Search Results - "Halczenko, W"

Surveillance strategies and impact of vancomycin-resistant enterococcal colonization and infection in critically ill patients by Hendrix, C W, Hammond, J M, Swoboda, S M, Merz, W G, Harrington, S M, Perl, T M, Dick, J D, Borschel, D M, Halczenko, P W, Pelz, R K, Rocco, L E, Conway, J E, Brower, R G, Lipsett, P A

“…To determine the optimal site and frequency for vancomycin-resistant enterococci (VRE) surveillance to minimize the number of days of VRE colonization before…”
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Nonpeptide glycoprotein IIb/IIIa inhibitors. 5. Antithrombotic effects of MK-0383 by Lynch, Jr, J J, Cook, J J, Sitko, G R, Holahan, M A, Ramjit, D R, Mellott, M J, Stranieri, M T, Stabilito, I I, Zhang, G, Lynch, R J

“…The antiaggregatory and antithrombotic actions of MK-0383, a low molecular weight, nonpeptide antagonist of the platelet glycoprotein IIb/IIIa, were evaluated…”
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Inhibition of a Mitotic Motor Protein: Where, How, and Conformational Consequences by Yan, Youwei, Sardana, Vinod, Xu, Bei, Homnick, Carl, Halczenko, Wasyl, Buser, Carolyn A., Schaber, Michael, Hartman, George D., Huber, Hans E., Kuo, Lawrence C.

“…We report here the first inhibitor-bound structure of a mitotic motor protein. The 1.9 Å resolution structure of the motor domain of KSP, bound with the small…”
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Non-Peptide Fibrinogen Receptor Antagonists. 2. Optimization of a Tyrosine Template as a Mimic for Arg-Gly-Asp by Egbertson, Melissa S, Chang, Charles T.-C, Duggan, Mark E, Gould, Robert J, Halczenko, Wasyl, Hartman, George D, Laswell, William L, Lynch, Joseph J, Lynch, Robert J

“…Inhibitors of platelet-fibrinogen binding offer an opportunity to interrupt the final, common pathway for platelet aggregation. Small molecule inhibitors of…”
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Non-Peptide Glycoprotein IIb/IIIa Antagonists. 11. Design and in Vivo Evaluation of 3,4-Dihydro-1(1H)-isoquinolinone-Based Antagonists and Ethyl Ester Prodrugs by Hutchinson, John H, Cook, Jacquelynn J, Brashear, Karen M, Breslin, Michael J, Glass, Joan D, Gould, Robert J, Halczenko, Wasyl, Holahan, Marie A, Lynch, Robert J, Sitko, Gary R, Stranieri, Maria T, Hartman, George D

“…The structure−activity relationship of a series of orally active glycoprotein IIb/IIIa antagonists containing a nitrogen heterocycle grafted onto a…”
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Disposition of a novel and potent alpha(v)beta3 antagonist in animals, and extrapolation to man by Prueksaritanont, T, Fernandez-Metzler, C, Meng, Y, Barrish, A, Halczenko, W, Rodan, S B, Hutchinson, J H, Duggan, M E, Lin, J H

“…1. The disposition of 3-[2-oxo-3-[3-(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl) propyl]-imidazolidin-1-yl]-3(S)-(6-methoxy-pyridin-3-yl)propionic acid…”
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Disposition of a novel and potent α v β 3 antagonist in animals, and extrapolation to man by Prueksaritanont, T., Fernandez-Metzler, C., Meng, Y., Barrish, A., Halczenko, W., Rodan, S. B., Hutchinson, J. H., Duggan, M. E., Lin, J. H.

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Disposition of a novel and potent αvβ3 antagonist in animals, and extrapolation to man by Prueksaritanont, T., Fernandez-Metzler, C., Meng, Y., Barrish, A., Halczenko, W., Rodan, S. B., Hutchinson, J. H., Duggan, M. E., Lin, J. H.

“…1. The disposition of 3-{2-oxo-3-[3-(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl) propyl]-imidazolidin-1-yl}-3(S)-(6-methoxy-pyridin-3-yl)propionic acid…”
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Disposition of a novel and potent α v β 3 antagonist in animals, and extrapolation to man by Prueksaritanont, T., Fernandez-Metzler, C., Meng, Y., Barrish, A., Halczenko, W., Rodan, S. B., Hutchinson, J. H., Duggan, M. E., Lin, J. H.

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Disposition of a novel and potent f sub(v)g sub(3) antagonist in animals, and extrapolation to man by Prueksaritanont, T, Fernandez-Metzler, C, Meng, Y, Barrish, A, Halczenko, W, Rodan, S B, Hutchinson, J H, Duggan, ME, Lin, J H

“…The disposition of 3-{2-oxo-3-[3-(5,6,7,8-tetrahydro-[1,8] naphthyridin-2-yl) propyl]-imidazolidin-1-yl}-3(S)-(6-methoxypyridin-3-yl)propionic acid (compound…”
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Nonpeptide glycoprotein IIb/IIIa inhibitors: 18. Indole alpha-sulfonamide acids are potent inhibitors of platelet aggregation by Brashear, Karen M., Cook, Jacquelynn J., Bednar, Bohumil, Bednar, Rodney A., Gould, Robert J., Halczenko, Wasyl, Holahan, Marie A., Lynch, Robert J., Hartman, George D., Hutchinson, John.H.

