Search Results - "Hajicek, Nicole"

Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancer-associated mutations by Hajicek, Nicole, Keith, Nicholas C, Siraliev-Perez, Edhriz, Temple, Brenda Rs, Huang, Weigang, Zhang, Qisheng, Harden, T Kendall, Sondek, John

“…Direct activation of the human phospholipase C-γ isozymes (PLC-γ1, -γ2) by tyrosine phosphorylation is fundamental to the control of diverse biological…”
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Regulation and Physiological Functions of G12/13-Mediated Signaling Pathways by Suzuki, Nobuchika, Hajicek, Nicole, Kozasa, Tohru

“…Accumulating data indicate that G12 subfamily (Gα12/13)-mediated signaling pathways play pivotal roles in a variety of physiological processes, while aberrant…”
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Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G13 by Kozasa, Tohru, Hajicek, Nicole, Chow, Christina R., Suzuki, Nobuchika

“…G protein-mediated signal transduction can transduce signals from a large variety of extracellular stimuli into cells and is the most widely used mechanism for…”
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Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes by Siraliev-Perez, Edhriz, Stariha, Jordan T B, Hoffmann, Reece M, Temple, Brenda R S, Zhang, Qisheng, Hajicek, Nicole, Jenkins, Meredith L, Burke, John E, Sondek, John

“…Numerous receptor tyrosine kinases and immune receptors activate phospholipase C-γ (PLC-γ) isozymes at membranes to control diverse cellular processes…”
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Small Molecule Inhibitors of Phospholipase C from a Novel High-throughput Screen by Huang, Weigang, Barrett, Matthew, Hajicek, Nicole, Hicks, Stephanie, Harden, T. Kendall, Sondek, John, Zhang, Qisheng

“…Phospholipase C (PLC) isozymes are important signaling molecules, but few small molecule modulators are available to pharmacologically regulate their function…”
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Identification of Critical Residues in Gα13 for Stimulation of p115RhoGEF Activity and the Structure of the Gα13-p115RhoGEF Regulator of G Protein Signaling Homology (RH) Domain Complex by Hajicek, Nicole, Kukimoto-Niino, Mutsuko, Mishima-Tsumagari, Chiemi, Chow, Christina R., Shirouzu, Mikako, Terada, Takaho, Patel, Maulik, Yokoyama, Shigeyuki, Kozasa, Tohru

“…RH-RhoGEFs are a family of guanine nucleotide exchange factors that contain a regulator of G protein signaling homology (RH) domain. The heterotrimeric G…”
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Synthesis, characterization, and anti-melanoma activity of tetra-O-substituted analogs of nordihydroguaiaretic acid by Meyers, Ross O., Lambert, Joshua D., Hajicek, Nicole, Pourpak, Alan, Kalaitzis, John A., Dorr, Robert T.

“…Novel derivatives of nordihydoguaiaretic acid were synthesized and tested for in vitro and in vivo anticancer activity. Synthesis of seven semi-synthetic…”
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Dynamics of allosteric activation in PLC‐γ isozymes by Siraliev-Perez, Edhriz, Hoffmann, Reece, Stariha, Jordan, Hajicek, Nicole, Burke, John, Sondek, John

“…Abstract only The PLC‐γ isozymes (‐γ1, ‐γ2) hydrolyze the minor membrane phospholipid phosphatidylinositol 4,5‐bisphosphate (PIP 2 ) into the second messengers…”
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A membrane-associated, fluorogenic reporter for mammalian phospholipase C isozymes by Huang, Weigang, Wang, Xiaoyang, Endo-Streeter, Stuart, Barrett, Matthew, Waybright, Jarod, Wohlfeld, Christian, Hajicek, Nicole, Harden, T. Kendall, Sondek, John, Zhang, Qisheng

“…A diverse group of cell-surface receptors, including many G protein-coupled receptors and receptor tyrosine kinases, activate phospholipase C (PLC) isozymes to…”
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Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer’s disease by Tsai, Andy P., Dong, Chuanpeng, Lin, Peter Bor-Chian, Oblak, Adrian L., Viana Di Prisco, Gonzalo, Wang, Nian, Hajicek, Nicole, Carr, Adam J., Lendy, Emma K., Hahn, Oliver, Atkins, Micaiah, Foltz, Aulden G., Patel, Jheel, Xu, Guixiang, Moutinho, Miguel, Sondek, John, Zhang, Qisheng, Mesecar, Andrew D., Liu, Yunlong, Atwood, Brady K., Wyss-Coray, Tony, Nho, Kwangsik, Bissel, Stephanie J., Lamb, Bruce T., Landreth, Gary E.

