Search Results - "Halade, Ganesh V."

Inflammation and resolution signaling in cardiac repair and heart failure by Halade, Ganesh V., Lee, Dae Hyun

“…Unresolved inflammation is a key mediator of advanced heart failure. Especially, damage, pathogen, and lifestyle-associated molecular patterns are the major…”
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Immune responsive resolvin D1 programs peritoneal macrophages and cardiac fibroblast phenotypes in diversified metabolic microenvironment by Kain, Vasundhara, Halade, Ganesh V.

“…Bioactive lipid mediators derived from n‐3 and n‐6 fatty acids are known to modulate leukocytes. Metabolic transformation of essential fatty acids to…”
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Exercise reduces pro-inflammatory lipids and preserves resolution mediators that calibrate macrophage-centric immune metabolism in spleen and heart following obesogenic diet in aging mice by Halade, Ganesh V., Upadhyay, Gunjan, Marimuthu, MathanKumar, Wanling, Xuan, Kain, Vasundhara

“…The study investigated the role of volunteer exercise and an obesogenic diet (OBD) in mice, focusing on the splenocardiac axis and inflammation-resolution…”
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Matrix metalloproteinase (MMP)-9: A proximal biomarker for cardiac remodeling and a distal biomarker for inflammation by HALADE, Ganesh V, JIN, Yu-Fang, LINDSEY, Merry L

“…Adverse cardiac remodeling following myocardial infarction (MI) remains a significant cause of congestive heart failure. Additional and novel strategies that…”
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Guidelines for in vivo mouse models of myocardial infarction by Lindsey, Merry L, Brunt, Keith R, Kirk, Jonathan A, Kleinbongard, Petra, Calvert, John W, de Castro Brás, Lisandra E, DeLeon-Pennell, Kristine Y, Del Re, Dominic P, Frangogiannis, Nikolaos G, Frantz, Stefan, Gumina, Richard J, Halade, Ganesh V, Jones, Steven P, Ritchie, Rebecca H, Spinale, Francis G, Thorp, Edward B, Ripplinger, Crystal M, Kassiri, Zamaneh

“…Despite significant improvements in reperfusion strategies, acute coronary syndromes all too often culminate in a myocardial infarction (MI). The consequent MI…”
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Heart functional and structural compendium of cardiosplenic and cardiorenal networks in acute and chronic heart failure pathology by Halade, Ganesh V, Kain, Vasundhara, Ingle, Kevin A

“…Heart failure (HF) secondary to myocardial infarction (MI) is linked to kidney complications that comprise cellular, structural, functional, and survival…”
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Myocardial SERCA2 Protects Against Cardiac Damage and Dysfunction Caused by Inhaled Bromine by Masjoan Juncos, Juan Xavier, Nadeem, Fahad, Shakil, Shazia, El-Husari, Malik, Zafar, Iram, Louch, William E, Halade, Ganesh V, Zaky, Ahmed, Ahmad, Aftab, Ahmad, Shama

“…Myocardial sarcoendoplasmic reticulum calcium ATPase 2 (SERCA2) activity is critical for heart function. We have demonstrated that inhaled halogen (chlorine or…”
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Molecular and Cellular Differences in Cardiac Repair of Male and Female Mice by Pullen, Amanda B, Kain, Vasundhara, Serhan, Charles N, Halade, Ganesh V

“…Background Leukocyte-directed biosynthesis of specialized proresolving mediators (SPMs) orchestrates physiological inflammation after myocardial infarction…”
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Sphingosine-1-phosphate interactions in the spleen and heart reflect extent of cardiac repair in mice and failing human hearts by B Gowda, SiddabasaveGowda, Gowda, Divyavani, Kain, Vasundhara, Chiba, Hitoshi, Hui, Shu-Ping, Chalfant, Charles E, Parcha, Vibhu, Arora, Pankaj, Halade, Ganesh V

“…Sphingosine-1-phosphate (S1P) is a bioactive mediator in inflammation. Dysregulated S1P is demonstrated as a cause of heart failure (HF). However, the…”
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Matrix Metalloproteinase-28 Deletion Exacerbates Cardiac Dysfunction and Rupture After Myocardial Infarction in Mice by Inhibiting M2 Macrophage Activation by Ma, Yonggang, Halade, Ganesh V, Zhang, Jianhua, Ramirez, Trevi A, Levin, Daniel, Voorhees, Andrew, Jin, Yu-Fang, Han, Hai-Chao, Manicone, Anne M, Lindsey, Merry L

