Search Results - "Hakemeyer, Christian"

At-line NIR spectroscopy as effective PAT monitoring technique in Mab cultivations during process development and manufacturing by Hakemeyer, Christian, Strauss, Ulrike, Werz, Silke, Jose, Gledson E., Folque, Francisca, Menezes, Jose C.

“…► NIRS on supernatant samples from Mab cultivation processes spanning several production scales, CHO cell lines and development years. ► NIRS is effective in…”
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The way to a design space for an animal cell culture process according to Quality by Design (QbD) by Puskeiler, Robert, Kreuzmann, Jan, Schuster, Caroline, Didzus, Katharina, Bartsch, Nicole, Hakemeyer, Christian, Schmidt, Heike, Jacobs, Melanie, Wolf, Stefan

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Complete clarification solution for processing high density cell culture harvests by Tomic, Sladjana, Besnard, Lise, Fürst, Benjamin, Reithmeier, Rainer, Wichmann, Rolf, Schelling, Pierre, Hakemeyer, Christian

“…•Flocculation approach simplifies the clarification of high cell density cultures.•Depth filter area is reduced for a more economical clarification…”
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Process characterization and Design Space definition by Hakemeyer, Christian, McKnight, Nathan, St. John, Rick, Meier, Steven, Trexler-Schmidt, Melody, Kelley, Brian, Zettl, Frank, Puskeiler, Robert, Kleinjans, Annika, Lim, Fred, Wurth, Christine

“…Quality by design (QbD) is a global regulatory initiative with the goal of enhancing pharmaceutical development through the proactive design of pharmaceutical…”
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Predicting mab product yields from cultivation media components, using near-infrared and 2D-fluorescence spectroscopies by Jose, Gledson E., Folque, Francisca, Menezes, Jose C., Werz, Silke, Strauss, Ulrike, Hakemeyer, Christian

“…The yield of monoclonal antibody (Mab) production processes depends on media formulation, inocula quality, and process conditions. As in industrial processes…”
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Near-infrared and two-dimensional fluorescence spectroscopy monitoring of monoclonal antibody fermentation media quality: Aged media decreases cell growth by Hakemeyer, Christian, Strauss, Ulrike, Werz, Silke, Folque, Francisca, Menezes, Jose C.

“…In biomanufacturing processes, the influence of feedstock components on product yield and quality is considerable and often poorly understood. Here we describe…”
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Characterization of the influence of cultivation parameters on extracellular modifications of antibodies during fermentation by Hakemeyer, Christian, Pech, Martin, Lipok, Gero, Herrmann, Alexander

“…Doc number: P85…”
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Predicting MAb Product Yields from Cultivation Media Components Using NIR Spectroscopy by Folque, Francisca, Menezes, Jose C., Kleeb, Andreas, Dalenbrook-Heil, Britta, Werz, Silke, Strauss, Ulrike, Hakemeyer, Christian

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Discerning key parameters influencing high productivity and quality through recognition of patterns in process data by Le, Huong, Castro-Melchor, Marlene, Hakemeyer, Christian, Jung, Christine, Szperalski, Berthold, Karypis, George, Hu, Wei-Shou

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