Search Results - "Hajishengallis, Evlambia"

Neutrophil homeostasis and inflammation: novel paradigms from studying periodontitis by Hajishengallis, George, Chavakis, Triantafyllos, Hajishengallis, Evlambia, Lambris, John D.

“…Review on dysregulation of neutrophil recruitment or function due to microbial or host‐related factors disrupting periodontal tissue homeostasis and causing…”
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Immune and regulatory functions of neutrophils in inflammatory bone loss by Hajishengallis, George, Moutsopoulos, Niki M, Hajishengallis, Evlambia, Chavakis, Triantafyllos

“…Highlights • Neutrophils are functionally versatile and perform hitherto unanticipated functions. • Neutrophil-associated pathology involves more than the…”
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Complement-Dependent Mechanisms and Interventions in Periodontal Disease by Hajishengallis, George, Kajikawa, Tetsuhiro, Hajishengallis, Evlambia, Maekawa, Tomoki, Reis, Edimara S, Mastellos, Dimitrios C, Yancopoulou, Despina, Hasturk, Hatice, Lambris, John D

“…Periodontitis is a prevalent inflammatory disease that leads to the destruction of the tooth-supporting tissues. Current therapies are not effective for all…”
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Genetic and intervention studies implicating complement C3 as a major target for the treatment of periodontitis by Maekawa, Tomoki, Abe, Toshiharu, Hajishengallis, Evlambia, Hosur, Kavita B, DeAngelis, Robert A, Ricklin, Daniel, Lambris, John D, Hajishengallis, George

“…Chronic periodontitis is induced by a dysbiotic microbiota and leads to inflammatory destruction of tooth-supporting connective tissue and bone. The third…”
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Physiologic root resorption in primary teeth: molecular and histological events by Harokopakis-Hajishengallis, Evlambia

“…Root resorption is a physiologic event for the primary teeth. It is still unclear whether odontoclasts, the cells which resorb the dental hard tissue, are…”
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Local complement-targeted intervention in periodontitis: proof-of-concept using a C5a receptor (CD88) antagonist by Abe, Toshiharu, Hosur, Kavita B, Hajishengallis, Evlambia, Reis, Edimara S, Ricklin, Daniel, Lambris, John D, Hajishengallis, George

“…When excessively activated or deregulated, complement becomes a major link between infection and inflammatory pathology including periodontitis. This oral…”
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Inhibition of pre-existing natural periodontitis in non-human primates by a locally administered peptide inhibitor of complement C3 by Maekawa, Tomoki, Briones, Ruel A., Resuello, Ranillo R.G., Tuplano, Joel V., Hajishengallis, Evlambia, Kajikawa, Tetsuhiro, Koutsogiannaki, Sophia, Garcia, Cristina A.G., Ricklin, Daniel, Lambris, John D., Hajishengallis, George

“…Aim Human periodontitis is associated with overactivation of complement, which is triggered by different mechanisms converging on C3, the central hub of the…”
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Milk fat globule epidermal growth factor 8 inhibits periodontitis in non‐human primates and its gingival crevicular fluid levels can differentiate periodontal health from disease in humans by Kajikawa, Tetsuhiro, Meshikhes, Fatimah, Maekawa, Tomoki, Hajishengallis, Evlambia, Hosur, Kavita B., Abe, Toshiharu, Moss, Kevin, Chavakis, Triantafyllos, Hajishengallis, George

“…Aim We have previously shown that the secreted glycoprotein milk fat globule epidermal growth factor 8 (MFG‐E8) has anti‐inflammatory and anti‐osteoclastogenic…”
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Multiple Idiopathic Cervical Root Resorption: A Challenge for a Transdisciplinary Medical-Dental Team by Chu, Emily Y, Deeb, Janina Golob, Foster, Brian L, Hajishengallis, Evlambia, Somerman, Martha J, Thumbigere-Math, Vivek

“…The goal of this perspective article is to use multiple idiopathic cervical root resorption (MICRR) as a model to demonstrate the need for transdisciplinary…”
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Safety and Efficacy of the Complement Inhibitor AMY-101 in a Natural Model of Periodontitis in Non-human Primates by Kajikawa, Tetsuhiro, Briones, Ruel A, Resuello, Ranillo R G, Tuplano, Joel V, Reis, Edimara S, Hajishengallis, Evlambia, Garcia, Cristina A G, Yancopoulou, Despina, Lambris, John D, Hajishengallis, George

“…Periodontitis is a chronic inflammatory disease associated with overactivation of the complement system. Recent preclinical studies suggest that…”
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Spatial mapping of polymicrobial communities reveals a precise biogeography associated with human dental caries by Kim, Dongyeop, Barraza, Juan P., Arthur, Rodrigo A., Hara, Anderson, Lewis, Karl, Liu, Yuan, Scisci, Elizabeth L., Hajishengallis, Evlambia, Whiteley, Marvin, Koo, Hyun

