Search Results - "Haj, Alicia J El"

Highly efficient delivery of functional cargoes by the synergistic effect of GAG binding motifs and cell-penetrating peptides by Dixon, James E., Osman, Gizem, Morris, Gavin E., Markides, Hareklea, Rotherham, Michael, Bayoussef, Zahia, Haj, Alicia J. El, Denning, Chris, Shakesheff, Kevin M.

“…Protein transduction domains (PTDs) are powerful nongenetic tools that allow intracellular delivery of conjugated cargoes to modify cell behavior. Their use in…”
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Enhanced chondrogenic potential in GelMA-based 3D cartilage model via Wnt3a surface immobilization by Imere, Angela, Foster, Nicola C., Hajiali, Hadi, Okur, Kerime Ebrar, Wright, Abigail L., Barroso, Ines A., Haj, Alicia J. El

“…Cartilage tissue engineering aims to develop functional substitutes for treating cartilage defects and osteoarthritis. Traditional two-dimensional (2D) cell…”
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Receptor-targeted, magneto-mechanical stimulation of osteogenic differentiation of human bone marrow-derived mesenchymal stem cells by Hu, Bin, El Haj, Alicia J, Dobson, Jon

“…Mechanical cues are employed to promote stem cell differentiation and functional tissue formation in tissue engineering and regenerative medicine. We have…”
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Remote triggering of TGF-β/Smad2/3 signaling in human adipose stem cells laden on magnetic scaffolds synergistically promotes tenogenic commitment by Matos, Ana M., Gonçalves, Ana I., Rodrigues, Márcia T., Miranda, Margarida S., Haj, Alicia J. El, Reis, Rui L., Gomes, Manuela E.

“…Injuries affecting load bearing tendon tissues are a significant clinical burden and efficient treatments are still unmet. Tackling tendon regeneration, tissue…”
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Magnetic ion channel activation of TREK1 in human mesenchymal stem cells using nanoparticles promotes osteogenesis in surrounding cells by Henstock, James R, Rotherham, Michael, El Haj, Alicia J

“…Magnetic ion channel activation technology uses superparamagnetic nanoparticles conjugated with targeting antibodies to apply mechanical force directly to…”
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Control of scar tissue formation in the cornea: strategies in clinical and corneal tissue engineering by Wilson, Samantha L, El Haj, Alicia J, Yang, Ying

“…Corneal structure is highly organized and unified in architecture with structural and functional integration which mediates transparency and vision. Disease…”
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Tissue engineering for tendon repair by Bagnaninchi, Pierre-Olivier, Yang, Ying, El Haj, Alicia J, Maffulli, Nicola

“…Tissue engineering aims to induce tissue self-regeneration in vivo or to produce a functional tissue replacement in vitro to be then implanted in the body. To…”
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Wnt-modified materials mediate asymmetric stem cell division to direct human osteogenic tissue formation for bone repair by Okuchi, Yoshihisa, Reeves, Joshua, Ng, Soon Seng, Doro, Daniel H., Junyent, Sergi, Liu, Karen J., El Haj, Alicia J., Habib, Shukry J.

“…The maintenance of human skeletal stem cells (hSSCs) and their progeny in bone defects is a major challenge. Here, we report on a transplantable bandage…”
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Immobilized WNT Proteins Act as a Stem Cell Niche for Tissue Engineering by Lowndes, Molly, Rotherham, Michael, Price, Joshua C., El Haj, Alicia J., Habib, Shukry J.

“…The timing, location, and level of WNT signaling are highly regulated during embryonic development and for the maintenance of adult tissues. Consequently the…”
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Remotely Actuated Magnetic Nanocarpets for Bone Tissue Engineering: Non‐Invasive Modulation of Mechanosensitive Ion Channels for Enhanced Osteogenesis by Unnithan, Afeesh Rajan, Sasikala, Arathyram Ramachandra Kurup, Shrestha, Bishnu Kumar, Lincoln, Alex, Thomson, Thomas, El Haj, Alicia J.

