Search Results - "Halbrooks, Peter J."

The Crystal Structure of Iron-free Human Serum Transferrin Provides Insight into Inter-lobe Communication and Receptor Binding by Wally, Jeremy, Halbrooks, Peter J., Vonrhein, Clemens, Rould, Mark A., Everse, Stephen J., Mason, Anne B., Buchanan, Susan K.

“…Serum transferrin reversibly binds iron in each of two lobes and delivers it to cells by a receptor-mediated, pH-dependent process. The binding and release of…”
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The Oxalate Effect on Release of Iron from Human Serum Transferrin Explained by Halbrooks, Peter J, Mason, Anne B, Adams, Ty E, Briggs, Sara K, Everse, Stephen J

“…A unique feature of the mechanism of iron binding to the transferrin (TF) family is the synergistic relationship between metal binding and anion binding…”
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Investigation of the Mechanism of Iron Release from the C-Lobe of Human Serum Transferrin:  Mutational Analysis of the Role of a pH Sensitive Triad by Halbrooks, Peter J, He, Qing-Yu, Briggs, Sara K, Everse, Stephen J, Smith, Valerie C, MacGillivray, Ross T. A, Mason, Anne B

“…The transferrins (TFs) are a family of proteins that are widely distributed in vertebrates, where they serve a major role in iron binding and transport. Most…”
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Expression, purification, and characterization of authentic monoferric and apo-human serum transferrins by Mason, Anne B., Halbrooks, Peter J., Larouche, Julia R., Briggs, Sara K., Moffett, Marque L., Ramsey, Jon E., Connolly, Susan A., Smith, Valerie C., MacGillivray, Ross T.A.

“…Transferrin is a bilobal protein with the ability to bind iron in two binding sites situated at the bottom of a cleft in each lobe. We have previously…”
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Evolution of the transferrin family: Conservation of residues associated with iron and anion binding by Lambert, Lisa A., Perri, Holly, Halbrooks, Peter J., Mason, Anne B.

“…The transferrin family spans both vertebrates and invertebrates. It includes serum transferrin, ovotransferrin, lactoferrin, melanotransferrin, inhibitor of…”
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Role of RGM coreceptors in bone morphogenetic protein signaling by Halbrooks, Peter J, Ding, Ru, Wozney, John M, Bain, Gerard

“…The repulsive guidance molecule (RGM) proteins, originally discovered for their roles in neuronal development, have been recently identified as co-receptors in…”
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The Molecular Mechanism for Receptor-Stimulated Iron Release from the Plasma Iron Transport Protein Transferrin by Giannetti, Anthony M., Halbrooks, Peter J., Mason, Anne B., Vogt, Todd M., Enns, Caroline A., Björkman, Pamela J.

“…Human transferrin receptor 1 (TfR) binds iron-loaded transferrin (Fe-Tf) and transports it to acidic endosomes where iron is released in a TfR-facilitated…”
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Mutational Analysis of C-Lobe Ligands of Human Serum Transferrin:  Insights into the Mechanism of Iron Release by Mason, Anne B, Halbrooks, Peter J, James, Nicholas G, Connolly, Susan A, Larouche, Julia R, Smith, Valerie C, MacGillivray, Ross T. A, Chasteen, N. Dennis

“…Each homologous lobe of human serum transferrin (hTF) has one Fe3+ ion bound by an aspartic acid, a histidine, two tyrosine residues, and two oxygens from the…”
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Structural and Functional Consequences of the Substitution of Glycine 65 with Arginine in the N-Lobe of Human Transferrin by Mason, Anne B, Halbrooks, Peter J, James, Nicholas G, Byrne, Shaina L, Grady, John K, Chasteen, N. Dennis, Bobst, Cedric E, Kaltashov, Igor A, Smith, Valerie C, MacGillivray, Ross T. A, Everse, Stephen J

“…The G65R mutation in the N-lobe of human transferrin was created to mimic a naturally occurring variant (G394R) found in the homologous C-lobe. Because Gly65…”
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The position of arginine 124 controls the rate of iron release from the N-lobe of human serum transferrin. A structural study by Adams, Ty E, Mason, Anne B, He, Qing-Yu, Halbrooks, Peter J, Briggs, Sara K, Smith, Valerie C, MacGillivray, Ross T A, Everse, Stephen J

“…Human serum transferrin (hTF) is a bilobal iron-binding and transport protein that carries iron in the blood stream for delivery to cells by a pH-dependent…”
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Composition of pH-Sensitive Triad in C-Lobe of Human Serum Transferrin. Comparison to Sequences of Ovotransferrin and Lactoferrin Provides Insight into Functional Differences in Iron Release by Halbrooks, Peter J., Giannetti, Anthony M., Klein, Joshua S., Björkman, Pamela J., Larouche, Julia R., Smith, Valerie C., MacGillivray, Ross T. A., Everse, Stephen J., Mason, Anne B.

“…The transferrins (TF) are a family of bilobal glycoproteins that tightly bind ferric iron. Each of the homologous N- and C-lobes contains a single iron-binding…”
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Structural and functional consequences of the substitution of glycine 65 by arginine in the N-lobe of human transferrin by Mason, Anne B., Halbrooks, Peter J., James, Nicholas G., Byrne, Shaina L., Grady, John K., Chasteen, N. Dennis, Bobst, Cedric E., Kaltashov, Igor A., Smith, Valerie C., MacGillivray, Ross T. A., Everse, Stephen J.

“…The G65R mutation in the N-lobe of human transferrin was created to mimic a naturally occurring variant (G394R) found in the homologous C-lobe. Because Gly65…”
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Differential Effect of a His Tag at the N- and C-Termini:  Functional Studies with Recombinant Human Serum Transferrin by Mason, Anne B, He, Qing-Yu, Halbrooks, Peter J, Everse, Stephen J, Gumerov, Dmitry R, Kaltashov, Igor A, Smith, Valerie C, Hewitt, Jeff, MacGillivray, Ross T. A

“…Attachment of a cleavable hexa His tag is a common strategy for the production of recombinant proteins. Production of two recombinant nonglycosylated human…”
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The Position of Arginine 124 Controls the Rate of Iron Release from the N-lobe of Human Serum Transferrin by Adams, Ty E., Mason, Anne B., He, Qing-Yu, Halbrooks, Peter J., Briggs, Sara K., Smith, Valerie C., MacGillivray, Ross T.A., Everse, Stephen J.

“…Human serum transferrin (hTF) is a bilobal iron-binding and transport protein that carries iron in the blood stream for delivery to cells by a pH-dependent…”
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