Search Results - "Halbert, Gavin"

Mefenamic acid solid dispersions: Impact of formulation composition on processing parameters, product properties and performance by Prasad, Elke, Robertson, John, Halbert, Gavin W.

“…[Display omitted] The objective of this study was to develop an immediate release (IR), crystalline solid dispersion (CSD) formulation of Mefenamic acid (MFA)…”
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Manufacturing Considerations for the Development of Lipid Nanoparticles Using Microfluidics by Roces, Carla B, Lou, Gustavo, Jain, Nikita, Abraham, Suraj, Thomas, Anitha, Halbert, Gavin W, Perrie, Yvonne

“…In the recent of years, the use of lipid nanoparticles (LNPs) for RNA delivery has gained considerable attention, with a large number in the clinical pipeline…”
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Characterisation of colloidal structures and their solubilising potential for BCS class II drugs in fasted state simulated intestinal fluid by McKinnon, Zoe, Khadra, Ibrahim, Halbert, Gavin W., Batchelor, Hannah K.

“…[Display omitted] A suite of fasted state simulated intestinal fluid (SIF), based on variability observed in a range of fasted state human intestinal fluid…”
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Improving Consistency for a Mefenamic Acid Immediate Release Formulation by Prasad, Elke, Robertson, John, Halbert, Gavin W

“…The objective of this study was to develop an immediate release dose form containing 250 mg Mefenamic acid (MFA) presented as a crystalline solid dispersion in…”
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Structured solubility behaviour in fed simulated intestinal fluids by Silva, Maria Inês, Khadra, Ibrahim, Pyper, Kate, Halbert, Gavin W

“…Intestinal drug solubility is a key parameter controlling absorption after the administration of a solid oral dosage form. The ability to measure fed state…”
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Fed intestinal solubility limits and distributions applied to the Developability classification system by Silva, Maria Inês, Khadra, Ibrahim, Pyper, Kate, Halbert, Gavin W.

“…[Display omitted] For solid oral dosage forms drug solubility in intestinal fluid is an important parameter influencing product performance and…”
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Fasted intestinal solubility limits and distributions applied to the biopharmaceutics and developability classification systems by Abuhassan, Qamar, Khadra, Ibrahim, Pyper, Kate, Augustijns, Patrick, Brouwers, Joachim, Halbert, Gavin W.

“…[Display omitted] After oral administration, a drug’s solubility in intestinal fluid is an important parameter influencing bioavailability and if the value is…”
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Structured solubility behaviour in bioequivalent fasted simulated intestinal fluids by Abuhassan, Qamar, Khadra, Ibrahim, Pyper, Kate, Augustijns, Patrick, Brouwers, Joachim, Halbert, Gavin W.

“…[Display omitted] Drug solubility in intestinal fluid is a key parameter controlling absorption after the administration of a solid oral dosage form. To…”
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Small scale in vitro method to determine a bioequivalent equilibrium solubility range for fasted human intestinal fluid by Abuhassan, Qamar, Khadra, Ibrahim, Pyper, Kate, Halbert, Gavin W.

“…[Display omitted] Drug solubility is a key parameter controlling oral absorption, but intestinal solubility is difficult to assess in vitro. Human intestinal…”
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Small scale in vitro method to determine a potential bioequivalent equilibrium solubility range for fed human intestinal fluid by Inês Silva, Maria, Khadra, Ibrahim, Pyper, Kate, Halbert, Gavin W.

