Search Results - "Hakulinen, P."

Phase I/II study of ODM-203, a selective dual FGFR/VEGFR inhibitor, in patients with advanced solid tumours by Bono, P, Massard, C, Peltola, K, Azaro, A, Italiano, A, Kristeleit, R S, Lassen, U N, Arkenau, H-T, Hakulinen, P, Garratt, C, Ikonen, T, Mustonen, M, Rodon, J

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Estrogenic effects of toremifene and tamoxifen in postmenopausal breast cancer patients by ELLMEN, J, HAKULINEN, P, PARTANEN, A, HAYES, D. F

“…Intrinsic estrogenicities of the selective estrogen receptor modulators (SERMs) toremifene 60 mg daily or 200 mg daily and tamoxifen 20 mg daily (TOR60, TOR200…”
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Assessment of the genotoxicity of the rat carcinogen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5 H)-furanone (MX) in rat liver epithelial cells in vitro by Mäki-Paakkanen, J., Hakulinen, P.

“…3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5 H)-furanone (MX), a disinfection by-product in chlorinated drinking water, is a multisite carcinogen in rats. One…”
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The BIOSAFEPAPER project for in vitro toxicity assessments: Preparation, detailed chemical characterisation and testing of extracts from paper and board samples by Bradley, E.L., Honkalampi-Hämäläinen, U., Weber, A., Andersson, M.A., Bertaud, F., Castle, L., Dahlman, O., Hakulinen, P., Hoornstra, D., Lhuguenot, J.-C., Mäki-Paakkanen, J., Salkinoja-Salonen, M., Speck, D.R., Severin, I., Stammati, A., Turco, L., Zucco, F., von Wright, A.

“…Nineteen food contact papers and boards and one non-food contact board were extracted following test protocols developed within European Union funded project…”
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Safety evaluation of food contact paper and board using chemical tests and in vitro bioassays: role of known and unknown substances by Honkalampi-Hämäläinen, U., Bradley, E.L., Castle, L., Severin, I., Dahbi, L., Dahlman, O., Lhuguenot, J.-C., Andersson, M.A., Hakulinen, P., Hoornstra, D., Mäki-Paakkanen, J., Salkinoja-Salonen, M., Turco, L., Stammati, A., Zucco, F., Weber, A., von Wright, A.

“…In vitro toxicological tests have been proposed as an approach to complement the chemical safety assessment of food contact materials, particularly those with…”
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Test procedures for obtaining representative extracts suitable for reliable in vitro toxicity assessment of paper and board intended for food contact by Bradley, E.L., Stammati, A., Salkinoja-Salonen, M., Andersson, M., Bertaud, F., Hoornstra, D., Zucco, F., Weber, A., Turco, L., Traussnig, H., Hakulinen, P., Speck, D.R., Von Wright, A.J., Honkalampi-Hämäläinen, U., Mäki-Paakkanen, J., Severin, I., Lhuguenot, J.-C., Dahlman, O.

“…This paper describes the use of a suite of extraction procedures applicable to the assessment of the in vitro toxicity of paper/board samples intended for…”
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Selegiline as the primary treatment of Parkinson's disease - a long-term double-blind study by Myllylä, V. V., Sotaniemi, K. A., Hakulinen, P., Mäki-lkola, O., Heinonen, E. H.

“…Introduction – To assess the therapeutic efficacy of selegiline combined with levodopa in the long‐term treatment of Parkinson's disease (PD). Material and…”
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420PPhase I/II study of ODM-203, a selective dual FGFR/VEGFR inhibitor, in patients with advanced solid tumours by Bono, P, Massard, C, Peltola, K, Azaro, A, Italiano, A, Kristeleit, R S, Lassen, U N, Arkenau, H-T, Hakulinen, P, Garratt, C, Ikonen, T, Mustonen, M, Rodon, J

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A double-blind, randomized, placebo-controlled crossover trial of the  2C-adrenoceptor antagonist ORM-12741 for prevention of cold-induced vasospasm in patients with systemic sclerosis by Herrick, A. L., Murray, A. K., Ruck, A., Rouru, J., Moore, T. L., Whiteside, J., Hakulinen, P., Wigley, F., Snapir, A.

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Toxicological profile of cereulide, the Bacillus cereus emetic toxin, in functional assays with human, animal and bacterial cells by Andersson, Maria A., Hakulinen, Pasi, Honkalampi-Hämäläinen, Ulla, Hoornstra, Douwe, Lhuguenot, Jean-Claude, Mäki-Paakkanen, Jorma, Savolainen, Martti, Severin, Isabelle, Stammati, Anna-Laura, Turco, Laura, Weber, Assi, von Wright, Atte, Zucco, Flavia, Salkinoja-Salonen, Mirja

“…Some strains of the endospore-forming bacterium Bacillus cereus produce a heat-stable ionophoric peptide, cereulide, of high human toxicity. We assessed cell…”
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Altered expression of connexin43 in the inhibition of gap junctional intercellular communication by chlorohydroxyfuranones in WB-F344 rat liver epithelial cells by Hakulinen, Pasi, Rintala, Elina, Mäki-Paakkanen, Jorma, Komulainen, Hannu

“…3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5 H)-furanone (MX), 3,4-dichloro-5-hydroxy-2(5 H)-furanone (MCA), and 3-chloro-4-methyl-5-hydroxy-2(5 H)-furanone (MCF)…”
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Potent inhibition of gap junctional intercellular communication by 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5 H)-furanone (MX) in BALB/c 3T3 cells by Hakulinen, Pasi, Mäki-Paakkanen, Jorma, Naarala, Jonne, Kronberg, Leif, Komulainen, Hannu

“…The chlorohydroxyfuranones (CHFs) MX [3-chloro-4-(dichloromethyl)-5-hydroxy-2(5 H)-furanone], MCA [3,4-dichloro-5-hydroxy-2(5 H)-furanone], CMCF…”
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Expression of p53 and p21 Ki-ras proteins in rat thyroid gland tumors induced by 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) by Hakulinen, Pasi, Kosma, Veli-Matti, Komulainen, Hannu

“…3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), a disinfection by-product in chlorinated drinking water, induces follicular tumors in thyroid glands…”
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CARDIORESPIRATORY FITNESS AND SERUM TRIGLYCERIDES IN RELATION TO APO E GENOTYPE: THE DNASCO -STUDY 522 by Rauramaa, R., Vaisanen, S., Rankinen, T., Hakulinen, P., Ryynanen, M., Suomela-Markkanen, T., Bouchard, C.

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No consistent pattern of mutations in p53 and ras genes in liver tumors of rat treated with the drinking water mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) by Komulainen, Hannu, Hakulinen, Pasi, Servomaa, Kristina, Makkonen, Kaisa, Vasara, Ritva, Mäki-Paakkanen, Jorma, Kosma, Veli-Matti

“…The frequency of point mutations in p53 (exons 4–7) and in Ki‐ras, Ha‐ras, and N‐ras (exons 1 and 2) and the expression of p53 protein were evaluated in the…”
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Dose-dependent hormonal effects of toremifene in postmenopausal breast cancer patients by ELLMEN, J, WERNER, D, HAKULINEN, P, KEILING, R, FARGEOT, P, FALKSON, G, BEZWODA, W. R

“…The purpose of the study was to compare hormonal effects of three toremifene doses, 20 mg (TOR20), 40 mg (TOR40) and 60 mg (TOR60) administered daily, in…”
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