Search Results - "Hajj, Glaucia N"

Translating tumour immunity control by Hajj, Glaucia N. M.

“…In this Journal Club, Hajj discusses a study demonstrating that oncogene activation modulates immune control through both transcription and translation…”
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Establishment and Comprehensive Molecular Characterization of an Immortalized Glioblastoma Cell Line from a Brazilian Patient by da Silva, Fernanda F., Lupinacci, Fernanda C. S., Elias, Bruno D. S., Beserra, Adriano O., Sanematsu, Paulo, Roffe, Martin, Kulikowski, Leslie D., Costa, Felipe D’almeida, Santos, Tiago G., Hajj, Glaucia N. M.

“…Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults, with few effective treatment strategies. The research on the development of…”
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Polysome-profiling in small tissue samples by Liang, Shuo, Bellato, Hermano Martins, Lorent, Julie, Lupinacci, Fernanda C S, Oertlin, Christian, van Hoef, Vincent, Andrade, Victor P, Roffé, Martín, Masvidal, Laia, Hajj, Glaucia N M, Larsson, Ola

“…Abstract Polysome-profiling is commonly used to study translatomes and applies laborious extraction of efficiently translated mRNA (associated with >3…”
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Aberrant expression of RSK1 characterizes high‐grade gliomas with immune infiltration by M. Hajj, Glaucia N., Silva, Fernanda F., Bellis, Bárbara, Lupinacci, Fernanda C. S., Bellato, Hermano M., Cruz, Juvanier R., Segundo, Claudionor N. C., Faquini, Igor V., Torres, Leuridan C., Sanematsu, Paulo I., Begnami, Maria D., Martins, Vilma R., Roffé, Martín

“…The p90 ribosomal S6 kinase (RSK) family, a downstream target of Ras/extracellular signal‐regulated kinase signaling, can mediate cross‐talk with the mammalian…”
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unconventional secretion of stress-inducible protein 1 by a heterogeneous population of extracellular vesicles by Hajj, Glaucia N. M, Arantes, Camila P, Dias, Marcos Vinicios Salles, Roffé, Martín, Costa-Silva, Bruno, Lopes, Marilene H, Porto-Carreiro, Isabel, Rabachini, Tatiana, Lima, Flávia R, Beraldo, Flávio H, Prado, Marco M. A, Linden, Rafael, Martins, Vilma R

“…The co-chaperone stress-inducible protein 1 (STI1) is released by astrocytes, and has important neurotrophic properties upon binding to prion protein (PrPC)…”
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Interaction of Cellular Prion and Stress-Inducible Protein 1 Promotes Neuritogenesis and Neuroprotection by Distinct Signaling Pathways by Lopes, Marilene H, Hajj, Glaucia N. M, Muras, Angelita G, Mancini, Gabriel L, Castro, Rosa M. P. S, Ribeiro, Karina C. B, Brentani, Ricardo R, Linden, Rafael, Martins, Vilma R

“…Understanding the physiological function of the cellular prion (PrPc) depends on the investigation of PrPc-interacting proteins. Stress-inducible protein 1…”
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Two widely used RSK inhibitors, BI-D1870 and SL0101, alter mTORC1 signaling in a RSK-independent manner by Roffé, Martín, Lupinacci, Fernanda C., Soares, Luana C., Hajj, Glaucia N., Martins, Vilma R.

“…The 90kDa ribosomal S6 kinases (RSK) are effectors of the Ras-ERK1/2 signaling pathway. RSK signaling controls proliferation and protein synthesis, and is…”
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PRNP/prion protein regulates the secretion of exosomes modulating CAV1/caveolin-1-suppressed autophagy by Dias, Marcos V. S., Teixeira, Bianca L., Rodrigues, Bruna R., Sinigaglia-Coimbra, Rita, Porto-Carreiro, Isabel, Roffé, Martín, Hajj, Glaucia N. M., Martins, Vilma R.

“…Prion protein modulates many cellular functions including the secretion of trophic factors by astrocytes. Some of these factors are found in exosomes, which…”
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Amyloid‐beta oligomers increase the localization of prion protein at the cell surface by Caetano, Fabiana A., Beraldo, Flavio H., Hajj, Glaucia N. M., Guimaraes, Andre L., Jürgensen, Sofia, Wasilewska‐Sampaio, Ana Paula, Hirata, Pedro H. F., Souza, Ivana, Machado, Cleiton F., Wong, Daisy Y.‐L., De Felice, Fernanda G., Ferreira, Sergio T., Prado, Vania F., Rylett, R. Jane, Martins, Vilma R., Prado, Marco A. M.

“…J. Neurochem. (2011) 117, 538–553. In Alzheimer’s disease, the amyloid‐β peptide (Aβ) interacts with distinct proteins at the cell surface to interfere with…”
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Endocytosis of Prion Protein Is Required for ERK1/2 Signaling Induced by Stress-Inducible Protein 1 by Caetano, Fabiana A, Lopes, Marilene H, Hajj, Glaucia N. M, Machado, Cleiton F, Pinto Arantes, Camila, Magalhaes, Ana C, Vieira, Monica De Paoli B, Americo, Tatiana A, Massensini, Andre R, Priola, Suzette A, Vorberg, Ina, Gomez, Marcus V, Linden, Rafael, Prado, Vania F, Martins, Vilma R, Prado, Marco A. M