“…Non‐invasive approaches using remotely controllable nanomaterials have demonstrated their potential ability to enhance treatment efficacy in regenerative…”
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Therapeutic Benefit for Late, but Not Early, Passage Mesenchymal Stem Cells on Pain Behaviour in an Animal Model of Osteoarthritis by El Haj, Alicia, Kehoe, Oksana, Kay, Alasdair, Mapp, Paul, Burston, James J., Xu, Luting, Sagar, Devi Rani, Markides, Hareklea, Chapman, Victoria, Morris, Robert H.

“…Background. Mesenchymal stem cells (MSCs) have a therapeutic potential for the treatment of osteoarthritic (OA) joint pathology and pain. The aims of this…”
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Remote activation of the Wnt/β-catenin signalling pathway using functionalised magnetic particles by Rotherham, Michael, El Haj, Alicia J

“…Wnt signalling pathways play crucial roles in developmental biology, stem cell fate and tissue patterning and have become an attractive therapeutic target in…”
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Gelatin-Based Materials in Ocular Tissue Engineering by Rose, James B, Pacelli, Settimio, Haj, Alicia J El, Dua, Harminder S, Hopkinson, Andrew, White, Lisa J, Rose, Felicity R A J

“…Gelatin has been used for many years in pharmaceutical formulation, cell culture and tissue engineering on account of its excellent biocompatibility, ease of…”
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Magnetic Ion Channel Activation (MICA)-Enabled Screening Assay: A Dynamic Platform for Remote Activation of Mechanosensitive Ion Channels by Unnithan, Afeesh Rajan, Rotherham, Michael, Markides, Hareklea, El Haj, Alicia J

“…This study reports results of a mechanical platform-based screening assay (MICA) to evaluate the remote activation of mechanosensitive ion channels. Here, we…”
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Two-Dimensional and Three-Dimensional Cartilage Model Platforms for Drug Evaluation and High-Throughput Screening Assays by Foster, Nicola C, Hall, Nicole M, Haj, Alicia J El

“…Osteoarthritis (OA) is a severely painful and debilitating disease of the joint, which brings about degradation of the articular cartilage and currently has…”
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Remote Activation of Mechanotransduction via Integrin Alpha-5 via Aptamer-Conjugated Magnetic Nanoparticles Promotes Osteogenesis by Hajiali, Hadi, Rotherham, Michael, El Haj, Alicia J

“…Bone regeneration and repair are complex processes in the adult skeleton, and current research has focused on understanding and controlling these processes…”
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Hydrostatic pressure stimulates the osteogenesis and angiogenesis of MSCs/HUVECs co-culture on porous PLGA scaffolds by Shen, Hong-Xian, Liu, Jing-Zhi, Yan, Xiao-Qing, Yang, Hong-Ning, Hu, Shu-Qun, Yan, Xian-Liang, Xu, Tie, El Haj, Alicia J., Yang, Ying, Lü, Lan-Xin

“…In native bone tissue regeneration, blood vessels, providing oxygen and nutrition for tissues, can promote the regeneration of bone and accelerate the repair…”
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Immobilization of Wnt Fragment Peptides on Magnetic Nanoparticles or Synthetic Surfaces Regulate Wnt Signaling Kinetics by Hu, Bin, Rotherham, Michael, Farrow, Neil, Roach, Paul, Dobson, Jon, El Haj, Alicia J

“…Wnt signaling plays an important role in embryogenesis and adult stem cell homeostasis. Its diminished activation is implicated in osteoporosis and…”
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Tenogenic Differentiation of Human Embryonic Stem Cells by Dale, Tina P, Mazher, Shazia, Webb, William R, Zhou, Jing, Maffulli, Nicola, Chen, Guo-Qiang, El Haj, Alicia J, Forsyth, Nicholas R

“…Tendon healing is complex to manage because of the limited regeneration capacity of tendon tissue; stem cell-based tissue engineering approaches may provide…”
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Selective activation of mechanosensitive ion channels using magnetic particles by Hughes, Steven, McBain, Stuart, Dobson, Jon, El Haj, Alicia J

“…This study reports the preliminary development of a novel magnetic particle-based technique that permits the application of highly localized mechanical forces…”
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