“…Genetic association studies have demonstrated the critical involvement of the microglial immune response in Alzheimer’s disease (AD) pathogenesis…”
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A High-Throughput Assay to Identify Allosteric Inhibitors of the PLC‑γ Isozymes Operating at Membranes by Huang, Weigang, Carr, Adam J, Hajicek, Nicole, Sokolovski, Miri, Siraliev-Perez, Edhriz, Hardy, P. Brian, Pearce, Kenneth H, Sondek, John, Zhang, Qisheng

“…The two phospholipase C-γ (PLC-γ) isozymes are major signaling hubs and emerging therapeutic targets for various diseases, yet there are no selective…”
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Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C‑γ Isozymes by Hajicek, Nicole, Charpentier, Thomas H, Rush, Jeremy R, Harden, T. Kendall, Sondek, John

“…Multiple extracellular stimuli, such as growth factors and antigens, initiate signaling cascades through tyrosine phosphorylation and activation of…”
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Structural basis for the activation of PLC-[gamma] isozymes by phosphorylation and cancer-associated mutations by Hajicek, Nicole, Keith, Nicholas C, Siraliev-Perez, Edhriz, Temple, Brenda RS, Huang, Weigang, Zhang, Qisheng, Harden, T Kendall, Sondek, John

“…Direct activation of the human phospholipase C-[gamma] isozymes (PLC-[gamma]1, -[gamma]2) by tyrosine phosphorylation is fundamental to the control of diverse…”
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Auto-inhibition and phosphorylation-induced activation of PLC-γ isozymes by Hajicek, Nicole, Charpentier, Thomas H., Rush, Jeremy R., Harden, T. Kendall, Sondek, John

“…Multiple extracellular stimuli, such as growth factors and antigens, initiate signaling cascades through tyrosine phosphorylation and activation of…”
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Activation of Leukemia-associated RhoGEF by Gα13 with Significant Conformational Rearrangements in the Interface by Suzuki, Nobuchika, Tsumoto, Kouhei, Hajicek, Nicole, Daigo, Kenji, Tokita, Reiko, Minami, Shiro, Kodama, Tatsuhiko, Hamakubo, Takao, Kozasa, Tohru

“…The transient protein-protein interactions induced by guanine nucleotide-dependent conformational changes of G proteins play central roles in G protein-coupled…”
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Distinct regions of Gα13 participate in its regulatory interactions with RGS homology domain-containing RhoGEFs by Kreutz, Barry, Hajicek, Nicole, Yau, Douglas M., Nakamura, Susumu, Kozasa, Tohru

“…Gα12 and Gα13 transduce signals from G protein-coupled receptors to RhoA through RhoGEFs containing an RGS homology (RH) domain, such as p115 RhoGEF or…”
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Activation of Leukemia-associated RhoGEF by Gα13 with Significant Conformational Rearrangements in the InterfaceS by Suzuki, Nobuchika, Tsumoto, Kouhei, Hajicek, Nicole, Daigo, Kenji, Tokita, Reiko, Minami, Shiro, Kodama, Tatsuhiko, Hamakubo, Takao, Kozasa, Tohru

“…The transient protein-protein interactions induced by guanine nucleotide-dependent conformational changes of G proteins play central roles in G protein-coupled…”
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Activation of leukemia-associated RhoGEF by Galpha13 with significant conformational rearrangements in the interface by Suzuki, Nobuchika, Tsumoto, Kouhei, Hajicek, Nicole, Daigo, Kenji, Tokita, Reiko, Minami, Shiro, Kodama, Tatsuhiko, Hamakubo, Takao, Kozasa, Tohru

“…The transient protein-protein interactions induced by guanine nucleotide-dependent conformational changes of G proteins play central roles in G protein-coupled…”
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Activation of Leukemia-associated RhoGEF by G{alpha}13 with Significant Conformational Rearrangements in the Interface by Suzuki, Nobuchika, Tsumoto, Kouhei, Hajicek, Nicole, Daigo, Kenji, Tokita, Reiko, Minami, Shiro, Kodama, Tatsuhiko, Hamakubo, Takao, Kozasa, Tohru

“…The transient protein-protein interactions induced by guanine nucleotide-dependent conformational changes of G proteins play central roles in G protein-coupled…”
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Activation of Leukemia-associated RhoGEF by Gα13 with Significant Conformational Rearrangements in the Interface by Nobuchika Suzuki, Kouhei Tsumoto, Nicole Hajicek, Kenji Daigo, Reiko Tokita, Shiro Minami, Tatsuhiko Kodama, Takao Hamakubo, Tohru Kozasa

“…The transient protein-protein interactions induced by guanine nucleotide-dependent conformational changes of G proteins play central roles in G protein-coupled…”
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