Search Results - "Halassa, Michael M."

Thalamic functions in distributed cognitive control by Halassa, Michael M., Kastner, Sabine

“…Cognition can be conceptualized as a set of algorithmic control functions whose real-time deployment determines how an organism stores and uses information to…”
Get full text

Thalamic control of functional cortical connectivity by Nakajima, Miho, Halassa, Michael M

“…Highlights • We introduce a framework in which the thalamus controls functional connectivity within and across cortical areas. • Thalamic control of cortical…”
Get full text

Thalamic amplification of cortical connectivity sustains attentional control by Schmitt, L. Ian, Wimmer, Ralf D., Nakajima, Miho, Happ, Michael, Mofakham, Sima, Halassa, Michael M.

“…The mediodorsal nucleus of the thalamus amplifies the functional connectivity of the prefrontal cortex, thereby sustaining cortical representations of rule…”
Get full text

Toward an Integrative Theory of Thalamic Function by Rikhye, Rajeev V, Wimmer, Ralf D, Halassa, Michael M

“…The thalamus has long been suspected to have an important role in cognition, yet recent theories have favored a more corticocentric view. According to this…”
Get full text

Integrated brain circuits: astrocytic networks modulate neuronal activity and behavior by Halassa, Michael M, Haydon, Philip G

“…The past decade has seen an explosion of research on roles of neuron-astrocyte interactions in the control of brain function. We highlight recent studies…”
Get full text

Thalamic control of sensory selection in divided attention by Wimmer, Ralf D., Schmitt, L. Ian, Davidson, Thomas J., Nakajima, Miho, Deisseroth, Karl, Halassa, Michael M.

“…The authors trained mice to attend to or suppress vision based on behavioral context and show, through novel and established techniques, that changes in visual…”
Get full text

IL-17a promotes sociability in mouse models of neurodevelopmental disorders by Reed, Michael Douglas, Yim, Yeong Shin, Wimmer, Ralf D., Kim, Hyunju, Ryu, Changhyeon, Welch, Gwyneth Margaret, Andina, Matias, King, Hunter Oren, Waisman, Ari, Halassa, Michael M., Huh, Jun R., Choi, Gloria B.

“…A subset of children with autism spectrum disorder appear to show an improvement in their behavioural symptoms during the course of a fever, a sign of systemic…”
Get full text

The impact of NMDA receptor hypofunction on GABAergic neurons in the pathophysiology of schizophrenia by Cohen, Samuel M, Tsien, Richard W, Goff, Donald C, Halassa, Michael M

“…Abstract While the dopamine hypothesis has dominated schizophrenia research for several decades, more recent studies have highlighted the role of fast synaptic…”
Get full text

Thalamic regulation of frontal interactions in human cognitive flexibility by Hummos, Ali, Wang, Bin A, Drammis, Sabrina, Halassa, Michael M, Pleger, Burkhard

“…Interactions across frontal cortex are critical for cognition. Animal studies suggest a role for mediodorsal thalamus (MD) in these interactions, but the…”
Get full text

Prefrontal Computation as Active Inference by Parr, Thomas, Rikhye, Rajeev Vijay, Halassa, Michael M, Friston, Karl J

“…Abstract The prefrontal cortex is vital for a range of cognitive processes, including working memory, attention, and decision-making. Notably, its absence…”
Get full text

The thalamus in psychosis spectrum disorder by Anticevic, Alan, Halassa, Michael M

“…Psychosis spectrum disorder (PSD) affects 1% of the world population and results in a lifetime of chronic disability, causing devastating personal and economic…”
Get full text

State-Dependent Architecture of Thalamic Reticular Subnetworks by Halassa, Michael M., Chen, Zhe, Wimmer, Ralf D., Brunetti, Philip M., Zhao, Shengli, Zikopoulos, Basilis, Wang, Fan, Brown, Emery N., Wilson, Matthew A.

“…Behavioral state is known to influence interactions between thalamus and cortex, which are important for sensation, action, and cognition. The thalamic…”
Get full text

An Ultra-Sensitive Step-Function Opsin for Minimally Invasive Optogenetic Stimulation in Mice and Macaques by Gong, Xin, Mendoza-Halliday, Diego, Ting, Jonathan T., Kaiser, Tobias, Sun, Xuyun, Bastos, André M., Wimmer, Ralf D., Guo, Baolin, Chen, Qian, Zhou, Yang, Pruner, Maxwell, Wu, Carolyn W.-H., Park, Demian, Deisseroth, Karl, Barak, Boaz, Boyden, Edward S., Miller, Earl K., Halassa, Michael M., Fu, Zhanyan, Bi, Guoqiang, Desimone, Robert, Feng, Guoping

“…Optogenetics is among the most widely employed techniques to manipulate neuronal activity. However, a major drawback is the need for invasive implantation of…”
Get full text

Astrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss by Halassa, Michael M., Florian, Cedrick, Fellin, Tommaso, Munoz, James R., Lee, So-Young, Abel, Ted, Haydon, Philip G., Frank, Marcos G.

“…Astrocytes modulate neuronal activity by releasing chemical transmitters via a process termed gliotransmission. The role of this process in the control of…”
Get full text

Rapid context inference in a thalamocortical model using recurrent neural networks by Zheng, Wei-Long, Wu, Zhongxuan, Hummos, Ali, Yang, Guangyu Robert, Halassa, Michael M.

“…Cognitive flexibility is a fundamental ability that enables humans and animals to exhibit appropriate behaviors in various contexts. The thalamocortical…”
Get full text

Sensation during Active Behaviors by Busse, Laura, Cardin, Jessica A, Chiappe, M Eugenia, Halassa, Michael M, McGinley, Matthew J, Yamashita, Takayuki, Saleem, Aman B

“…A substantial portion of our sensory experience happens during active behaviors such as walking around or paying attention. How do sensory systems work during…”
Get full text

Selective optical drive of thalamic reticular nucleus generates thalamic bursts and cortical spindles by Feng, Guoping, Moore, Christopher I, Halassa, Michael M, Siegle, Joshua H, Ritt, Jason T, Ting, Jonathan T

“…The thalamic reticular nucleus (TRN) is hypothesized to regulate neocortical rhythms and behavioral states. Using optogenetics and multi-electrode recording in…”
Get full text

Thalamic reticular nucleus induces fast and local modulation of arousal state by Lewis, Laura D, Voigts, Jakob, Flores, Francisco J, Schmitt, L Ian, Wilson, Matthew A, Halassa, Michael M, Brown, Emery N

“…During low arousal states such as drowsiness and sleep, cortical neurons exhibit rhythmic slow wave activity associated with periods of neuronal silence. Slow…”
Get full text

Thalamocortical contribution to flexible learning in neural systems by Wang, Mien Brabeeba, Halassa, Michael M.

“…Animal brains evolved to optimize behavior in dynamic environments, flexibly selecting actions that maximize future rewards in different contexts. A large body…”
Get full text

Variation of connectivity across exemplar sensory and associative thalamocortical loops in the mouse by Mukherjee, Arghya, Bajwa, Navdeep, Lam, Norman H, Porrero, César, Clasca, Francisco, Halassa, Michael M

“…The thalamus engages in sensation, action, and cognition, but the structure underlying these functions is poorly understood. Thalamic innervation of…”
Get full text