Search Results - "Hakan Alakus"

Sex-specific prognostic effect of CD66b-positive tumor-infiltrating neutrophils (TANs) in gastric and esophageal adenocarcinoma by Quaas, Alexander, Pamuk, Aylin, Klein, Sebastian, Quantius, Jennifer, Rehkaemper, Jan, Barutcu, Atakan G., Rueschoff, Josef, Zander, Thomas, Gebauer, Florian, Hillmer, Axel, Buettner, Reinhard, Schroeder, Wolfgang, Bruns, Christiane J., Löser, Heike, Schoemig-Markiefka, Birgid, Alakus, Hakan

“…Background Tumor-associated neutrophils (TANs) have recently been identified as a relevant component of the tumor microenvironment (TME) in solid tumors…”
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MST1R kinase accelerates pancreatic cancer progression via effects on both epithelial cells and macrophages by Babicky, Michele L., Harper, Megan M., Chakedis, Jeffery, Cazes, Alex, Mose, Evangeline S., Jaquish, Dawn V., French, Randall P., Childers, Betzaira, Alakus, Hakan, Schmid, Michael C., Foubert, Phillippe, Miyamoto, Jaclyn, Holman, Patrick J., Walterscheid, Zakkary J., Tang, Chih-Min, Varki, Nissi, Sicklick, Jason K., Messer, Karen, Varner, Judith A., Waltz, Susan E., Lowy, Andrew M.

“…The MST1R (RON) kinase is overexpressed in >80% of human pancreatic cancers, but its role in pancreatic carcinogenesis is unknown. In this study, we examined…”
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Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data by Hescheler, Daniel A., Plum, Patrick S., Zander, Thomas, Quaas, Alexander, Korenkov, Michael, Gassa, Asmae, Michel, Maximilian, Bruns, Christiane J., Alakus, Hakan

“…Background So far only trastuzumab, pembrolizumab and ramucirumab have been approved by the FDA for targeted therapy in gastric cancer (GC). Here we report on…”
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Loss of the SWI/SNF-ATPase subunit members SMARCF1 (ARID1A), SMARCA2 (BRM), SMARCA4 (BRG1) and SMARCB1 (INI1) in oesophageal adenocarcinoma by Schallenberg, Simon, Bork, Julian, Essakly, Ahlem, Alakus, Hakan, Buettner, Reinhard, Hillmer, Axel M, Bruns, Christiane, Schroeder, Wolfgang, Zander, Thomas, Loeser, Heike, Gebauer, Florian, Quaas, Alexander

“…The SWI/SNF complex is an important chromatin remodeler, commonly dysregulated in cancer, with an estimated mutation frequency of 20%. ARID1A is the most…”
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The expression of the immune checkpoint regulator VISTA correlates with improved overall survival in pT1/2 tumor stages in esophageal adenocarcinoma by Loeser, Heike, Kraemer, Max, Gebauer, Florian, Bruns, Christiane, Schröder, Wolfgang, Zander, Thomas, Persa, Oana-Diana, Alakus, Hakan, Hoelscher, Arnulf, Buettner, Reinhard, Lohneis, Philipp, Quaas, Alexander

“…Immune checkpoint modulation in cancer has been demonstrated as a high-value therapeutic strategy in many tumor entities. VISTA is an immune checkpoint…”
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HER2/neu (ERBB2) expression and gene amplification correlates with better survival in esophageal adenocarcinoma by Plum, Patrick Sven, Gebauer, Florian, Krämer, Max, Alakus, Hakan, Berlth, Felix, Chon, Seung-Hun, Schiffmann, Lars, Zander, Thomas, Büttner, Reinhard, Hölscher, Arnulf Heinrich, Bruns, Christiane Josephine, Quaas, Alexander, Loeser, Heike

“…HER2 (ERBB2 or HER2/neu) is a tyrosine-kinase increasing cell proliferation. Overexpression/amplification of HER2 is correlated with worse prognosis in solid…”
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Tumor-Derived Extracellular Vesicles Inhibit Natural Killer Cell Function in Pancreatic Cancer by Zhao, Jiangang, Schlößer, Hans A, Wang, Zhefang, Qin, Jie, Li, Jiahui, Popp, Felix, Popp, Marie Christine, Alakus, Hakan, Chon, Seung-Hun, Hansen, Hinrich P, Neiss, Wolfram F, Jauch, Karl-Walter, Bruns, Christiane J, Zhao, Yue

