jeffrey C.

“…The purpose of this study was to characterize a large group of infants with complete DiGeorge anomaly and to evaluate the ability of thymus transplantation to…”
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