Search Results - "Hakkarainen, Jenni J"

Viability of Mouse Retinal Explant Cultures Assessed by Preservation of Functionality and Morphology by Alarautalahti, Virpi, Ragauskas, Symantas, Hakkarainen, Jenni J, Uusitalo-Järvinen, Hannele, Uusitalo, Hannu, Hyttinen, Jari, Kalesnykas, Giedrius, Nymark, Soile

“…Retinal explant cultures provide simplified systems where the functions of the retina and the effects of ocular therapies can be studied in an isolated…”
Get full text

Penetration Enhancers for Topical Drug Delivery to the Ocular Posterior Segment-A Systematic Review by Thareja, Abhinav, Hughes, Helen, Alvarez-Lorenzo, Carmen, Hakkarainen, Jenni J, Ahmed, Zubair

“…There is an unmet clinical need for eye drop formulations to efficiently treat the diseases of the posterior ocular segment by non-invasive topical…”
Get full text

Acute cytotoxic effects of marketed ophthalmic formulations on human corneal epithelial cells by Hakkarainen, Jenni J., Reinisalo, Mika, Ragauskas, Symantas, Seppänen, Aila, Kaja, Simon, Kalesnykas, Giedrius

“…[Display omitted] The purpose of the study was to devise a fast, reliable and sensitive cell viability assay for assessment of acute cytotoxicity on human…”
Get full text

Introducing an Efficient In Vitro Cornea Mimetic Model for Testing Drug Permeability by Žiniauskaitė, Agnė, Cėpla, Vytautas, Jelinskas, Tadas, Eimont, Romuald, Ulčinas, Artūras, Aldonytė, Rūta, Valiokas, Ramūnas, Kalesnykas, Giedrius, Hakkarainen, Jenni J.

“…There is a growing need for novel in vitro corneal models to replace animal-based ex vivo tests in drug permeability studies. In this study, we demonstrated a…”
Get full text

Comparison of in vitro cell models in predicting in vivo brain entry of drugs by Hakkarainen, Jenni J., Jalkanen, Aaro J., Kääriäinen, Tiina M., Keski-Rahkonen, Pekka, Venäläinen, Tetta, Hokkanen, Juho, Mönkkönen, Jukka, Suhonen, Marjukka, Forsberg, Markus M.

“…Although several in vitro models have been reported to predict the ability of drug candidates to cross the blood–brain barrier, their real in vivo relevance…”
Get full text

Improving corneal permeability of dexamethasone using penetration enhancing agents: First step towards achieving topical drug delivery to the retina by Thareja, Abhinav, Leigh, Thomas, Hakkarainen, Jenni J., Hughes, Helen, Alvarez-Lorenzo, Carmen, Fernandez-Trillo, Francisco, Blanch, Richard J., Ahmed, Zubair

“…[Display omitted] •Eye-drops of dexamethasone sodium-phosphate with penetration enhancing agents to increase bioavailability in the posterior segment.•A novel…”
Get full text

PLL-g-PEG Polymer Inhibits Antibody-Drug Conjugate Uptake into Human Corneal Epithelial Cells In Vitro by Kleinman, David, Iqbal, Sana, Ghosh, Anita K, Ogle, Sean D, Kaja, Simon, Mitchnick, Mark, Hakkarainen, Jenni J

“…Antibody-drug conjugates (ADCs) are a relatively recent advance in the delivery of chemotherapeutics that improve targeting of cytotoxic agents. However,…”
Get more information

A novel approach of increasing bioavailability of drug molecules to the posterior ocular segment through topical administration using penetration enhancing agents by Thareja, Abhinav, Leigh, Thomas, Hakkarainen, Jenni J., Alvarez‐Lorenzo, Carmen, Hughes, Helen, Fernandez‐Trillo, Francisco, Blanch, Richard J., Ahmed, Zubair

“…A major cause of blindness worldwide is disease and damage in the posterior ocular segment. Due to poor penetration of therapeutic molecules, topical eye drops…”
Get full text

Efficacy of Trabodenoson in a Mouse Keratoconjunctivitis Sicca (KCS) Model for Dry-Eye Syndrome by Žiniauskaite, Agne, Ragauskas, Symantas, Hakkarainen, Jenni J, Rich, Cadmus C, Baumgartner, Rudolf, Kalesnykas, Giedrius, Albers, David S, Kaja, Simon