“…The structure-activity relationship (SAR) of a series of orally active glycoprotein IIb/IIIa antagonists containing an alkyl or aryl sulfonamide grafted onto…”
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Nonpeptide GPIIB/IIIA receptor antagonists. Part 21: C-6 flexibility and amide bond orientation are important factors in determining the affinity of compounds for activated or resting platelet receptors by Egbertson, Melissa S, Bednar, Bohumil, Askew, Ben C, Bednar, Rodney A, Brashear, Karen, Breslin, Michael J, Duggan, Mark E, Fisher, Thorsten E, Halczenko, Wasyl, Hutchinson, John H, Ihle, Nathan, Prugh, John D, Wai, John S, Gould, Robert J, Hartman, George D

“…Compound affinity for activated and resting GPIIb/IIIa receptors may differ, and comparison of those differences determines selectivity. Structural features…”
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Nonpeptide glycoprotein IIB/IIIA inhibitors. 12. Potent and orally active centrally constrained thieno[2,3-c]pyridones by Halczenko, Wasyl, Cook, Jacquelynn J., Holahan, Marie A., Sitko, Gary R., Stranieri, Maria T., Zhang, Guixiang, Lynch, Robert J., Lynch, Joseph J., Gould, Robert J., Hartman, George D.

“…A series of potent, orally active thieno[2,3-c]pyridone GPIIb/IIIa inhibitors featuring β-alanine C-2 sulfonamide substitution is described…”
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Imino-bridged heterocycles. I. A derivative of benzo[5,6]cyclohepta[1,2-b]pyridin-5,11-imine by Halczenko, W., Shepard, K. L.

“…The current interest in structures that contain a tricyclic framework with a nitrogen bridged central ring has prompted us to examine the synthesis of…”
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Synthesis and derivatization of novel 4-aroylthiophene-and furan-2-sulfonamides by Hartman, George D., Halczenko, Wasyl

“…Sulfonation of 3‐aroylthiophenes and furans with sulfuric acid in acetic anhydride regioselectively affords the corresponding 2,4‐disubstituted heterocycle…”
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Thieno[2,3-b]furan-2-sulfonamides as topical carbonic anhydrase inhibitors by Hartman, George D, Halczenko, Wasyl, Prugh, John D, Smith, Robert L, Sugrue, Michael F, Mallorga, Pierre, Michelson, Stuart R, Randall, William C, Schwam, Harvey, Sondey, John M

“…Novel 5-[(alkylamino)methyl]thieno[2,3-b]furan-2-sulfonamides were prepared and evaluated in vitro for inhibition of human carbonic anhydrase II (CA II) and ex…”
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4-Substituted thiophene- and furan-2-sulfonamides as topical carbonic anhydrase inhibitors by Hartman, George D, Halczenko, Wasyl, Smith, Robert L, Sugrue, Michael F, Mallorga, Pierre J, Michelson, Stuart R, Randall, William C, Schwam, Harvey, Sondey, John M

“…A series of 4-substituted thiophene- and furan-2-sulfonamides was prepared and was found to possess nanomolar-level potency for inhibition of human carbonic…”
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Thieno(2,3-b)furan-2-sulfonamides as topical carbonic anhydrase inhibitors by Hartman, G D, Halczenko, W, Prugh, J D, Smith, R L, Sugrue, M F, Mallorga, P, Michelson, SR, Randall, W C, Schwam, H, Sondey, J M

“…Novel 5-((alkylamino)methyl)-thieno(2,3-b)furan-2-sulfonamides were prepared and evaluated in vitro for inhibition of human carbonic anhydrase II (CA II) and…”
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Synthesis and derivatization of 4-arylsulfonylthiophene- and furan-2-sulfonamides by Hartman, George D., Halczenko, Wasyl

“…Novel 4‐arylsulfonylthiophene‐ and furan‐2‐sulfonamides are prepared from the 3‐arylsulfonyl heterocycle via chlorosulfonation with chlorosulfonic…”
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Non-peptide fibrinogen receptor antagonists. II: Optimizatioin of a tyrosine template as a mimic for Arg-Gly-Asp by EGBERTSON, M. S, CHANG, C. T.-C, NAYLOR, A. M, PRUGH, J. D, RAMJIT, D. R, SITKO, G. R, SMITH, R. S, TURCHI, L. M, GUIXIANG ZHANG, DUGGAN, M. E, GOULD, R. J, HALCZENKO, W, HARTMAN, G. D, LASWELL, W. L, LYNCH, J. J, LYNCH, R. J, MANNO, P. D

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