Search Results - "Hakoi, K"

Chronological monitoring of miR-122 is sensitive and essential for pathologic reflection of hepatobiliary toxicity in vivo and in vitro by Hitotsumachi, H., Fujieda, M., Yamaguchi, M., Moriyama, K., Besshi, K., Morita, F., Hakoi, K.

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Modification of N-butyl-N-(4-hydroxybutyl)nitrosamine-initiated urinary bladder carcinogenesis in rats by phytic acid and its salts by Takaba, K, Hirose, M, Ogawa, K, Hakoi, K, Fukushima, S

“…The effects of dietary phytic acid and its salts on the promotion stage of two-stage urinary bladder carcinogenesis were examined. Male F344 rats were…”
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Tumours of the kidney by Tsuda, H, Kim, D J, Kato, T, Hakoi, K, Hagiwara, A

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A 26-week oral repeated dose toxicity study of a new antineoplastic agent S-1 in rats by HAKOI, K, HAYASHI, T, OHMAE, S, BESSHI, K

“…S-1 was administered to male and female rats by gavage for 26 weeks at 0, 1, 5, and 10 mg/kg/day followed by 5-week recovery period for the control, 5, and 10…”
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A rapid in vivo bioassay for the carcinogenicity of pesticides by Cabral, R, Hoshiya, T, Hakoi, K, Hasegawa, R, Fukushima, S, Ito, N

“…Eight pesticides were tested in a bioassay based on the induction of preneoplastic lesions in the liver. Rats were given diethylnitrosamine intraperitoneally…”
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Lack of carcinogenicity of daminozide, alone or in combination with its contaminant 1,1-dimethylhydrazine, in a medium-term bioassay by Cabral, R, Hakoi, K, Hoshiya, T, Hasegawa, R, Ito, N

“…The carcinogenicity of daminozide (succinic acid-2,2-dimethylhydrazide; Alar), a plant growth regulator used primarily in apple orchards, has been the subject…”
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Analysis of carcinogenic activity of some pesticides in a medium-term liver bioassay in the rat by Hakoi, K, Cabral, R, Hoshiya, T, Hasegawa, R, Shirai, T, Ito, N

“…Eight pesticides were tested in a medium-term bioassay based upon the induction of preneoplastic lesions in the liver. Rats were initially given…”
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Proliferation and alteration of hepatic peroxisomes and reduction of ATPase activity on their limiting membrane after oral administration of acetylsaliatic acid (aspirin) for four weeks to male rats by Makita, T, Hakoi, K

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JTE‐522, a selective cyclooxygenase‐2 inhibitor, inhibits induction but not growth and invasion of 1,2‐dimethylhydrazine‐induced tubular adenocarcinomas of colon in rats by Wei, Min, Morimura, Keiichirou, Wanibuchi, Hideki, Shen, Jun, Salim, Elsayed I., Moku, Masaharu, Hakoi, Katsuo, Fukushima, Shoji

“…We have previously demonstrated that JTE‐522, a selective cyclooxygenase‐2 (COX‐2) inhibitor, inhibited development of aberrant crypt foci (ACF) in rats, a…”
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Enhancing effects of diallyl sulfide on hepatocarcinogenesis and inhibitory actions of the related diallyl disulfide on colon and renal carcinogenesis in rats by Takahashi, S, Hakoi, K, Yada, H, Hirose, M, Ito, N, Fukushima, S

“…It has been reported that diallyl sulfide (DS) and diallyl disulfide (DDS), major volatile compounds in garlic (Allium sativum), exert anticarcinogenic…”
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Ultrastructural localization of magnesium-dependent adenosine triphosphatase in dog hepatic peroxisomes treated with a peroxisome proliferator, acetylsalicyclic acid by HAKOI, K, MAKITA, T

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Cell proliferation and advancement of hepatocarcinogenesis in the rat are associated with a decrease in connexin 32 expression by Tsuda, H, Asamoto, M, Baba, H, Iwahori, Y, Matsumoto, K, Iwase, T, Nishida, Y, Nagao, S, Hakoi, K, Yamaguchi, S