“…RATIONALE:Matrix metalloproteinase (MMP)-28 regulates the inflammatory and extracellular matrix responses in cardiac aging, but the roles of MMP-28 after…”
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Adaptive immunity-driven inflammation and cardiovascular disease by Ilatovskaya, Daria V, Halade, Ganesh V, DeLeon-Pennell, Kristine Y

“…The adaptive immune response has recently emerged as an important factor in a wide variety of cardiovascular disorders including atherosclerosis, hypertension,…”
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Cardiomyocyte-specific Bmal1 deletion in mice triggers diastolic dysfunction, extracellular matrix response, and impaired resolution of inflammation by Ingle, Kevin A, Kain, Vasundhara, Goel, Mehak, Prabhu, Sumanth D, Young, Martin E, Halade, Ganesh V

“…The mammalian circadian clock consists of multiple transcriptional regulators that coordinate biological processes in a time-of-day-dependent manner…”
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Temporal lipid profiling in the progression from acute to chronic heart failure in mice and ischemic human hearts by Gowda, Siddabasave Gowda B., Gowda, Divyavani, Hou, Fengjue, Chiba, Hitoshi, Parcha, Vibhu, Arora, Pankaj, Halade, Ganesh V., Hui, Shu-Ping

“…Myocardial infarction (MI) is a leading cause of heart failure (HF). After MI, lipids undergo several phasic changes implicated in cardiac repair if…”
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Dually Responsive Poly( N -vinylcaprolactam)- b -poly(dimethylsiloxane)- b -poly( N -vinylcaprolactam) Polymersomes for Controlled Delivery by Kozlovskaya, Veronika, Yang, Yiming, Liu, Fei, Ingle, Kevin, Ahmad, Aftab, Halade, Ganesh V, Kharlampieva, Eugenia

“…Limited tissue selectivity and targeting of anticancer therapeutics in systemic administration can produce harmful side effects in the body. Various polymer…”
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Lipoxygenase inhibitor ML351 dysregulated an innate inflammatory response leading to impaired cardiac repair in acute heart failure by Tourki, Bochra, Black, Laurence M., Kain, Vasundhara, Halade, Ganesh V.

“…The presistent increase of 12/15 lipoxygenase enzyme activity is correlated with uncontrolled inflammation, leading to organ dysfunction. ML351, a potent 12/15…”
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Subacute treatment of carprofen facilitate splenocardiac resolution deficit in cardiac injury by Halade, Ganesh V., Kain, Vasundhara, Wright, Griffin M., Jadapalli, Jeevan Kumar

“…Inflammation‐limiting nonsteroidal pain relievers magnify myocardial infarction (MI) incidences and increase re‐admission events in heart failure (HF)…”
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Bone Benefits of Fish Oil Supplementation Depend on its EPA and DHA Content by Abou-Saleh, Haissam, Ouhtit, Allal, Halade, Ganesh V, Rahman, Md Mizanur

“…The preventive effect of high-dose (9%) regular-fish oil (FO) against bone loss during aging has been demonstrated, but the effects of a low-dose (1%-4%) of a…”
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Mitoquinone ameliorates pressure overload-induced cardiac fibrosis and left ventricular dysfunction in mice by Goh, Kah Yong, He, Li, Song, Jiajia, Jinno, Miki, Rogers, Aaron J, Sethu, Palaniappan, Halade, Ganesh V, Rajasekaran, Namakkal Soorappan, Liu, Xiaoguang, Prabhu, Sumanth D, Darley-Usmar, Victor, Wende, Adam R, Zhou, Lufang

“…Increasing evidence indicates that mitochondrial-associated redox signaling contributes to the pathophysiology of heart failure (HF). The…”
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High fat diet-induced animal model of age-associated obesity and osteoporosis by Halade, Ganesh V., Rahman, Md M., Williams, Paul J., Fernandes, Gabriel

“…Osteoporosis and obesity remain a major public health concern through its associated fragility and fractures. Several animal models for the study of…”
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Heart Failure Syndrome With Preserved Ejection Fraction Is a Metabolic Cluster of Non-resolving Inflammation in Obesity by Tourki, Bochra, Halade, Ganesh V.

“…Heart failure with preserved ejection fraction (HFpEF) is an emerging disease with signs of nonresolving inflammation, endothelial dysfunction, and multiorgan…”
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