“…[Display omitted] Intestinal drug solubility is a key parameter controlling oral absorption but varies both intra and inter individuals and between the fasted…”
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An Additive Manufacturing MicroFactory: Overcoming Brittle Material Failure and Improving Product Performance through Tablet Micro-Structure Control for an Immediate Release Dose Form by Prasad, Elke, Robertson, John, Halbert, Gavin W

“…Additive manufacturing of pharmaceutical formulations offers advanced micro-structure control of oral solid dose (OSD) forms targeting not only customised…”
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Rapid scale-up and production of active-loaded PEGylated liposomes by Roces, Carla B., Port, Emily Charlotte, Daskalakis, Nikolaos N., Watts, Julie A., Aylott, Jonathan W., Halbert, Gavin W., Perrie, Yvonne

“…[Display omitted] Manufacturing of liposomal nanomedicines (e.g. Doxil®/Caelyx®) is a challenging and slow process based on multiple-vessel and batch…”
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Statistical investigation of simulated fed intestinal media composition on the equilibrium solubility of oral drugs by Zhou, Zhou, Dunn, Claire, Khadra, Ibrahim, Wilson, Clive G., Halbert, Gavin W.

“…Gastrointestinal fluid is a complex milieu and it is recognised that gut drug solubility is different to that observed in simple aqueous buffers. Simulated…”
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A novel hot-melt extrusion formulation of albendazole for increasing dissolution properties by Martinez-Marcos, Laura, Lamprou, Dimitrios A., McBurney, Roy T., Halbert, Gavin W.

“…[Display omitted] The main aim of the research focused on the production of hot-melt extrusion (HME) formulations with increased dissolution properties of…”
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Topography of Simulated Intestinal Equilibrium Solubility by Dunn, Claire, Perrier, Jeremy, Khadra, Ibrahim, Wilson, Clive G, Halbert, Gavin W

“…Oral administration of a solid dosage form requires drug dissolution in the gastrointestinal tract before absorption. Solubility is a key factor controlling…”
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A novel simulated media system for in vitro evaluation of bioequivalent intestinal drug solubility by Abuhassan, Qamar, Silva, Maria Inês, Tamimi, Rana Abu-Rajab, Khadra, Ibrahim, Batchelor, Hannah K., Pyper, Kate, Halbert, Gavin W.

“…[Display omitted] Orally administered solid drug must dissolve in the gastrointestinal tract before absorption to provide a systemic response. Intestinal…”
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Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs by Bergström, Christel A.S., Holm, René, Jørgensen, Søren Astrup, Andersson, Sara B.E., Artursson, Per, Beato, Stefania, Borde, Anders, Box, Karl, Brewster, Marcus, Dressman, Jennifer, Feng, Kung-I., Halbert, Gavin, Kostewicz, Edmund, McAllister, Mark, Muenster, Uwe, Thinnes, Julian, Taylor, Robert, Mullertz, Anette

“…Preformulation measurements are used to estimate the fraction absorbed in vivo for orally administered compounds and thereby allow an early evaluation of the…”
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Influence of Physiological Gastrointestinal Surfactant Ratio on the Equilibrium Solubility of BCS Class II Drugs Investigated Using a Four Component Mixture Design by Zhou, Zhou, Dunn, Claire, Khadra, Ibrahim, Wilson, Clive G, Halbert, Gavin W

“…The absorption of poorly water-soluble drugs is influenced by the luminal gastrointestinal fluid content and composition, which control solubility. Simulated…”
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Use of Terahertz-Raman Spectroscopy to Determine Solubility of the Crystalline Active Pharmaceutical Ingredient in Polymeric Matrices during Hot Melt Extrusion by Bordos, Ecaterina, Islam, Muhammad T, Florence, Alastair J, Halbert, Gavin W, Robertson, John

“…Polymer-based amorphous solid dispersions (ASDs) comprise one of the most promising formulation strategies devised to improve the oral bioavailability of…”
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Excipient Impact on Fenofibrate Equilibrium Solubility in Fasted and Fed Simulated Intestinal Fluids Assessed Using a Design of Experiment Protocol by Ainousah, Bayan E, Khadra, Ibrahim, Halbert, Gavin W

“…Solubility is a critical parameter controlling drug absorption after oral administration. For poorly soluble drugs, solubility is influenced by the complex…”
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