“…Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies. Tumor-derived extracellular vesicles (EVs) induce pre-metastatic niche…”
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Lymphocyte activation gene-3 (LAG3) mRNA and protein expression on tumour infiltrating lymphocytes (TILs) in oesophageal adenocarcinoma by Gebauer, Florian, Krämer, Max, Bruns, Christiane, Schlößer, Hans A., Thelen, Martin, Lohneis, Philipp, Schröder, Wolfgang, Zander, Thomas, Alakus, Hakan, Buettner, Reinhard, Loeser, Heike, Quaas, Alexander

“…Purpose Lymphocyte activation gene-3 (LAG3) is an immunosuppressive checkpoint molecule expressed on T cells. The frequency and distribution of LAG3 expression…”
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Long-term quality of life after surgery for adenocarcinoma of the esophagogastric junction: extended gastrectomy or transthoracic esophagectomy? by Fuchs, Hans, Hölscher, Arnulf H., Leers, Jessica, Bludau, Marc, Brinkmann, Sebastian, Schröder, Wolfgang, Alakus, Hakan, Mönig, Stefan, Gutschow, Christian A.

“…Background Esophagectomy with gastric tube reconstruction and extended transhiatal gastrectomy with Roux-en-Y reconstruction are alternative procedures in…”
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Fetal gut cell-like differentiation in esophageal adenocarcinoma defines a rare tumor subtype with therapeutically relevant claudin-6 positivity and SWI/SNF gene alteration by Kraemer, Max, Zander, Thomas, Alakus, Hakan, Buettner, Reinhard, Lyu, Su Ir, Simon, Adrian Georg, Schroeder, Wolfgang, Bruns, Christiane J., Quaas, Alexander

“…Esophageal adenocarcinoma (EAC) is one of the deadliest tumor entities worldwide, with a 5-year survival rate of less than 25%. Unlike other tumor entities,…”
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Immune profile and immunosurveillance in treatment-naive and neoadjuvantly treated esophageal adenocarcinoma by Wagener-Ryczek, Svenja, Schoemmel, Max, Kraemer, Max, Bruns, Christiane, Schroeder, Wolfgang, Zander, Thomas, Gebauer, Florian, Alakus, Hakan, Merkelbach-Bruse, Sabine, Buettner, Reinhard, Loeser, Heike, Thelen, Martin, Schlößer, Hans A., Quaas, Alexander

“…The outcome in esophageal adenocarcinoma (EAC) is still poor with only 20% of patients in Western populations surviving for more than 5 years. Almost nothing…”
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Short-term outcome of Ivor Lewis esophagectomy following neoadjuvant chemoradiation versus perioperative chemotherapy in patients with locally advanced adenocarcinoma of the esophagus and gastroesophageal junction: a propensity score-matched analysis by Plum, Patrick Sven, Damanakis, Alexander, Buschmann, Lisa, Ernst, Angela, Datta, Rabi Raj, Schiffmann, Lars Mortimer, Zander, Thomas, Fuchs, Hans, Chon, Seung-Hun, Alakus, Hakan, Schröder, Wolfgang, Hölscher, Arnulf Heinrich, Bruns, Christiane Josephine, Bludau, Marc

“…Background Patients with locally advanced esophageal or gastroesophageal adenocarcinoma benefit from multimodal therapy concepts including neoadjuvant…”
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Inflammatory IFIT3 renders chemotherapy resistance by regulating post-translational modification of VDAC2 in pancreatic cancer by Wang, Zhefang, Qin, Jie, Zhao, Jiangang, Li, Jiahui, Li, Dai, Popp, Marie, Popp, Felix, Alakus, Hakan, Kong, Bo, Dong, Qiongzhu, Nelson, Peter J, Zhao, Yue, Bruns, Christiane J

“…Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers worldwide and effective therapy remains a challenge. IFIT3 is an…”
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The tight junction protein claudin 6 is a potential target for patient-individualized treatment in esophageal and gastric adenocarcinoma and is associated with poor prognosis by Simon, Adrian Georg, Lyu, Su Ir, Laible, Mark, Wöll, Stefan, Türeci, üzlem, Åahin, UÄur, Alakus, Hakan, Fahrig, Luca, Zander, Thomas, Buettner, Reinhard, Bruns, Christiane Josephine, Schroeder, Wolfgang, Gebauer, Florian, Quaas, Alexander

