Search Results - "Haldar, Arun K."

Guanylate binding proteins promote caspase-11–dependent pyroptosis in response to cytoplasmic LPS by Pilla, Danielle M., Hagar, Jon A., Haldar, Arun K., Mason, Ashley K., Degrandi, Daniel, Pfeffer, Klaus, Ernst, Robert K., Yamamoto, Masahiro, Miao, Edward A., Coers, Jörn

“…IFN receptor signaling induces cell-autonomous immunity to infections with intracellular bacterial pathogens. Here, we demonstrate that IFN-inducible guanylate…”
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Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins by Haldar, Arun K., Foltz, Clémence, Finethy, Ryan, Piro, Anthony S., Feeley, Eric M., Pilla-Moffett, Danielle M., Komatsu, Masaki, Frickel, Eva-Maria, Coers, Jörn

“…Many microbes create and maintain pathogen-containing vacuoles (PVs) as an intracellular niche permissive for microbial growth and survival. The destruction of…”
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Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins by Finethy, Ryan, Luoma, Sarah, Orench-Rivera, Nichole, Feeley, Eric M, Haldar, Arun K, Yamamoto, Masahiro, Kanneganti, Thirumala-Devi, Kuehn, Meta J, Coers, Jörn

“…The Gram-negative bacterial cell wall component lipopolysaccharide (LPS) is recognized by the noncanonical inflammasome protein caspase-11 in the cytosol of…”
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IRG and GBP host resistance factors target aberrant, "non-self" vacuoles characterized by the missing of "self" IRGM proteins by Haldar, Arun K, Saka, Hector A, Piro, Anthony S, Dunn, Joe Dan, Henry, Stanley C, Taylor, Gregory A, Frickel, Eva M, Valdivia, Raphael H, Coers, Jörn

“…Interferon-inducible GTPases of the Immunity Related GTPase (IRG) and Guanylate Binding Protein (GBP) families provide resistance to intracellular pathogenic…”
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Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages by Finethy, Ryan, Jorgensen, Ine, Haldar, Arun K, de Zoete, Marcel R, Strowig, Till, Flavell, Richard A, Yamamoto, Masahiro, Nagarajan, Uma M, Miao, Edward A, Coers, Jörn

“…Interferon (IFN)-inducible guanylate binding proteins (GBPs) mediate cell-autonomous host resistance to bacterial pathogens and promote inflammasome…”
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The E2-like conjugation enzyme Atg3 promotes binding of IRG and Gbp proteins to Chlamydia- and Toxoplasma-containing vacuoles and host resistance by Haldar, Arun K, Piro, Anthony S, Pilla, Danielle M, Yamamoto, Masahiro, Coers, Jörn

“…Cell-autonomous immunity to the bacterial pathogen Chlamydia trachomatis and the protozoan pathogen Toxoplasma gondii is controlled by two families of…”
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Chlamydia trachomatis Is Resistant to Inclusion Ubiquitination and Associated Host Defense in Gamma Interferon-Primed Human Epithelial Cells by Haldar, Arun K, Piro, Anthony S, Finethy, Ryan, Espenschied, Scott T, Brown, Hannah E, Giebel, Amanda M, Frickel, Eva-Maria, Nelson, David E, Coers, Jörn

“…The cytokine gamma interferon (IFN-γ) induces cell-autonomous immunity to combat infections with intracellular pathogens, such as the bacterium Chlamydia…”
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Dynamin‐related Irgm proteins modulate LPS‐induced caspase‐11 activation and septic shock by Finethy, Ryan, Dockterman, Jacob, Kutsch, Miriam, Orench‐Rivera, Nichole, Wallace, Graham D, Piro, Anthony S, Luoma, Sarah, Haldar, Arun K, Hwang, Seungmin, Martinez, Jennifer, Kuehn, Meta J, Taylor, Gregory A, Coers, Jörn

“…Inflammation associated with gram‐negative bacterial infections is often instigated by the bacterial cell wall component lipopolysaccharide (LPS). LPS‐induced…”
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Ubiquitination of pathogen-containing vacuoles promotes host defense to Chlamydia trachomatis and Toxoplasma gondii by Coers, Jörn, Haldar, Arun K

“…Many intracellular bacterial and protozoan pathogens reside within host cell vacuoles customized by the microbial invaders to fit their needs. Within such…”
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IRG and GBP Host Resistance Factors Target Aberrant, "Non-self" Vacuoles Characterized by the Missing of "Self" IRGM Proteins: e1003414 by Haldar, Arun K, Saka, Hector A, Piro, Anthony S, Dunn, Joe Dan, Henry, Stanley C, Taylor, Gregory A, Frickel, Eva M, Valdivia, Raphael H, Coers, Jörn

“…Interferon-inducible GTPases of the Immunity Related GTPase (IRG) and Guanylate Binding Protein (GBP) families provide resistance to intracellular pathogenic…”
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The E2-Like Conjugation Enzyme Atg3 Promotes Binding of IRG and Gbp Proteins to Chlamydia- and Toxoplasma-Containing Vacuoles and Host Resistance: e86684 by Haldar, Arun K, Piro, Anthony S, Pilla, Danielle M, Yamamoto, Masahiro, Coers, Jorn

“…Cell-autonomous immunity to the bacterial pathogen Chlamydia trachomatis and the protozoan pathogen Toxoplasma gondii is controlled by two families of…”
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