Search Results - "Halby, Ludovic"

triple helix: 50 years later, the outcome by Duca, Maria, Vekhoff, Pierre, Oussedik, Kahina, Halby, Ludovic, Arimondo, Paola B

“…Triplex-forming oligonucleotides constitute an interesting DNA sequence-specific tool that can be used to target cleaving or cross-linking agents,…”
Get full text

DNA Methylation Targeting: The DNMT/HMT Crosstalk Challenge by Castillo-Aguilera, Omar, Depreux, Patrick, Halby, Ludovic, Arimondo, Paola B, Goossens, Laurence

“…Chromatin can adopt a decondensed state linked to gene transcription (euchromatin) and a condensed state linked to transcriptional repression…”
Get full text

Synthesis and Biological Activity of a Cytostatic Inhibitor of MLLr Leukemia Targeting the DOT1L Protein by Bon, Corentin, Si, Yang, Pernak, Melanie, Barbachowska, Magdalena, Levi-Acobas, Eva, Cadet Daniel, Veronique, Jallet, Corinne, Ruzic, Dusan, Djokovic, Nemanja, Djikić, Teodora, Nikolic, Katarina, Halby, Ludovic, Arimondo, Paola B

“…Histone methyltransferase DOT1L catalyzes mono-, di- and trimethylation of histone 3 at lysine residue 79 (H3K79) and hypermethylation of H3K79 has been linked…”
Get full text

Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors by Halby, Ludovic, Marechal, Nils, Pechalrieu, Dany, Cura, Vincent, Franchini, Don-Marc, Faux, Céline, Alby, Fréderic, Troffer-Charlier, Nathalie, Kudithipudi, Srikanth, Jeltsch, Albert, Aouadi, Wahiba, Decroly, Etienne, Guillemot, Jean-Claude, Page, Patrick, Ferroud, Clotilde, Bonnefond, Luc, Guianvarc'h, Dominique, Cavarelli, Jean, Arimondo, Paola B.

“…DNA, RNA and histone methylation is implicated in various human diseases such as cancer or viral infections, playing a major role in cell process regulation,…”
Get full text

Direct Synthesis of Allyl Amines with 2‐Nitrosulfonamide Derivatives via the Tsuji‐Trost Reaction by Bon, Corentin, Arimondo, Paola B., Halby, Ludovic

“…The Tsuji‐Trost Reaction is a palladium‐catalysed allylation of nucleophiles that consists in the reaction of a nitrogen, carbon or oxygen‐based nucleophiles…”
Get full text

DNA Methylation Bisubstrate Inhibitors Are Fast-Acting Drugs Active against Artemisinin-Resistant Plasmodium falciparum Parasites by Nardella, Flore, Halby, Ludovic, Hammam, Elie, Erdmann, Diane, Cadet-Daniel, Véronique, Peronet, Roger, Ménard, Didier, Witkowski, Benoit, Mecheri, Salah, Scherf, Artur, Arimondo, Paola B

“…Malaria is the deadliest parasitic disease affecting over 200 million people worldwide. The increasing number of treatment failures due to multi-drug-resistant…”
Get full text

Hemisynthetic alkaloids derived from trilobine are antimalarials with sustained activity in multidrug-resistant Plasmodium falciparum by Nardella, Flore, Dobrescu, Irina, Hassan, Haitham, Rodrigues, Fabien, Thiberge, Sabine, Mancio-Silva, Liliana, Tafit, Ambre, Jallet, Corinne, Cadet-Daniel, Véronique, Goussin, Stéphane, Lorthiois, Audrey, Menon, Yoann, Molinier, Nicolas, Pechalrieu, Dany, Long, Christophe, Sautel, François, Matondo, Mariette, Duchateau, Magalie, Médard, Guillaume, Witkowski, Benoit, Scherf, Artur, Halby, Ludovic, Arimondo, Paola B.

“…Malaria eradication requires the development of new drugs to combat drug-resistant parasites. We identified bisbenzylisoquinoline alkaloids isolated from…”
Get full text

Sequence-specific targeting of IGF-I and IGF-IR genes by camptothecins by Oussedik, Kahina, François, Jean-Christophe, Halby, Ludovic, Senamaud-Beaufort, Catherine, Toutirais, Géraldine, Dallavalle, Sabrina, Pommier, Yves, Pisano, Claudio, Arimondo, Paola B

“…We and others have clearly demonstrated that a topoisomerase I (Top1) inhibitor, such as camptothecin (CPT), coupled to a triplex-forming oligonucleotide (TFO)…”
Get full text

Optimized Synthesis and Enhanced Efficacy of Novel Triplex-Forming Camptothecin Derivatives Based on Gimatecan by Vekhoff, Pierre, Halby, Ludovic, Oussedik, Kahina, Dallavalle, Sabrina, Merlini, Lucio, Mahieu, Christine, Lansiaux, Amélie, Bailly, Christian, Boutorine, Alexandre, Pisano, Claudio, Giannini, Giuseppe, Alloatti, Domenico, Arimondo, Paola B

“…Sequence-specific camptothecins are useful tools to inhibit specifically gene expression. The camptothecins are attached to the 3′ end of triplex-forming…”
Get full text

Targeting MDR1 gene: synthesis and cellular study of modified daunomycin-triplex-forming oligonucleotide conjugates able to inhibit gene expression in resistant cell lines by Stierlé, Vérène, Duca, Maria, Halby, Ludovic, Senamaud-Beaufort, Catherine, Capobianco, Massimo L, Laigle, Alain, Jollès, Béatrice, Arimondo, Paola B