“…Background The prognosis of esophageal adenocarcinoma (EAC) and gastric adenocarcinoma (GAC) remains poor, and new therapeutic approaches are urgently needed…”
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PIK3CA and KRAS Amplification in Esophageal Adenocarcinoma and their Impact on the Inflammatory Tumor Microenvironment and Prognosis by Essakly, Ahlem, Loeser, Heike, Kraemer, Max, Alakus, Hakan, Chon, Seung-Hun, Zander, Thomas, Buettner, Reinhard, Hillmer, Axel M., Bruns, Christiane J., Schroeder, Wolfgang, Gebauer, Florian, Quaas, Alexander

“…Gene amplifications of PIK3CA or KRAS induce a downstream activation of the AKT-mTOR or RAF-ERK-pathways. Interactions of the active AKT pathway have been…”
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Amplification of KRAS and its heterogeneity in non-Asian gastric adenocarcinomas by Rehkaemper, Jan, Korenkov, Michael, Quaas, Alexander, Rueschoff, Josef, Pamuk, Aylin, Zander, Thomas, Hillmer, Axel M, Buettner, Reinhard, Hoelscher, Arnulf Heinrich, Bruns, Christiane Josephine, Loeser, Heike, Alakus, Hakan, Schoemig-Markiefka, Birgid

“…Gastric cancer is one of the deadliest cancer entities worldwide. While surgery is the only curative treatment option in early tumors, for locally advanced and…”
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Mesothelin expression in esophageal adenocarcinoma and squamous cell carcinoma and its possible impact on future treatment strategies by Moentenich, Valeska, Comut, Erdem, Gebauer, Florian, Tuchscherer, Armin, Bruns, Christiane, Schroeder, Wolfgang, Buettner, Reinhard, Alakus, Hakan, Loeser, Heike, Zander, Thomas, Quaas, Alexander

“…Background: Mesothelin is expressed at very low levels by normal mesothelial cells but is overexpressed in several human cancers. This makes mesothelin a…”
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GATA binding protein 6 (GATA6) is co-amplified with PIK3CA in patients with esophageal adenocarcinoma and is linked to neoadjuvant therapy by Plum, Patrick Sven, Löser, Heike, Zander, Thomas, Essakly, Ahlem, Bruns, Christiane J., Hillmer, Axel M., Alakus, Hakan, Schröder, Wolfgang, Büttner, Reinhard, Gebauer, Florian, Quaas, Alexander

“…Purpose Driver mutations are typically absent in esophageal adenocarcinoma (EAC). Mostly, oncogenes are amplified as driving molecular events (including…”
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Occurrence of High Microsatellite-Instability/Mismatch Repair Deficiency in Nearly 2,000 Human Adenocarcinomas of the Gastrointestinal Tract, Pancreas, and Bile Ducts: A Study From a Large German Comprehensive Cancer Center by Quaas, Alexander, Rehkaemper, Jan, Rueschoff, Josef, Pamuk, Aylin, Zander, Thomas, Hillmer, Axel, Siemanowski, Janna, Wittig, Jana, Buettner, Reinhard, Plum, Patrick, Popp, Felix, Gebauer, Florian, Bruns, Christiane Josephine, Loeser, Heike, Alakus, Hakan, Schoemig-Markiefka, Birgid

“…INTRODUCTIONKnowledge of the high microsatellite-instability (MSI-H)/mismatch repair deficiency (MMRd) status is of increasing interest for personalized…”
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Both GLUT-1 and GLUT-14 are Independent Prognostic Factors in Gastric Adenocarcinoma by Berlth, Felix, Mönig, Stefan, Pinther, Berit, Grimminger, Peter, Maus, Martin, Schlösser, Hans, Plum, Patrick, Warnecke-Eberz, Ute, Harismendy, Olivier, Drebber, Uta, Bollschweiler, Elfriede, Hölscher, Arnulf, Alakus, Hakan

“…Background The role of glucose transporter 14 (GLUT-14/SLC2A14) in tumor biology is entirely unknown, and the significance of hypoxia inducible factor 1-alpha…”
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