“…The secreted cochaperone STI1 triggers activation of protein kinase A (PKA) and ERK1/2 signaling by interacting with the cellular prion (PrP(C)) at the cell…”
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The prion protein ligand, stress-inducible phosphoprotein 1, regulates amyloid-β oligomer toxicity by Ostapchenko, Valeriy G, Beraldo, Flavio H, Mohammad, Amro H, Xie, Yu-Feng, Hirata, Pedro H F, Magalhaes, Ana C, Lamour, Guillaume, Li, Hongbin, Maciejewski, Andrzej, Belrose, Jillian C, Teixeira, Bianca L, Fahnestock, Margaret, Ferreira, Sergio T, Cashman, Neil R, Hajj, Glaucia N M, Jackson, Michael F, Choy, Wing-Yiu, MacDonald, John F, Martins, Vilma R, Prado, Vania F, Prado, Marco A M

“…In Alzheimer's disease (AD), soluble amyloid-β oligomers (AβOs) trigger neurotoxic signaling, at least partially, via the cellular prion protein (PrP(C))…”
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Cellular prion protein interaction with vitronectin supports axonal growth and is compensated by integrins by Hajj, Glaucia N.M, Lopes, Marilene H, Mercadante, Adriana F, Veiga, Silvio S, da Silveira, Rafael B, Santos, Tiago G, Ribeiro, Karina C.B, Juliano, Maria A, Jacchieri, Saul G, Zanata, Silvio M, Martins, Vilma R

“…The physiological functions of the cellular prion protein, PrPC, as a cell surface pleiotropic receptor are under debate. We report that PrPC interacts with…”
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Stress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotection by Zanata, Silvio M., Lopes, Marilene H., Mercadante, Adriana F., Hajj, Glaucia N. M., Chiarini, Luciana B., Nomizo, Regina, Freitas, Adriana R. O., Cabral, Ana L. B., Lee, Kil S., Juliano, Maria A., de Oliveira, Elizabeth, Jachieri, Saul G., Burlingame, Alma, Huang, Lan, Linden, Rafael, Brentani, Ricardo R., Martins, Vilma R.

“…Prions are composed of an isoform of a normal sialoglycoprotein called PrPc, whose physiological role has been under investigation, with focus on the screening…”
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Malignant pleural mesothelioma: an update by Hajj, Glaucia N M, Cavarson, Carolina H, Pinto, Clóvis Antônio Lopes, Venturi, Gabriela, Navarro, João R, Lima, Vladmir C Cordeiro de

“…Malignant mesotheliomas are rare types of cancers that affect the mesothelial surfaces, usually the pleura and peritoneum. They are associated with asbestos…”
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Prion-induced Activation of Cholesterogenic Gene Expression by Srebp2 in Neuronal Cells by Bach, Christian, Gilch, Sabine, Rost, Romina, Greenwood, Alex D., Horsch, Marion, Hajj, Glaucia N.M., Brodesser, Susanne, Facius, Axel, Schädler, Sandra, Sandhoff, Konrad, Beckers, Johannes, Leib-Mösch, Christine, Schätzl, Hermann M., Vorberg, Ina

“…Prion diseases are neurodegenerative diseases associated with the accumulation of a pathogenic isoform of the host-encoded prion protein. The cellular…”
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Prion protein ablation increases cellular aggregation and embolization contributing to mechanisms of metastasis by Muras, Angelita G., Hajj, Glaucia N.M., Ribeiro, Karina B., Nomizo, Regina, Nonogaki, Sueli, Chammas, Roger, Martins, Vilma R.

“…Cellular Prion Protein (PrPC) is a cell surface protein highly expressed in the nervous system, and to a lesser extent in other tissues. PrPC binds to the…”
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The interaction between prion protein and laminin modulates memory consolidation by Coitinho, Adriana S., Freitas, Adriana R. O., Lopes, Marilene H., Hajj, Glaucia N. M., Roesler, Rafael, Walz, Roger, Rossato, Janine I., Cammarota, Martin, Izquierdo, Ivan, Martins, Vilma R., Brentani, Ricardo R.

“…Cellular prion protein (PrPc) has a pivotal role in prion diseases. PrPc is a specific receptor for laminin (LN) γ1 peptide and several lines of evidence…”
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IMPACT Is a Developmentally Regulated Protein in Neurons That Opposes the Eukaryotic Initiation Factor 2α Kinase GCN2 in the modulation of Neurite Outgrowth by Roffé, Martín, Hajj, Glaucia N.M., Azevedo, Hátylas F., Alves, Viviane S., Castilho, Beatriz A.

“…The product of the mouse Imprinted and Ancient gene, IMPACT, is preferentially expressed in neurons. We have previously shown that IMPACT overexpression…”
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Stress‐inducible phosphoprotein 1 has unique cochaperone activity during development and regulates cellular response to ischemia via the prion protein by Beraldo, Flavio H., Soares, Iaci N., Goncalves, Daniela F., Fan, Jue, Thomas, Anu A., Santos, Tiago G., Mohammad, Amro H., Roffé, Martin, Calder, Michele D., Nikolova, Simona, Hajj, Glaucia N., Guimaraes, Andre L., Massensini, Andre R., Welch, Ian, Betts, Dean H., Gros, Robert, Drangova, Maria, Watson, Andrew J., Bartha, Robert, Prado, Vania F., Martins, Vilma R., Prado, Marco A. M.

“…Stress‐inducible phosphoprotein 1 (STI1) is part of the chaperone machinery, but it also functions as an extracellular ligand for the prion protein. However,…”
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Loss of prion protein is associated with the development of insulin resistance and obesity by de Brito, Giovanna, Lupinacci, Fernanda C, Beraldo, Flávio H, Santos, Tiago G, Roffé, Martín, Lopes, Marilene H, de Lima, Vladmir C, Martins, Vilma R, Hajj, Glaucia N

“…Prion protein (PrP ) was initially described due to its involvement in transmissible spongiform encephalopathies. It was subsequently demonstrated to be a cell…”
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