“…Reversal of the multidrug-resistant (MDR) phenotype is very important for chemotherapy success. In fact, the expression of the MDR1 gene-encoded P-glycoprotein…”
Get more information

Exploring the Cellular Activity of Camptothecin-Triple-Helix-Forming Oligonucleotide Conjugates by Arimondo, Paola B., Thomas, Craig J., Oussedik, Kahina, Baldeyrou, Brigitte, Mahieu, Christine, Halby, Ludovic, Guianvarc'h, Dominique, Lansiaux, Amélie, Hecht, Sidney M., Bailly, Christian, Giovannangeli, Carine

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Targeting DNA Methylation with Small Molecules: What’s Next?: Miniperspective by Erdmann, Alexandre, Halby, Ludovic, Fahy, Jacques, Arimondo, Paola B

“…DNA methylation is a mammalian epigenetic mark that is involved in defining where and when genes are expressed, both in normal cells and in the context of…”
Get full text

Targeting DNA methylation with small molecules: what's next? by Erdmann, Alexandre, Halby, Ludovic, Fahy, Jacques, Arimondo, Paola B

“…DNA methylation is a mammalian epigenetic mark that is involved in defining where and when genes are expressed, both in normal cells and in the context of…”
Get full text

Bisubstrate inhibitors: the promise of a selective and potent chemical inhibition of epigenetic ‘writers’ by Bon, Corentin, Halby, Ludovic, Arimondo, Paola Barbara

Get full text

Editorial : Bisubstrate inhibitors: the promise of a selective and potent chemical inhibition of epigenetic “writers by Bon, Corentin, Halby, Ludovic, Arimondo, Paola B, Arimondo, Paola B

Get full text

Towards the sustainable discovery and development of new antibiotics by Miethke, Marcus, Pieroni, Marco, Weber, Tilmann, Brönstrup, Mark, Hammann, Peter, Halby, Ludovic, Arimondo, Paola B., Glaser, Philippe, Aigle, Bertrand, Bode, Helge B., Moreira, Rui, Li, Yanyan, Luzhetskyy, Andriy, Medema, Marnix H., Pernodet, Jean-Luc, Stadler, Marc, Tormo, José Rubén, Genilloud, Olga, Truman, Andrew W., Weissman, Kira J., Takano, Eriko, Sabatini, Stefano, Stegmann, Evi, Brötz-Oesterhelt, Heike, Wohlleben, Wolfgang, Seemann, Myriam, Empting, Martin, Hirsch, Anna K. H., Loretz, Brigitta, Lehr, Claus-Michael, Titz, Alexander, Herrmann, Jennifer, Jaeger, Timo, Alt, Silke, Hesterkamp, Thomas, Winterhalter, Mathias, Schiefer, Andrea, Pfarr, Kenneth, Hoerauf, Achim, Graz, Heather, Graz, Michael, Lindvall, Mika, Ramurthy, Savithri, Karlén, Anders, van Dongen, Maarten, Petkovic, Hrvoje, Keller, Andreas, Peyrane, Frédéric, Donadio, Stefano, Fraisse, Laurent, Piddock, Laura J. V., Gilbert, Ian H., Moser, Heinz E., Müller, Rolf

“…An ever-increasing demand for novel antimicrobials to treat life-threatening infections caused by the global spread of multidrug-resistant bacterial pathogens…”
Get full text

DNA methylation inhibitors in cancer: Recent and future approaches by Gros, Christina, Fahy, Jacques, Halby, Ludovic, Dufau, Isabelle, Erdmann, Alexandre, Gregoire, Jean-Marc, Ausseil, Fréderic, Vispé, Stéphane, Arimondo, Paola B.

“…This review presents the different human DNA methyltransferases (DNMTs), their biological roles, their mechanisms of action and their role in cancer. The…”
Get full text

Procainamide–SAHA Fused Inhibitors of hHDAC6 Tackle Multidrug-Resistant Malaria Parasites by Nardella, Flore, Halby, Ludovic, Dobrescu, Irina, Viluma, Johanna, Bon, Corentin, Claes, Aurélie, Cadet-Daniel, Véronique, Tafit, Ambre, Roesch, Camille, Hammam, Elie, Erdmann, Diane, Mairet-Khedim, Melissa, Peronet, Roger, Mecheri, Salah, Witkowski, Benoit, Scherf, Artur, Arimondo, Paola B

“…Epigenetic post-translational modifications are essential for human malaria parasite survival and progression through its life cycle. Here, we present new…”
Get full text

Rational Design of Bisubstrate-Type Analogues as Inhibitors of DNA Methyltransferases in Cancer Cells by Halby, Ludovic, Menon, Yoann, Rilova, Elodie, Pechalrieu, Dany, Masson, Véronique, Faux, Celine, Bouhlel, Mohamed Amine, David-Cordonnier, Marie-Hélène, Novosad, Natacha, Aussagues, Yannick, Samson, Arnaud, Lacroix, Laurent, Ausseil, Fréderic, Fleury, Laurence, Guianvarc’h, Dominique, Ferroud, Clotilde, Arimondo, Paola B

“…Aberrant DNA hypermethylation of promoter of tumor suppressor genes is commonly observed in cancer, and its inhibition by small molecules is promising for…”
Get full text

Regioselective and efficient halogenation of 4,5-unsubstituted alkyl 3-hydroxypyrrole/3-hydroxythiophene-2-yl-carboxylates by Castillo-Aguilera, Omar, Depreux, Patrick, Halby, Ludovic, Azaroual, Nathalie, Arimondo, Paola B., Goossens, Laurence

“…Substituted heterocycles, such as pyrrole and thiophene, are commonly found in the field of pharmaceutical and material sciences. Here we studied the…”
Get full text