Search Results - "Halaweish, Fathi"

Cucurbitacins inspired organic synthesis: Potential dual inhibitors targeting EGFR – MAPK pathway by Mahnashi, Mater, Elgazwi, Sara M., Ahmed, Mahmoud Salama, Halaweish, Fathi T.

“…Natural products have been known as a fundamental source for drug discovery leading to the evolution of Biological Oriented Organic Synthesis (BIOS) approach…”
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In vitro and QSAR studies of cucurbitacins on HepG2 and HSC-T6 liver cell lines by Bartalis, Judit, Halaweish, Fathi T.

“…Cucurbitacin analogues with potential anticancer activity and hepatoprotective agents against fibrosis that deserve further examination. The aim of this study…”
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Cucurbitacin D exhibits potent anti-cancer activity in cervical cancer by Sikander, Mohammed, Hafeez, Bilal Bin, Malik, Shabnam, Alsayari, Abdulrhman, Halaweish, Fathi T., Yallapu, Murali M., Chauhan, Subhash C., Jaggi, Meena

“…In this study, we for the first time, investigated the potential anti-cancer effects of a novel analogue of cucurbitacin (Cucurbitacin D) against cervical…”
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Synthesis of novel pyridine and pyrimidine thioglycoside phosphoramidates for the treatment of COVID-19 and influenza A viruses by Abu-Zaied, Mamdouh A., Elgemeie, Galal H., Halaweish, Fathi T., Hammad, Sherif F.

“…A novel series of pyridine, cytosine, and uracil thioglycoside analogs (4a-i, 9a,b, and 13a,b, respectively) and their corresponding phosphoramidates (6a-I,…”
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Novel series of 6-(2-substitutedacetamido)-4-anilinoquinazolines as EGFR-ERK signal transduction inhibitors in MCF-7 breast cancer cells by Ismail, Rania S.M., Abou-Seri, Sahar M., Eldehna, Wagdy M., Ismail, Nasser S.M., Elgazwi, Sara M., Ghabbour, Hazem A., Ahmed, Mahmoud Salama, Halaweish, Fathi T., Abou El Ella, Dalal A.

“…Epidermal growth factor receptor (EGFR) signaling pathway has been previously investigated for its significant role in the progression of different types of…”
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Design, synthesis, and biological evaluation of steroidal analogs as estrogenic/anti-estrogenic agents by Alsayari, Abdulrhman, Kopel, Lucas, Ahmed, Mahmoud Salama, Pay, Adam, Carlson, Taylor, Halaweish, Fathi T.

“…[Display omitted] •Series of estrone analogs were synthesized.•Cell proliferation, cytotoxicity, and estrogenic/anti-estrogenic activities were evaluated.•LA-7…”
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Cucurbitacin D Reprograms Glucose Metabolic Network in Prostate Cancer by Sikander, Mohammed, Malik, Shabnam, Chauhan, Neeraj, Khan, Parvez, Kumari, Sonam, Kashyap, Vivek Kumar, Khan, Sheema, Ganju, Aditya, Halaweish, Fathi T, Yallapu, Murali M, Jaggi, Meena, Chauhan, Subhash C

“…Prostate cancer (PrCa) metastasis is the major cause of mortality and morbidity among men. Metastatic PrCa cells are typically adopted for aberrant glucose…”
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Deacetylated Sialic Acid Sensitizes Lung and Colon Cancers to Novel Cucurbitacin-Inspired Estrone Epidermal Growth Factor Receptor (EGFR) Inhibitor Analogs by Anim, Mathias T, Tuffour, Isaac, Willis, Rylan, Schell, Matthew, Ostlund, Trevor, Mahnashi, Mater H, Halaweish, Fathi, Willand-Charnley, Rachel

“…Cancers utilize sugar residues such as sialic acids (Sia) to improve their ability to survive. Sia presents a variety of functional group alterations,…”
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Ormeloxifene Suppresses Prostate Tumor Growth and Metastatic Phenotypes via Inhibition of Oncogenic β-catenin Signaling and EMT Progression by Hafeez, Bilal Bin, Ganju, Aditya, Sikander, Mohammed, Kashyap, Vivek K, Hafeez, Zubair Bin, Chauhan, Neeraj, Malik, Shabnam, Massey, Andrew E, Tripathi, Manish K, Halaweish, Fathi T, Zafar, Nadeem, Singh, Man M, Yallapu, Murali M, Chauhan, Subhash C, Jaggi, Meena

“…Ormeloxifene is a clinically approved selective estrogen receptor modulator, which has also shown excellent anticancer activity, thus it can be an ideal…”
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Nanoparticle formulation of ormeloxifene for pancreatic cancer by Khan, Sheema, Chauhan, Neeraj, Yallapu, Murali M, Ebeling, Mara C, Balakrishna, Swathi, Ellis, Robert T, Thompson, Paul A, Balabathula, Pavan, Behrman, Stephen W, Zafar, Nadeem, Singh, Man M, Halaweish, Fathi T, Jaggi, Meena, Chauhan, Subhash C

“…Abstract Pancreatic cancer is the fourth most prevalent cancer with about an 85% mortality rate; thus, an utmost need exists to discover new therapeutic…”
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Biological screening of cucurbitacin inspired estrone analogs targeting mitogen‐activated protein kinase (MAPK) pathway by Ahmed, Mahmoud S., El‐Senduny, Fardous, Taylor, Jessica, Halaweish, Fathi T.

