Search Results - "Halban, P. A."

Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications by DONATH, M. Y, HALBAN, P. A

“…Increasing evidence indicates that decreased functional beta-cell mass is the hallmark of both Type 1 and Type 2 diabetes. This underlies the absolute or…”
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Proliferation of sorted human and rat beta cells by Parnaud, G, Bosco, D, Berney, T, Pattou, F, Kerr-Conte, J, Donath, M. Y, Bruun, C, Mandrup-Poulsen, T, Billestrup, N, Halban, P. A

“…Aims/hypothesis The aim of the study was to determine whether purified beta cells can replicate in vitro and whether this is enhanced by extracellular matrix…”
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Non-muscle myosin IIA is involved in focal adhesion and actin remodelling controlling glucose-stimulated insulin secretion by Arous, C., Rondas, D., Halban, P. A.

“…Aims/hypothesis Actin and focal adhesion (FA) remodelling are essential for glucose-stimulated insulin secretion (GSIS). Non-muscle myosin II (NM II) isoforms…”
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Cardiotrophin 1 protects beta cells from apoptosis and prevents streptozotocin-induced diabetes in a mouse model by Jiménez-González, M., Jaques, F., Rodríguez, S., Porciuncula, A., Principe, R. M., Abizanda, G., Iñiguez, M., Escalada, J., Salvador, J., Prósper, F., Halban, P. A., Barajas, M.

“…Aims/hypothesis Cardiotrophin 1 (CT-1) is a recently described cytokine originally isolated from the heart where it has been shown to play an important role in…”
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Pioglitazone and Sodium Salicylate Protect Human β-Cells against Apoptosis and Impaired Function Induced by Glucose and Interleukin-1β by Zeender, E., Maedler, K., Bosco, D., Berney, T., Donath, M. Y., Halban, P. A.

“…Decreased functional β-cell mass in type 1 and type 2 diabetes is due to β-cell apoptosis and impaired secretory function suggested to be mediated, in part, by…”
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Release of incompletely processed proinsulin is the cause of the disproportionate proinsulinemia of NIDDM by Kahn, S. E., Halban, P. A.

“…Release of incompletely processed proinsulin is the cause of the disproportionate proinsulinemia of NIDDM. S E Kahn and P A Halban Department of Medicine, VA…”
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Suppression of Pdx-1 perturbs proinsulin processing, insulin secretion and GLP-1 signalling in INS-1 cells by WANG, H, IEZZI, M, THEANDER, S, ANTINOZZI, P. A, GAUTHIER, B. R, HALBAN, P. A, WOLLHEIM, C. B

“…Mutations in genes encoding HNF-4alpha, HNF-1alpha and IPF-1/Pdx-1 are associated with, respectively, MODY subtypes-1, -3 and -4. Impaired glucose-stimulated…”
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Isolation and characterization of VGF peptides in rat brain. Role of PC1/3 and PC2 in the maturation of VGF precursor by Trani, E., Giorgi, A., Canu, N., Amadoro, G., Rinaldi, A. M., Halban, P. A., Ferri, L., Possenti, R., Schininà†, M. E., Levi, A.

“…The neurotrophin responsive gene vgf is widely expressed in central and peripheral neurones, and in certain neuroendocrine cell populations. Its encoded VGF…”
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Hypercholesterolaemia, signs of islet microangiopathy and altered angiogenesis precede onset of type 2 diabetes in the Goto–Kakizaki (GK) rat by Giroix, M-H., Irminger, J-C., Lacraz, G., Noll, C., Calderari, S., Ehses, J. A., Coulaud, J., Cornut, M., Kassis, N., Schmidlin, F., Paul, J-L., Kergoat, M., Janel, N., Halban, P. A., Homo-Delarche, F.

“…Aims/hypothesis The adult non-obese Goto–Kakizaki (GK) rat model of type 2 diabetes, particularly females, carries in addition to hyperglycaemia a genetic…”
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Sorting and processing of secretory proteins by HALBAN, P. A, IRMINGER, J.-C

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innovative medicines initiative (IMI): a shot in the arm for European diabetes research by Halban, P. A

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Ectopic expression of the beta-cell specific transcription factor Pdx1 inhibits glucagon gene transcription by RITZ-LASER, B, GAUTHIER, B. R, ESTREICHER, A, MAMIN, A, BRUN, T, RIS, F, SALMON, P, HALBAN, P. A, TRONO, D, PHILIPPE, J

“…The transcription factor Pdx1 is required for the development and differentiation of all pancreatic cells. Beta-cell specific inactivation of Pdx1 in…”
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Chronic central neuropeptide Y infusion in normal rats : status of the hypothalamo-pituitary-adrenal axis, and vagal mediation of hyperinsulinaemia by SAINSBURY, A, ROHNER-JEANRENAUD, F, CUSIN, I, ZAKRZEWSKA, K. E, HALBAN, P. A, GAILLARD, R. C, JEANRENAUD, B

“…Neuropeptide Y in the hypothalamus is a potent physiological stimulator of feeding, and may contribute to the characteristic metabolic defects of obesity when…”
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Oligomerization of green fluorescent protein in the secretory pathway of endocrine cells by Jain, R K, Joyce, P B, Molinete, M, Halban, P A, Gorr, S U

“…Green fluorescent protein (GFP) is used extensively as a reporter protein to monitor cellular processes, including intracellular protein trafficking and…”
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Impact of integrin-matrix matching and inhibition of apoptosis on the survival of purified human beta-cells in vitro by RIS, F, HAMMAR, E, HALBAN, P. A, BOSCO, D, PILLOUD, C, MAEDLER, K, DONATH, M. Y, OBERHOLZER, J, ZEENDER, E, MOREL, P, ROUILLER, D

“…Human islet cells survive poorly in culture and are overgrown by non-endocrine cells. The aims of this study were to sort human beta cells and to develop…”
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Bimodal impact of skeletal muscle on pancreatic β-cell function in health and disease by Plomgaard, P., Halban, P. A., Bouzakri, K.

“…Diabetes is a complex disease that affects many organs directly or indirectly. Type 2 diabetes mellitus is characterized by insulin resistance with a relative…”
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Prime time for DIAMAP: a road map for diabetes research in Europe by Halban, P. A.

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Expression of neural cell adhesion molecule (N-CAM) in rat islets and its role in islet cell type segregation by CIRULLI, V, BAETENS, D, RUTISHAUSER, U, HALBAN, P. A, ROUILLER, D. G

“…Endocrine cell types are non-randomly distributed within pancreatic islets of Langerhans. In the rat, insulin-secreting B-cells occupy the core of the islets…”
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Mutational analysis of VAMP domains implicated in Ca2+‐induced insulin exocytosis by Regazzi, R., Sadoul, K., Meda, P., Kelly, R. B., Halban, P. A., Wollheim, C. B.

“…Vesicle‐associated membrane protein‐2 (VAMP‐2) and cellubrevin are associated with the membrane of insulin‐containing secretory granules and of…”
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Trafficking of non-regulated secretory proteins in insulin secreting (INS-1) cells by MOLINETE, M, LILLA, V, JAIN, R, JOYCE, P. B. M, GORR, S.-U, RAVAZZOLA, M, HALBAN, P. A

“…Sorting of proinsulin to the regulated secretory pathway of pancreatic beta cells and retention of insulin in dense-core granules of this pathway is remarkably…”
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