Search Results - "Hait, W N"

Silencing of stathmin induces tumor-suppressor function in breast cancer cell lines harboring mutant p53 by ALLI, E, YANG, J.-M, HAIT, W. N

“…Cancers harboring dominant-negative p53 mutations are often aggressive and difficult to treat. Direct attempts to restore wild-type p53 function have produced…”
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Activity and regulation by growth factors of calmodulin-dependent protein kinase III (elongation factor 2-kinase) in human breast cancer by PARMER, T. G, WARD, M. D, YURKOW, E. J, VYAS, V. H, KEARNEY, T. J, HAIT, W. N

“…Calmodulin-dependent protein kinase III (CaM kinase III, elongation factor-2 kinase) is a unique member of the Ca2+/CaM-dependent protein kinase family…”
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The expression of drug resistance gene products during the progression of human prostate cancer by SULLIVAN, G. F, AMENTA, P. S, VILLANUEVA, J. D, ALVAREZ, C. J, YANG, J.-M, HAIT, W. N

“…Prostate cancer progresses from a localized disease to a widely disseminated malignancy. Each step along this progression pathway involves multiple genetic…”
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Activation of phospholipase C induces the expression of the multidrug resistance (MDR1) gene through the Raf-MAPK pathway by Yang, J M, Vassil, A D, Hait, W N

“…Resistance to multiple, unrelated cancer chemotherapeutic drugs can be mediated by P-glycoprotein, the MDR1 gene product. Numerous substances, including…”
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The role of MAP4 expression in the sensitivity to paclitaxel and resistance to vinca alkaloids in p53 mutant cells by ZHANG, C. C, YANG, J.-M, WHITE, E, MURPHY, M, LEVINE, A, HAIT, W. N

“…Mutations in p53 change the sensitivity to cancer chemotherapeutic drugs. Whereas many drugs, including the vinca alkaloids, often become less effective when…”
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Phase I Clinical and Pharmacologic Study of 13-cis-Retinoic Acid, Interferon Alfa, and Paclitaxel in Patients With Prostate Cancer and Other Advanced Malignancies by DIPAOLA, R. S, RAFI, M. M, ZHANG, C, WHITE, E, GUPTA, E, HAIT, W. N, VYOS, V, TOPPMEYER, D, RUBIN, E, PATEL, J, GOODIN, S, MEDINA, M, MEDINA, P, ZAMEK, R

“…Recent studies demonstrate that retinoids decrease expression of the anti-apoptotic protein bcl-2, enhance the effect of chemotherapy, and act synergistically…”
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Structural features determining activity of phenothiazines and related drugs for inhibition of cell growth and reversal of multidrug resistance by Ford, J M, Prozialeck, W C, Hait, W N

“…Phenothiazines and structurally related compounds inhibit cellular proliferation and sensitize multidrug-resistant (MDR) cells to chemotherapeutic agents. To…”
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DNA damage increases sensitivity to Vinca alkaloids and decreases sensitivity to taxanes through p53-dependent repression of microtubule-associated protein 4 by ZHANG, C. C, YANG, J.-M, BASH-BABULA, J, WHITE, E, MURPHY, M, LEVINE, A. J, HAIT, W. N

“…Taxanes and Vinca alkaloids are among the most active classes of drugs in the treatment of cancer. Yet, fewer than 50% of previously untreated patients…”
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The Prognostic and Predictive Values of ECD-HER-2 by HAIT, William N

“…The search for a simple, sensitive test to reliably determine prognosis and predict response to therapy in patients with cancer is an important area of…”
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Calmodulin: a potential target for cancer chemotherapeutic agents by Hait, W N, Lazo, J S

“…Calmodulin is a ubiquitous, calcium-binding protein that is responsible for many of the intracellular actions of calcium. Recent evidence suggests that…”
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Effect of anti-calmodulin drugs on the growth and sensitivity of C6 rat glioma cells to bleomycin by Hait, W N, Gesmonde, J F, Lazo, J S

“…Antipsychotic drugs that bind to and inhibit the action of calmodulin also inhibit cellular proliferation. In addition these drugs are cytotoxic to most…”
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Biochemical correlates of the antitumor and antimitochondrial properties of gossypol enantiomers by Benz, C C, Keniry, M A, Ford, J M, Townsend, A J, Cox, F W, Palayoor, S, Matlin, S A, Hait, W N, Cowan, K H

“…Racemic gossypol has been shown to have antitumor properties that may be due to its ability to uncouple tumor mitochondria or to its inhibitory effects on a…”
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Cellular and biochemical characterization of thioxanthenes for reversal of multidrug resistance in human and murine cell lines by FORD, J. M, BRUGGEMANN, E. P, PASTAN, I, GOTTESMAN, M. M, HAIT, W. N

“…We have previously shown that phenothiazines sensitize multidrug resistant (MDR) cells to chemotherapeutic drugs in a manner related to specific structural…”
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Disruption of the EF-2 kinase/Hsp90 protein complex : A possible mechanism to inhibit glioblastoma by geldanamycin by JUN YANG, YANG, Jin-Ming, IANNONE, Marie, WEICHUNG JOE SHIH, YONG LIN, HAIT, William N

“…Glioblastoma multiforme is the most treatment-resistant brain tumor. Elongation factor-2 (EF-2) kinase (calmodulin kinase III) is a unique protein kinase that…”
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Pharmacology of drugs that alter multidrug resistance in cancer by Ford, J M, Hait, W N

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Clinical and Biologic Activity of an Estrogenic Herbal Combination (PC-SPES) in Prostate Cancer by DiPaola, Robert S, Zhang, Huayan, Lambert, George H, Meeker, Robert, Licitra, Edward, Rafi, Mohamed M, Zhu, Bao Ting, Spaulding, Heidi, Goodin, Susan, Toledano, Michel B, Hait, William N, Gallo, Michael A

“…Herbal therapies are unconventional treatments in wide use for many diseases. They are sold as nutritional supplements for numerous illnesses, including the…”
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Structure-activity relationships of phenothiazines and related drugs for inhibition of protein kinase C by Aftab, D T, Ballas, L M, Loomis, C R, Hait, W N

“…Phenothiazines are known to inhibit the activity of protein kinase C. To identify structural features that determine inhibitory activity against the enzyme, we…”
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Modulation of resistance to alkylating agents in cancer cell by gossypol enantiomers by Ford, J M, Hait, W N, Matlin, S A, Benz, C C

“…Several cell lines resistant to alkylating agents possess increased activity of glutathione-S-transferase (GST) drug detoxifying enzymes. Inhibition of certain…”
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Sensitivity of K562 human chronic myelogenous leukemia blast cells transfected with a human multidrug resistance cDNA to cytotoxic drugs and differentiating agents by HAIT, W. N, CHOUDHURY, S, SRINIVASAN SRIMATKANDADA, MURREN, J. R

“…The blast crisis of chronic myelogenous leukemia (CML) is refractory to most forms of cancer chemotherapy, but may be amenable to drugs that differentiate…”
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Terfenadine (Seldane): a new drug for restoring sensitivity to multidrug resistant cancer cells by Hait, W N, Gesmonde, J F, Murren, J R, Yang, J M, Chen, H X, Reiss, M

“…In our efforts to identify clinically effective drugs for reversing multidrug resistance (MDR) mediated by P-glycoprotein, we tested terfenadine for anti-MDR…”
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