“…Tooth decay (dental caries) is a widespread human disease caused by microbial biofilms. Streptococcus mutans, a biofilm-former, has been consistently…”
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DEL-1 restrains osteoclastogenesis and inhibits inflammatory bone loss in nonhuman primates by Shin, Jieun, Maekawa, Tomoki, Abe, Toshiharu, Hajishengallis, Evlambia, Hosur, Kavita, Pyaram, Kalyani, Mitroulis, Ioannis, Chavakis, Triantafyllos, Hajishengallis, George

“…DEL-1 (developmental endothelial locus-1) is an endothelial cell-secreted protein that regulates LFA-1 (lymphocyte function-associated antigen-1)…”
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Candida albicans and Early Childhood Caries: A Systematic Review and Meta-Analysis by Xiao, Jin, Huang, Xuelian, Alkhers, Naemah, Alzamil, Hassan, Alzoubi, Sari, Wu, Tong Tong, Castillo, Daniel A, Campbell, Frank, Davis, Joseph, Herzog, Karli, Billings, Ronald, Kopycka-Kedzierawski, Dorota T, Hajishengallis, Evlambia, Koo, Hyun

“…Oral Candida albicans has been detected in children with early childhood caries (ECC) and has demonstrated cariogenic traits in animal models of the disease…”
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Advances in the microbial etiology and pathogenesis of early childhood caries by Hajishengallis, E., Parsaei, Y., Klein, M.I., Koo, H.

“…Summary Early childhood caries (ECC) is one of the most prevalent infectious diseases affecting children worldwide. ECC is an aggressive form of dental caries,…”
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Radiographic Diagnosis in the Pediatric Dental Patient by Jayaraman, Jayakumar, Hoikka, Angela, Cervantes Mendez, Maria Jose, Hajishengallis, Evlambia

“…This article emphasizes the selection criteria for radiographic acquisition in children due to the greater sensitivity of children for radiation compared with…”
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Complement Involvement in Periodontitis: Molecular Mechanisms and Rational Therapeutic Approaches by Hajishengallis, George, Maekawa, Tomoki, Abe, Toshiharu, Hajishengallis, Evlambia, Lambris, John D

“…The complement system is a network of interacting fluid-phase and cell surface-associated molecules that trigger, amplify, and regulate immune and inflammatory…”
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Role of complement in host–microbe homeostasis of the periodontium by Hajishengallis, George, Abe, Toshiharu, Maekawa, Tomoki, Hajishengallis, Evlambia, Lambris, John D

“…Highlights • Human periodontitis is associated with increased complement activation. • Periodontal bacteria evade and subvert complement. • Experimental…”
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Complement inhibition in pre-clinical models of periodontitis and prospects for clinical application by Hajishengallis, George, Hajishengallis, Evlambia, Kajikawa, Tetsuhiro, Wang, Baomei, Yancopoulou, Despina, Ricklin, Daniel, Lambris, John D

“…Highlights • Complement is overactivated in periodontitis, a dysbiotic oral inflammatory disease. • C3, C3a receptor, and C5a receptor 1 (CD88) mediate…”
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C3-targeted therapy in periodontal disease: moving closer to the clinic by Hajishengallis, George, Hasturk, Hatice, Lambris, John D., Apatzidou, Danae A., Belibasakis, Georgios N., Bostanci, Nagihan, Corby, Patricia M., Cutler, Christopher W., D’Aiuto, Francesco, Hajishengallis, Evlambia, Huber-Lang, Markus, Ioannidou, Effie, Kajikawa, Tetsuhiro, Kantarci, Alpdogan, Korostoff, Jonathan M., Kotsakis, Georgios A., Maekawa, Tomoki, Mastellos, Dimitrios C., Moutsopoulos, Niki M., Myneni, Srinivas, Nagelberg, Richard, Nilsson, Bo, Papapanou, Panos N., Papathanasiou, Evangelos, Potempa, Jan, Risitano, Antonio, Sahingur, S. Esra, Saito, Atsushi, Sculean, Anton, Stavropoulos, Andreas, Teles, Flavia R., Tonetti, Maurizio, Yancopoulou, Despina

“…Complement plays a key role in immunosurveillance and homeostasis. When dysregulated or overactivated, complement can become a pathological effector, as seen…”
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Oral literacy demand in the pediatric dental clinic: a pilot study by Benadof, Dafna, Hajishengallis, Evlambia, Cole, Amanda, Vidal, Carolina

“…Background The parent's ability to obtain, process, and understand important oral health information (i.e., their oral health literacy) is directly related to…”
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