Search Results - "Haj, Fawaz G"

(-)-Epicatechin improves insulin sensitivity in high fat diet-fed mice by Cremonini, Eleonora, Bettaieb, Ahmed, Haj, Fawaz G., Fraga, Cesar G., Oteiza, Patricia I.

“…Obesity constitutes a major public health concern, being frequently associated with type 2 diabetes (T2D). Evidence from studies in humans and experimental…”
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Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain by Inceoglu, Bora, Ahmed Bettaieb, Carlos A. Trindade da Silva, Kin Sing Stephen Lee, Fawaz G. Haj, Bruce D. Hammock

“…Despite intensive effort and resulting gains in understanding the mechanisms underlying neuropathic pain, limited success in therapeutic approaches have been…”
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(-)-Epicatechin protects the intestinal barrier from high fat diet-induced permeabilization: Implications for steatosis and insulin resistance by Cremonini, Eleonora, Wang, Ziwei, Bettaieb, Ahmed, Adamo, Ana M., Daveri, Elena, Mills, David A., Kalanetra, Karen M., Haj, Fawaz G., Karakas, Sidika, Oteiza, Patricia I.

“…Increased permeability of the intestinal barrier is proposed as an underlying factor for obesity-associated pathologies. Consumption of high fat diets (HFD) is…”
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Soluble Epoxide Hydrolase Deficiency or Inhibition Attenuates Diet-induced Endoplasmic Reticulum Stress in Liver and Adipose Tissue by Bettaieb, Ahmed, Nagata, Naoto, AbouBechara, Daniel, Chahed, Samah, Morisseau, Christophe, Hammock, Bruce D., Haj, Fawaz G.

“…Soluble epoxide hydrolase (sEH) is a cytosolic enzyme whose inhibition has beneficial effects in cardiovascular, inflammatory, and metabolic diseases in murine…”
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Modulation of mitochondrial dysfunction and endoplasmic reticulum stress are key mechanisms for the wide-ranging actions of epoxy fatty acids and soluble epoxide hydrolase inhibitors by Inceoglu, Bora, Bettaieb, Ahmed, Haj, Fawaz G., Gomes, Aldrin V., Hammock, Bruce D.

“…•The mechanism of action of epoxy fatty acids and inhibitors of the soluble epoxide hydrolase pivots on their ability to prevent mitochondrial dysfunction, to…”
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Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity by Lackey, Denise E, Lynch, Christopher J, Olson, Kristine C, Mostaedi, Rouzbeh, Ali, Mohamed, Smith, William H, Karpe, Fredrik, Humphreys, Sandy, Bedinger, Daniel H, Dunn, Tamara N, Thomas, Anthony P, Oort, Pieter J, Kieffer, Dorothy A, Amin, Rajesh, Bettaieb, Ahmed, Haj, Fawaz G, Permana, Paska, Anthony, Tracy G, Adams, Sean H

“…Elevated blood branched-chain amino acids (BCAA) are often associated with insulin resistance and type 2 diabetes, which might result from a reduced cellular…”
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The modulatory effects of alfalfa polysaccharide on intestinal microbiota and systemic health of Salmonella serotype (ser.) Enteritidis-challenged broilers by Li, Zemin, Zhang, Chongyu, Li, Bo, Zhang, Shimin, Haj, Fawaz G., Zhang, Guiguo, Lee, Yunkyoung

“…Salmonella serotype (ser.) Enteritidis infection in broilers is a main foodborne illness that substantially threatens food security. This study aimed to…”
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Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice by Harris, Todd R., Bettaieb, Ahmed, Kodani, Sean, Dong, Hua, Myers, Richard, Chiamvimonvat, Nipavan, Haj, Fawaz G., Hammock, Bruce D.

“…Liver fibrosis is a pathological condition in which chronic inflammation and changes to the extracellular matrix lead to alterations in hepatic tissue…”
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Laminaria japonica Extract Enhances Intestinal Barrier Function by Altering Inflammatory Response and Tight Junction-Related Protein in Lipopolysaccharide-Stimulated Caco-2 Cells by Yang, Hyo-Seon, Haj, Fawaz G, Lee, Myoungsook, Kang, Inhae, Zhang, Guiguo, Lee, Yunkyoung

“…In the normal physiological state, intestinal epithelial cells act as a defensive frontline of host mucosal immunity to tolerate constant exposure to external…”
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Atherosusceptible Shear Stress Activates Endoplasmic Reticulum Stress to Promote Endothelial Inflammation by Bailey, Keith A., Haj, Fawaz G., Simon, Scott I., Passerini, Anthony G.