“…Assembly of cucurbitacin inspired estrone analogs has been previously synthesized and screened against melanoma cell lines. Further synthetic optimization was…”
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Cucurbitacins: potential candidates targeting mitogen-activated protein kinase pathway for treatment of melanoma by Ahmed, Mahmoud S, Halaweish, Fathi T

“…Cucurbitacins (Cucs) have been classified as signal transducer and activator of transcription 3 inhibitors. Kinase inhibition has been a validated drug target…”
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Utilizing Estra-1,3,5,16-Tetraene Scaffold: Design and Synthesis of Nitric Oxide Donors as Chemotherapeutic Resistance Combating Agents in Liver Cancer by Abou-Salim, Mahrous A, Shaaban, Mohamed A, Abd El Hameid, Mohammed K, Alanazi, Mohammed M, Halaweish, Fathi, Elshaier, Yaseen A M M

“…A new series of nitric oxide-releasing estra-1,3,5,16-tetraene analogs (NO-∆-16-CIEAs) was designed and synthesized as dual inhibitors for EGFR and MRP2 based…”
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Sofosbuvir Thio-analogues: Synthesis and Antiviral Evaluation of the First Novel Pyridine- and Pyrimidine-Based Thioglycoside Phosphoramidates by Abu-Zaied, Mamdouh Attia, Hammad, Sherif F, Halaweish, Fathi T, Elgemeie, Galal Hamza

“…The synthesis and antiviral screening of the first reported series of pyridine- and pyrimidine-based thioglycoside phosphoramidates are herein reported. They…”
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Approach for chemosensitization of cisplatin-resistant ovarian cancer by cucurbitacin B by El-Senduny, Fardous F., Badria, Farid A., EL-Waseef, Ahmed M., Chauhan, Subhash C., Halaweish, Fathi

“…Ovarian cancer is the most deadly gynecological cancer. The first line in treatment is platinum-based drugs. However, most patients suffer from tumor…”
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Mechanistic investigation of hepato-protective potential for cucurbitacins by Arjaibi, Hajer M., Ahmed, Mahmoud S., Halaweish, Fathi T.

“…Hepatocellular carcinoma is a major example for inflammatory-associated cancer. cucurbitacins are natural triterpenoids known for their potent anticancer and…”
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Novel Mechanistic Insight into the Anticancer Activity of Cucurbitacin D against Pancreatic Cancer (Cuc D Attenuates Pancreatic Cancer) by Sikander, Mohammed, Malik, Shabnam, Khan, Sheema, Kumari, Sonam, Chauhan, Neeraj, Khan, Parvez, Halaweish, Fathi T, Chauhan, Bhavin, Yallapu, Murali M, Jaggi, Meena, Chauhan, Subhash C

“…Pancreatic cancer (PanCa) is one of the leading causes of death from cancer in the United States. The current standard treatment for pancreatic cancer is…”
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Structural Optimization and Biological Screening of a Steroidal Scaffold Possessing Cucurbitacin-Like Functionalities as B-Raf Inhibitors by Ahmed, Mahmoud S., Kopel, Lucas C., Halaweish, Fathi T.

“…Inhibition of the mitogen‐activated protein kinase (MAPK) pathway by targeting the commonly occurring mutated B‐Raf in melanoma has become a practical method…”
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Synthesis and Antitumor Activity of Brominated-Ormeloxifene (Br-ORM) against Cervical Cancer by Sikander, Mohammed, Malik, Shabnam, Apraku, John, Kumari, Sonam, Khan, Parvez, Mandil, Hassan, Ganju, Aditya, Chauhan, Bhavin, Bell, Maria C., Singh, Man Mohan, Khan, Sheema, Yallapu, Murali M., Halaweish, Fathi T., Jaggi, Meena, Chauhan, Subhash C.

“…Aberrant regulation of β-catenin signaling is strongly linked with cancer proliferation, invasion, migration, and metastasis, thus, small molecules that can…”
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The role of cucurbitacins in combating cancers: A mechanistic review by Alsayari, Abdulrhman, Halaweish, Fathi, Gurusamy, Narasimman

“…Cucurbitacins are highly oxidized tetracyclic triterpenoids from the Cucurbitaceae families. Several cucurbitacins, such as B, D, E, I, R, IIa, and…”
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