Search Results - "Halai, Reena"

Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression by Cuomo, Anna S. E., Seaton, Daniel D., McCarthy, Davis J., Martinez, Iker, Bonder, Marc Jan, Garcia-Bernardo, Jose, Amatya, Shradha, Madrigal, Pedro, Isaacson, Abigail, Buettner, Florian, Knights, Andrew, Natarajan, Kedar Nath, Vallier, Ludovic, Marioni, John C., Chhatriwala, Mariya, Stegle, Oliver

“…Recent developments in stem cell biology have enabled the study of cell fate decisions in early human development that are impossible to study in vivo…”
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Neutrophils—A Key Component of Ischemia-Reperfusion Injury by Schofield, Zoe Victoria, Woodruff, Trent Martin, Halai, Reena, Wu, Mike Chia-Lun, Cooper, Matthew Allister

“…ABSTRACTIschemia-reperfusion injury (IRI) is a common occurrence following myocardial infarction, transplantation, stroke, and trauma that can lead to multiple…”
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Glycopeptide antibiotics: Back to the future by Butler, Mark S, Hansford, Karl A, Blaskovich, Mark A T, Halai, Reena, Cooper, Matthew A

“…Glycopeptide antibiotics have been a key weapon in the fight against bacterial infections for over half a century, with the progenitors, vancomycin ( 1 ) and…”
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Cardelino: computational integration of somatic clonal substructure and single-cell transcriptomes by McCarthy, Davis J., Rostom, Raghd, Huang, Yuanhua, Kunz, Daniel J., Danecek, Petr, Bonder, Marc Jan, Hagai, Tzachi, Lyu, Ruqian, Wang, Wenyi, Gaffney, Daniel J., Simons, Benjamin D., Stegle, Oliver, Teichmann, Sarah A.

“…Bulk and single-cell DNA sequencing has enabled reconstructing clonal substructures of somatic tissues from frequency and cooccurrence patterns of somatic…”
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Population-scale proteome variation in human induced pluripotent stem cells by Mirauta, Bogdan Andrei, Seaton, Daniel D, Bensaddek, Dalila, Brenes, Alejandro, Bonder, Marc Jan, Kilpinen, Helena, Stegle, Oliver, Lamond, Angus I

“…Human disease phenotypes are driven primarily by alterations in protein expression and/or function. To date, relatively little is known about the variability…”
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ConoServer, a database for conopeptide sequences and structures by Kaas, Quentin, Westermann, Jan-C., Halai, Reena, Wang, Conan K. L., Craik, David J.

“…ConoServer is a new database dedicated to conopeptides, a large family of peptides found in the venom of marine snails of the genus Conus. These peptides have…”
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Publisher Correction: Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression by Cuomo, Anna S. E., Seaton, Daniel D., McCarthy, Davis J., Martinez, Iker, Bonder, Marc Jan, Garcia-Bernardo, Jose, Amatya, Shradha, Madrigal, Pedro, Isaacson, Abigail, Buettner, Florian, Knights, Andrew, Natarajan, Kedar Nath, Vallier, Ludovic, Marioni, John C., Chhatriwala, Mariya, Stegle, Oliver

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Induction of Neural Crest Stem Cells From Bardet-Biedl Syndrome Patient Derived hiPSCs by Barrell, William B, Griffin, John N, Harvey, Jessica-Lily, Danovi, Davide, Beales, Philip, Grigoriadis, Agamemnon E, Liu, Karen J

“…Neural crest cells arise in the embryo from the neural plate border and migrate throughout the body, giving rise to many different tissue types such as bones…”
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A Comparative Study of Impedance versus Optical Label-Free Systems Relative to Labelled Assays in a Predominantly Gi Coupled GPCR (C5aR) Signalling by Halai, Reena, Croker, Daniel E, Suen, Jacky Y, Fairlie, David P, Cooper, Matthew A

“…Profiling ligand function on G-protein coupled receptors (GPCRs) typically involves using transfected cells over-expressing a target of interest, a labelled…”
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Pharmacological Inhibition of the Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome with MCC950 by Corcoran, Sarah E, Halai, Reena, Cooper, Matthew A