“…Atherosclerosis impacts arteries where disturbed blood flow renders the endothelium susceptible to inflammation. Cytokine activation of endothelial cells (EC)…”
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Catechin and quercetin attenuate adipose inflammation in fructose‐fed rats and 3T3‐L1 adipocytes by Vazquez Prieto, Marcela A, Bettaieb, Ahmed, Rodriguez Lanzi, Cecilia, Soto, Verónica C, Perdicaro, Diahann J, Galmarini, Claudio R, Haj, Fawaz G, Miatello, Roberto M, Oteiza, Patricia I

“…SCOPE: This study evaluated the capacity of dietary catechin (C), quercetin (Q), and the combination of both (CQ), to attenuate adipose inflammation triggered…”
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Pharmacological inhibition of the Src homology phosphatase 2 confers partial protection in a mouse model of alcohol-associated liver disease by Hsu, Ming-Fo, Koike, Shinichiro, Chen, Chang-Shan, Najjar, Sonia M., Meng, Tzu-Ching, Haj, Fawaz G.

“…Alcohol-associated liver disease (ALD) is a leading factor of liver-related death worldwide. ALD has various manifestations that include steatosis, hepatitis,…”
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Hepatic protein-tyrosine phosphatase 1B disruption and pharmacological inhibition attenuate ethanol-induced oxidative stress and ameliorate alcoholic liver disease in mice by Hsu, Ming-Fo, Koike, Shinichiro, Mello, Aline, Nagy, Laura E., Haj, Fawaz G.

“…Alcoholic liver disease (ALD) is a major health problem and a significant cause of liver-related death. Currently, the mainstay for ALD therapy is alcohol…”
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Soluble epoxide hydrolase deficiency alters pancreatic islet size and improves glucose homeostasis in a model of insulin resistance by Luria, Ayala, Bettaieb, Ahmed, Xi, Yannan, Shieh, Guang-Jong, Liu, Hsin-Chen, Inoue, Hiromi, Tsai, Hsing-Ju, Imig, John D, Haj, Fawaz G, Hammock, Bruce D

“…Visceral obesity has been defined as an important element of the metabolic syndrome and contributes to the development of insulin resistance and cardiovascular…”
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Protein tyrosine phosphatase 1B deficiency in podocytes mitigates hyperglycemia-induced renal injury by Ito, Yoshihiro, Hsu, Ming-Fo, Bettaieb, Ahmed, Koike, Shinichiro, Mello, Aline, Calvo-Rubio, Miguel, Villalba, Jose M., Haj, Fawaz G.

“…Diabetic nephropathy is one of the most devastating complications of diabetes, and growing evidence implicates podocyte dysfunction in disease pathogenesis…”
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Protein tyrosine phosphatase Shp2 deficiency in podocytes attenuates lipopolysaccharide-induced proteinuria by Hsu, Ming-Fo, Bettaieb, Ahmed, Ito, Yoshihiro, Graham, James, Havel, Peter J., Haj, Fawaz G.

“…Podocytes are specialized epithelial cells that play a significant role in maintaining the integrity of the glomerular filtration barrier and preventing…”
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Acute augmentation of epoxygenated fatty acid levels rapidly reduces pain-related behavior in a rat model of type I diabetes by Inceoglu, Bora, Wagner, Karen M, Yang, Jun, Bettaieb, Ahmed, Schebb, Nils H, Hwang, Sung Hee, Morisseau, Christophe, Haj, Fawaz G, Hammock, Bruce D

“…The nerve damage occurring as a consequence of glucose toxicity in diabetes leads to neuropathic pain, among other problems. This pain dramatically reduces the…”
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Regulation of signaling at regions of cell-cell contact by endoplasmic reticulum-bound protein-tyrosine phosphatase 1B by Haj, Fawaz G, Sabet, Ola, Kinkhabwala, Ali, Wimmer-Kleikamp, Sabine, Roukos, Vassilis, Han, Hong-Mei, Grabenbauer, Markus, Bierbaum, Martin, Antony, Claude, Neel, Benjamin G, Bastiaens, Philippe I

“…Protein-tyrosine phosphatase 1B (PTP1B) is a ubiquitously expressed PTP that is anchored to the endoplasmic reticulum (ER). PTP1B dephosphorylates activated…”
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Subcutaneous administration of leptin normalizes fasting plasma glucose in obese type 2 diabetic UCD-T2DM rats by Cummings, Bethany P, Bettaieb, Ahmed, Graham, James L, Stanhope, Kimber L, Dill, Riva, Morton, Gregory J, Haj, Fawaz G, Havel, Peter J

“…Leptin has been shown to reduce hyperglycemia in rodent models of type 1 diabetes. We investigated the effects of leptin administration in University of…”
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Effects of soluble epoxide hydrolase deficiency on acute pancreatitis in mice by Bettaieb, Ahmed, Chahed, Samah, Tabet, George, Yang, Jun, Morisseau, Christophe, Griffey, Stephen, Hammock, Bruce D, Haj, Fawaz G

“…Acute pancreatitis (AP) is a frequent gastrointestinal disorder that causes significant morbidity, and its incidence has been progressively increasing. AP…”
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