Search Results - "Hakizimana, Pierre"
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Inner hair cell stereocilia are embedded in the tectorial membrane
Published in Nature communications (10-05-2021)“…Mammalian hearing depends on sound-evoked displacements of the stereocilia of inner hair cells (IHCs), which cause the endogenous mechanoelectrical transducer…”
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2
The summating potential polarity encodes the ear health condition
Published in Cellular and molecular life sciences : CMLS (01-06-2023)“…The summating potential (SP), the DC potential which, along with the AC response, is produced when the hair cells convert the vibrational mechanical energy of…”
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3
Sound-induced length changes in outer hair cell stereocilia
Published in Nature communications (2012)“…Hearing relies on mechanical stimulation of stereocilia bundles on the sensory cells of the inner ear. When sound hits the ear, each stereocilium pivots about…”
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Outer Hair Cell Lateral Wall Structure Constrains the Mobility of Plasma Membrane Proteins
Published in PLoS genetics (01-09-2015)“…Nature's fastest motors are the cochlear outer hair cells (OHCs). These sensory cells use a membrane protein, Slc26a5 (prestin), to generate mechanical force…”
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The sensitivity of mechanoelectrical transduction response phase to acoustic overstimulation is calcium-dependent
Published in Pflügers Archiv (01-02-2024)“…The Mechanoelectrical transduction (MET) channels of the mammalian hair cells are essential for converting sound stimuli into electrical signals that enable…”
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Interactions between Phosphatidylethanolamine Headgroup and LmrP, a Multidrug Transporter
Published in The Journal of biological chemistry (04-04-2008)“…In a number of cases, the function of membrane proteins appears to require the presence of specific lipid species in the bilayer. We have shown that the…”
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7
A randomised, double blind trial of N-Acetylcysteine for hearing protection during stapes surgery
Published in PloS one (12-03-2015)“…Otosclerosis is a disorder that impairs middle ear function, leading to conductive hearing loss. Surgical treatment results in large improvement of hearing at…”
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Membrane cholesterol modulates cochlear electromechanics
Published in Pflügers Archiv (01-06-2011)Get full text
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Control of hearing sensitivity by tectorial membrane calcium
Published in Proceedings of the National Academy of Sciences - PNAS (19-03-2019)“…When sound stimulates the stereocilia on the sensory cells in the hearing organ, Ca2+ ions flow through mechanically gated ion channels. This Ca2+ influx is…”
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Effects of salicylate on sound-evoked outer hair cell stereocilia deflections
Published in Pflügers Archiv (01-09-2015)“…Hearing depends on sound-evoked deflections of the stereocilia that protrude from the sensory hair cells in the inner ear. Although sound provides an important…”
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Best frequencies and temporal delays are similar across the low-frequency regions of the guinea pig cochlea
Published in Science advances (23-09-2022)“…The cochlea maps tones with different frequencies to distinct anatomical locations. For instance, a faint 5000-hertz tone produces brisk responses at a place…”
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Membrane cholesterol modulates cochlear electromechanics
Published in Pflügers Archiv (01-06-2011)“…Changing the concentration of cholesterol in the plasma membrane of isolated outer hair cells modulates electromotility and prestin-associated charge movement,…”
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Interactions between Phosphatidylethanolamine Headgroup and LmrP, a Multidrug Transporter: A CONSERVED MECHANISM FOR PROTON GRADIENT SENSING?
Published in The Journal of biological chemistry (04-04-2008)“…In a number of cases, the function of membrane proteins appears to require the presence of specific lipid species in the bilayer. We have shown that the…”
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14
High-frequency hearing, tinnitus and patient satisfaction with stapedotomy: A randomized prospective study
Published in Scientific reports (21-08-2015)“…Otosclerosis is a common disorder that leads to conductive hearing loss. Most patients with otosclerosis also have tinnitus and surgical treatment is known to…”
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Sound Transduction in the Mammalian Outer Hair Cells: Prestin Activity is Required for Proper Deflection of the Stereocilia Bundle
Published in BIOPHYSICAL JOURNAL (01-01-2010)Get full text
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Outer Hair Cell Lateral Wall Structure Constrains the Mobility of Plasma Membrane Proteins: e1005500
Published in PLoS genetics (01-09-2015)“…Nature's fastest motors are the cochlear outer hair cells (OHCs). These sensory cells use a membrane protein, Slc26a5 (prestin), to generate mechanical force…”
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Conformational changes in a bacterial multidrug transporter are phosphatidylethanolamine-dependent
Published in Cellular and molecular life sciences : CMLS (01-06-2007)“…LmrP is an electrogenic H⁺/drug antiporter that extrudes a broad spectrum of antibiotics. Five carboxylic residues are implicated in drug binding (Asp142 and…”
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