“…To determine the efficacy of trabodenoson, an adenosine mimetic with highly selective adenosine A1 receptor binding properties, in a preclinical mouse model…”
Get full text

Genetically Modified Caco-2 Cells With Improved Cytochrome P450 Metabolic Capacity by Küblbeck, Jenni, Hakkarainen, Jenni J, Petsalo, Aleksanteri, Vellonen, Kati-Sisko, Tolonen, Ari, Reponen, Petri, Forsberg, Markus M, Honkakoski, Paavo

“…The human intestinal Caco-2 cell line has been extensively used as a model of small intestinal absorption but it lacks expression and function of cytochrome…”
Get more information

Manganese(III) tetrakis(1-methyl-4-pyridyl) porphyrin, a superoxide dismutase mimetic, reduces disease severity in in vitro and in vivo models for dry-eye disease by Žiniauskaitė, Agnė, Ragauskas, Symantas, Ghosh, Anita K., Thapa, Rubina, Roessler, Anne E., Koulen, Peter, Kalesnykas, Giedrius, Hakkarainen, Jenni J., Kaja, Simon

“…To determine the efficacy of the superoxide dismutase mimetic, manganese(III) tetrakis(1-methyl-4-pyridyl) porphyrin (Mn-TM-2-PyP), in vitro in human corneal…”
Get full text

Brain pharmacokinetics of ganciclovir in rats with orthotopic BT4C glioma by Gynther, Mikko, Kääriäinen, Tiina M, Hakkarainen, Jenni J, Jalkanen, Aaro J, Petsalo, Aleksanteri, Lehtonen, Marko, Peura, Lauri, Kurkipuro, Jere, Samaranayake, Haritha, Ylä-Herttuala, Seppo, Rautio, Jarkko, Forsberg, Markus M

“…Ganciclovir (GCV) is an essential part of the Herpes simplex virus thymidine kinase (HSV-tk) gene therapy of malignant gliomas. The purpose of this study was…”
Get full text

Similar molecular descriptors determine the in vitro drug permeability in endothelial and epithelial cells by Hakkarainen, Jenni J., Pajander, Jari, Laitinen, Riikka, Suhonen, Marjukka, Forsberg, Markus M.

“…Endothelial and epithelial cells are commonly used for assessing blood–brain barrier (BBB) permeability of the drug candidates. However, the additional value…”
Get full text

The effect of prolyl oligopeptidase inhibition on extracellular acetylcholine and dopamine levels in the rat striatum by Jalkanen, Aaro J., Piepponen, T. Petteri, Hakkarainen, Jenni J., De Meester, Ingrid, Lambeir, Anne-Marie, Forsberg, Markus M.

“…► The effects of PREP inhibitors on ACh and DA levels in rat striatum were studied by microdialysis. ► JTP-4819 decreased ACh levels by 25–50% after systemic…”
Get full text

Re-evaluation of the role of P-glycoprotein in in vitro drug permeability studies with the bovine brain microvessel endothelial cells by Hakkarainen, Jenni J., Rilla, Kirsi, Suhonen, Marjukka, Ruponen, Marika, Forsberg, Markus M.

“…Abstract 1. Currently available in vitro blood-brain barrier models all have recognized restrictions. In addition to leakiness, inconsistent data about…”
Get full text

Brain Pharmacokinetics of Two Prolyl Oligopeptidase Inhibitors, JTP‐4819 and KYP‐2047, in the Rat by Jalkanen, Aaro J., Hakkarainen, Jenni J., Lehtonen, Marko, Venäläinen, Tetta, Kääriäinen, Tiina M., Jarho, Elina, Suhonen, Marjukka, Forsberg, Markus M.

“…:  Prolyl oligopeptidase (PREP) inhibitors are potential drug candidates for the treatment of neurological disorders, but little is known about their ability…”
Get full text

Brain Pharmacokinetics of Two Prolyl Oligopeptidase Inhibitors, JTP-4819 and KYP-2047, in the Rat: BRAIN PHARMACOKINETICS OF PROLYL OLIGOPEPTIDASE INHIBITORS by Jalkanen, Aaro J., Hakkarainen, Jenni J., Lehtonen, Marko, Venäläinen, Tetta, Kääriäinen, Tiina M., Jarho, Elina, Suhonen, Marjukka, Forsberg, Markus M.

Get full text