“…The expression of connexin 32 (Cx32), a major liver gap junction protein, after partial hepatectomy (PH) and during development and progression of…”
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Enhancement of GST-P positive liver cell foci development by combined treatment of rats with five heterocyclic amines at low doses by Ito, N, Hasegawa, R, Shirai, T, Fukushima, S, Hakoi, K, Takaba, K, Iwasaki, S, Wakabayashi, K, Nagao, M, Sugimura, T

“…Potential synergism between five heterocyclic amines at low doses was evaluated in a medium-term liver bioassay system for carcinogens. F344 male rats were…”
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Medium-term bioassay for the hepatocarcinogenicity of hexachlorobenzene by Cabral, Ricardo, Hoshiya, Toru, Hakoi, Kazuo, Hasegawa, Ryohei, Ito, Nobuyuki

“…Hexachlorobenzene (HCB) is an important environmental contaminant derived mainly from industrial and agricultural sources. It is carcinogenic in mice, rats and…”
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Sequential Morphological and Biological Changes in the Glandular Stomach Induced by Oral Administration of Catechol to Male F344 Rats by Hirose, Masao, Hakoi, Kazuo, Takahashi, Satoru, Hoshiya, Toru, Akagi, Keisuke, Cuilin, Saito, Koichi, Kaneko, Hideo, Shirai, Tomoyuki

“…Histogenesis and mechanisms of catechol-induced rat glandular stomach carcinogenesis were investigated in male F344 rats. Groups of 5 or 6 rats were treated…”
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Modification of carcinogenesis by alpha-tocopherol, t-butylhydroquinone, propyl gallate and butylated hydroxytoluene in a rat multi-organ carcinogenesis model by Hirose, M, Yada, H, Hakoi, K, Takahashi, S, Ito, N

“…Effects of the dietary antioxidants alpha-tocopherol (alpha-Toc), t-butylhydroquinone (TBHQ), propyl gallate (PG) and butylated hydroxytoluene (BHT) were…”
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Enhancement by non-mutagenic pesticides of GST-P positive hepatic foci development initiated with diethylnitrosamine in the rat by Hoshiya, T, Hasegawa, R, Hakoi, K, Cui, L, Ogiso, T, Cabral, R, Ito, N

“…The potential hepatocarcinogenicity of seven pesticides was examined using a rapid bioassay based on the induction of glutathione S-transferase placental form…”
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Carcinogenic potential of some pesticides in a medium-term multi-organ bioassay in rats by Hasegawa, R, Cabral, R, Hoshiya, T, Hakoi, K, Ogiso, T, Boonyaphiphat, P, Shirai, T, Ito, N

“…The carcinogenic potential of 5 pesticides was analyzed using a medium-term multi-organ bioassay for carcinogenicity. Male F344 rats were initially treated…”
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Comparison of Reversibility of Rat Forestomach Lesions Induced by Genotoxic and Non‐genotoxic Carcinogens by Kagawa, Masataka, Hakoi, Kazuo, Yamamoto, Atsushi, Futakuchi, Mitsuru, Hirose, Masao

“…Reversibility of forestomach lesions induced by genotoxic and non‐genotoxic carcinogens was compared histopathologically. Groups of 30 to 33 male F344 rats…”
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Synergistic Enhancement of Glutathione S–Transferase Placental Form–positive Hepatic Foci Development in Diethylnitrosamine–treated Rats by Combined Administration of Five Heterocyclic Amines at Low Doses by Hasegawa, Ryohei, Shirai, Tomoyuki, Hakoi, Kazuo, Takaba, Katsumi, Iwasaki, Shogo, Hoshiya, Toru, Ito, Nobuyuki, Nagao, Minako, Takashi, Takashi

“…Potential synergism among 5 heterocyclic amines at low doses in the induction of glutathione S–transferase placental form (GST–P)–positive liver cell foci was…”
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