“…Activation of the Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome drives release of the proinflammatory cytokines interleukin (IL)-1…”
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Common genetic variation drives molecular heterogeneity in human iPSCs by Kilpinen, Helena, Goncalves, Angela, Leha, Andreas, Afzal, Vackar, Alasoo, Kaur, Ashford, Sofie, Bala, Sendu, Bensaddek, Dalila, Casale, Francesco Paolo, Culley, Oliver J., Danecek, Petr, Faulconbridge, Adam, Harrison, Peter W., Kathuria, Annie, McCarthy, Davis, McCarthy, Shane A., Meleckyte, Ruta, Memari, Yasin, Moens, Nathalie, Soares, Filipa, Mann, Alice, Streeter, Ian, Agu, Chukwuma A., Alderton, Alex, Nelson, Rachel, Harper, Sarah, Patel, Minal, White, Alistair, Patel, Sharad R., Clarke, Laura, Halai, Reena, Kirton, Christopher M., Kolb-Kokocinski, Anja, Beales, Philip, Birney, Ewan, Danovi, Davide, Lamond, Angus I., Ouwehand, Willem H., Vallier, Ludovic, Watt, Fiona M., Durbin, Richard, Stegle, Oliver, Gaffney, Daniel J.

“…Technology utilizing human induced pluripotent stem cells (iPS cells) has enormous potential to provide improved cellular models of human disease. However,…”
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Conotoxins: natural product drug leads by Halai, Reena, Craik, David J

“…Venomous marine cone snails harbour a variety of small disulfide-rich peptides called conotoxins, which target a broad range of ion channels, membrane…”
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Effects of Cyclization on Stability, Structure, and Activity of α-Conotoxin RgIA at the α9α10 Nicotinic Acetylcholine Receptor and GABA B Receptor by Halai, Reena, Callaghan, Brid, Daly, Norelle L., Clark, Richard J., Adams, David J., Craik, David J.

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C5a2 can modulate ERK1/2 signaling in macrophages via heteromer formation with C5a1 and β‐arrestin recruitment by Croker, Daniel E, Halai, Reena, Kaeslin, Geraldine, Wende, Elisabeth, Fehlhaber, Beate, Klos, Andreas, Monk, Peter N, Cooper, Matthew A

“…The complement system is a major component of our innate immune system, in which the complement proteins C5a and C5a‐des Arg bind to two G‐protein‐coupled…”
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C5a, but not C5a‐des Arg, induces upregulation of heteromer formation between complement C5a receptors C5aR and C5L2 by Croker, Daniel E, Halai, Reena, Fairlie, David P, Cooper, Matthew A

“…Receptors for C5a have an important role in innate immunity and inflammation where their expression and activation is tightly regulated. There are two known…”
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Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling by Croker, Daniel E, Monk, Peter N, Halai, Reena, Kaeslin, Geraldine, Schofield, Zoe, Wu, Mike CL, Clark, Richard J, Blaskovich, Mark AT, Morikis, Dimitrios, Floudas, Christodoulos A, Cooper, Matthew A, Woodruff, Trent M

“…The complement cascade is comprised of a highly sophisticated network of innate immune proteins that are activated in response to invading pathogens or tissue…”
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Using label-free screening technology to improve efficiency in drug discovery by Halai, Reena, Cooper, Matthew A

“…Screening assays have traditionally utilized reporter labels to quantify biological responses relevant to the disease state of interest. However, there are…”
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Effects of Cyclization on Stability, Structure, and Activity of α-Conotoxin RgIA at the α9α10 Nicotinic Acetylcholine Receptor and GABAB Receptor by Halai, Reena, Callaghan, Brid, Daly, Norelle L, Clark, Richard J, Adams, David J, Craik, David J

“…α-Conotoxin RgIA is of interest as a lead in the development of drugs for neuropathic pain. It modulates the α9α10 nicotinic acetylcholine receptor (nAChR) and…”
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Scanning Mutagenesis of α-Conotoxin Vc1.1 Reveals Residues Crucial for Activity at the α9α10 Nicotinic Acetylcholine Receptor by Halai, Reena, Clark, Richard J., Nevin, Simon T., Jensen, Jonas E., Adams, David J., Craik, David J.

“…Vc1.1 is a disulfide-rich peptide inhibitor of nicotinic acetylcholine receptors that has stimulated considerable interest in these receptors as potential…”
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Characterisation of small molecule ligands 4CMTB and 2CTAP as modulators of human FFA2 receptor signalling by Schofield, Zoe V., Croker, Daniel, Robertson, Avril A. B., Massey, Nicholas L., Donovan, Chantal, Tee, Ernest, Edwards, David, Woodruff, Trent M., Halai, Reena, Hansbro, Philip M., Cooper, Matthew A.

“…Short chain fatty acids (SCFAs) are protective against inflammatory diseases. Free fatty acid receptor 2 (FFA2), is a target of SCFAs however, their…”
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