Evaluation of the Relation between Salivary Beta-2 Microglobulin and Viral Proliferation in HBS Ag+, HBV DNA PCR super(+) and HBV DNA PCR super(-) Subjects

Background: Hepatitis includes a wide range of clinical and pathological conditions. The beta-2 microglobulin ( beta sub(2)M), as part of the HLA complex, is responsible for transmission of viral antigens on the surface of liver cells. The purpose of this study is to determine the concentration of s...

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Bibliographic Details
Published in:	Guvārish Vol. 17; no. 4; pp. 228 - 235
Main Authors:	Abdolsamadi, Hamid Reza, Eini, Peyman, Ronasi, Negin, Hajiluei, Mehrdad, Moghimbeigi, Abbas, Davoodi, Poorandokht, Ahmadi-Motamayel, Fatemeh
Format:	Journal Article
Language:	Persian
Published:	01-01-2013
Subjects:	Hepatitis B virus
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Summary:	Background: Hepatitis includes a wide range of clinical and pathological conditions. The beta-2 microglobulin ( beta sub(2)M), as part of the HLA complex, is responsible for transmission of viral antigens on the surface of liver cells. The purpose of this study is to determine the concentration of salivary beta sub(2)M as a marker of viral proliferation in subjects who are HbsAg super(+), HBV DNA PCR super(+) compared with those who are HbsAg super(+), HBV DNA PCR super(-). Materials and Methods: In this case-control study, we enrolled 25 patients who were Hbs Ag+, HBV DNA PCR super(+) in addition to 21 patients who were Hbs Ag+, HBV DNA PCR super(-). We obtained sputum samples from all patients and measured salivary beta sub(2)M levels by nephelometry. Data analyses were performed by the descriptive, student's t- and chi-square tests. Results: There were 25 men (54.3%) and 21 women (45.7%) with a mean age of 35.72+ or -11.86 years who participated. Of PCR super(+) patients, 72% were on medication, however 85.7% of the PCR- patients did not take medication (p<0.001). Salivary B sub(2)M concentration in the PCR super(+) patients (5.28+ or -5.45) was greater than observed in the PCR super(-) patients (1.51+ or -0.77), of which this difference was statistically significant (p<0.003). Conclusion: Salivary beta sub(2)M levels, as a marker of viral replication, could be used in patients with hepatitis B.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Feature-2
ISSN:	1560-7186 2008-756X