Search Results - "Halbert, Jean"
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1
Repurposing of promoters and enhancers during mammalian evolution
Published in Nature communications (04-10-2018)“…Promoters and enhancers—key controllers of gene expression—have long been distinguished from each other based on their function. However, recent work suggested…”
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2
Expression in Yeast Links Field Polymorphisms in PfATP6 to in Vitro Artemisinin Resistance and Identifies New Inhibitor Classes
Published in The Journal of infectious diseases (01-08-2013)“…Background. The mechanism of action of artemisinins against malaria is unclear, despite their widespread use in combination therapies and the emergence of…”
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3
Host genotype by parasite genotype interactions underlying the resistance of anopheline mosquitoes to Plasmodium falciparum
Published in Malaria journal (11-01-2005)“…Most studies on the resistance of mosquitoes to their malaria parasites focus on the response of a mosquito line or colony against a single parasite genotype…”
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A Plasmodium falciparum Transcriptional Cyclin-Dependent Kinase-Related Kinase with a Crucial Role in Parasite Proliferation Associates with Histone Deacetylase Activity
Published in Eukaryotic Cell (01-06-2010)“…OA Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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5
Gene expression across mammalian organ development
Published in Nature (London) (01-07-2019)“…The evolution of gene expression in mammalian organ development remains largely uncharacterized. Here we report the transcriptomes of seven organs (cerebrum,…”
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6
Conserved microRNA editing in mammalian evolution, development and disease
Published in Genome biology (25-06-2014)“…Mammalian microRNAs (miRNAs) are sometimes subject to adenosine-to-inosine RNA editing, which can lead to dramatic changes in miRNA target specificity or…”
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Sex-biased microRNA expression in mammals and birds reveals underlying regulatory mechanisms and a role in dosage compensation
Published in Genome research (01-12-2017)“…Sexual dimorphism depends on sex-biased gene expression, but the contributions of microRNAs (miRNAs) have not been globally assessed. We therefore produced an…”
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8
Regulation of Plasmodium falciparum Development by Calcium-dependent Protein Kinase 7 (PfCDPK7)
Published in The Journal of biological chemistry (18-07-2014)“…Second messengers such as phosphoinositides and calcium are known to control diverse processes involved in the development of malaria parasites. However, the…”
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9
Convergent origination of a Drosophila -like dosage compensation mechanism in a reptile lineage
Published in Genome research (01-12-2017)“…Sex chromosomes differentiated from different ancestral autosomes in various vertebrate lineages. Here, we trace the functional evolution of the XY Chromosomes…”
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Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum
Published in Nature communications (29-11-2011)“…The role of protein phosphorylation in the life cycle of malaria parasites is slowly emerging. Here we combine global phospho-proteomic analysis with…”
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11
Expression Evolution of Ancestral XY Gametologs across All Major Groups of Placental Mammals
Published in Genome biology and evolution (03-11-2020)“…Abstract Placental mammals present 180 million-year-old Y chromosomes that have retained a handful of dosage-sensitive genes. However, the expression evolution…”
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Two nucleus-localized CDK-like kinases with crucial roles for malaria parasite erythrocytic replication are involved in phosphorylation of splicing factor
Published in Journal of cellular biochemistry (01-05-2011)“…The kinome of the human malaria parasite Plasmodium falciparum comprises representatives of most eukaryotic protein kinase groups, including kinases which…”
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Functional characterization of both MAP kinases of the human malaria parasite Plasmodium falciparum by reverse genetics
Published in Molecular microbiology (01-09-2007)“…Summary The kinome of the human malaria parasite Plasmodium falciparum includes two genes encoding mitogen‐activated protein kinase (MAPK) homologues, pfmap‐1…”
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14
Malaria: Targeting parasite and host cell kinomes
Published in Biochimica et biophysica acta (01-03-2010)“…Malaria still remains one of the deadliest infectious diseases, and has a tremendous morbidity and mortality impact in the developing world. The propensity of…”
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Weaving webs of ownership: Intellectual property in an information age
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Dissertation -
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Weaving webs of ownership: Intellectual property in an information age
Published 01-01-1996“…Copyright emerged in its present legal form in 18th century England. As technology advanced, the law was used to incorporate more types of creative work and…”
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Dissertation