Search Results - "Hair, Pamela"

Inhibition of complement activation, myeloperoxidase, NET formation and oxidant activity by PIC1 peptide variants by Hair, Pamela S, Enos, Adrianne I, Krishna, Neel K, Cunnion, Kenji M

“…A product of rational molecular design, PA-dPEG24 is the lead derivative of the PIC1 family of peptides with multiple functional abilities including classical…”
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Classical complement pathway inhibition reduces brain damage in a hypoxic ischemic encephalopathy animal model by Kumar, Parvathi, Hair, Pamela, Cunnion, Kenji, Krishna, Neel, Bass, Thomas

“…Perinatal hypoxic ischemic encephalopathy (HIE) remains a major contributor of infant death and long-term disability worldwide. The role played by the…”
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Complement effectors, C5a and C3a, in cystic fibrosis lung fluid correlate with disease severity by Hair, Pamela S, Sass, Laura A, Vazifedan, Turaj, Shah, Tushar A, Krishna, Neel K, Cunnion, Kenji M

“…In cystic fibrosis (CF), lung damage is mediated by a cycle of obstruction, infection, inflammation and tissue destruction. The complement system is a major…”
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Peptide inhibition of acute lung injury in a novel two-hit rat model by Sampson, Alana C, Lassiter, Brittany P, Gregory Rivera, Magdielis, Hair, Pamela S, Jackson, Kaitlyn G, Enos, Adrianne I, Vazifedan, Turaj, Werner, Alice L, Glesby, Marshall J, Lattanzio, Frank A, Cunnion, Kenji M, Krishna, Neel K

“…Acute lung injury (ALI) often causes severe trauma that may progress to significant morbidity and mortality. ALI results from a combination of the underlying…”
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Staphylococcus aureus surface protein SdrE binds complement regulator factor H as an immune evasion tactic by Sharp, Julia A, Echague, Charlene G, Hair, Pamela S, Ward, Michael D, Nyalwidhe, Julius O, Geoghegan, Joan A, Foster, Timothy J, Cunnion, Kenji M

“…Similar to other highly successful invasive bacterial pathogens, Staphylococcus aureus recruits the complement regulatory protein factor H (fH) to its surface…”
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Inhibition of Myeloperoxidase Activity in Cystic Fibrosis Sputum by Peptide Inhibitor of Complement C1 (PIC1) by Hair, Pamela S, Sass, Laura A, Krishna, Neel K, Cunnion, Kenji M

“…Myeloperoxidase is the major peroxidase enzyme in neutrophil granules and implicated in contributing to inflammatory lung damage in cystic fibrosis. Free…”
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Inhibition of Immune Complex Complement Activation and Neutrophil Extracellular Trap Formation by Peptide Inhibitor of Complement C1 by Hair, Pamela S, Enos, Adrianne I, Krishna, Neel K, Cunnion, Kenji M

“…Two major aspects of systemic lupus erythematosus (SLE) pathogenesis that have yet to be targeted therapeutically are immune complex-initiated complement…”
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Peptide Inhibitor of Complement C1 (PIC1) demonstrates antioxidant activity via single electron transport (SET) and hydrogen atom transfer (HAT) by Gregory Rivera, Magdielis, Hair, Pamela S, Cunnion, Kenji M, Krishna, Neel K

“…Reactive oxygen species (ROS) are natural byproducts of oxidative respiration that are toxic to organs and tissues. To mitigate ROS damage, organisms have…”
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Incompatible erythrocyte transfusion with lipopolysaccharide induces acute lung injury in a novel rat model by Gregory Rivera, Magdielis, Sampson, Alana C, Hair, Pamela S, Pallera, Haree K, Jackson, Kaitlyn G, Enos, Adrianne I, Vazifedan, Turaj, Werner, Alice L, Goldberg, Corinne L, Lattanzio, Frank A, Cunnion, Kenji M, Krishna, Neel K

“…Acute transfusion reactions can manifest in many forms including acute hemolytic transfusion reaction, allergic reaction and transfusion-related acute lung…”
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Complement Effectors of Inflammation in Cystic Fibrosis Lung Fluid Correlate with Clinical Measures of Disease by Sass, Laura A, Hair, Pamela S, Perkins, Amy M, Shah, Tushar A, Krishna, Neel K, Cunnion, Kenji M

“…In cystic fibrosis (CF), lung damage is mediated by a cycle of obstruction, infection, and inflammation. Here we explored complement inflammatory effectors in…”
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Complement Activation and STAT4 Expression Are Associated with Early Inflammation in Diabetic Wounds by Cunnion, Kenji M, Krishna, Neel K, Pallera, Haree K, Pineros-Fernandez, Angela, Rivera, Magdielis Gregory, Hair, Pamela S, Lassiter, Brittany P, Huyck, Ryan, Clements, Mary A, Hood, Antoinette F, Rodeheaver, George T, Cottler, Patrick S, Nadler, Jerry L, Dobrian, Anca D

“…Diabetic non-healing wounds are a major clinical problem. The mechanisms leading to poor wound healing in diabetes are multifactorial but unresolved…”
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Peptide inhibition of neutrophil-mediated injury after in vivo challenge with supernatant of Pseudomonas aeruginosa and immune-complexes by Enos, Adrianne, Kumar, Parvathi, Lassiter, Brittany, Sampson, Alana, Hair, Pamela, Krishna, Neel, Cunnion, Kenji

“…Neutrophils are recognized for their role in host defense against pathogens as well as inflammatory conditions mediated through many mechanisms including…”
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A complement-mediated rat xenotransfusion model of platelet refractoriness by Enos, Adrianne I., Hair, Pamela S., Krishna, Neel K., Cunnion, Kenji M.

“…•Decreased platelet viability after sensitization and incubation with sera is inhibited Peptide Inhibitor of Complement C1.•Wistar rat sera decreases human…”
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Peptide Inhibitor of Complement C1 (PIC1) Rapidly Inhibits Complement Activation after Intravascular Injection in Rats by Sharp, Julia A, Hair, Pamela S, Pallera, Haree K, Kumar, Parvathi S, Mauriello, Clifford T, Nyalwidhe, Julius O, Phelps, Cody A, Park, Dalnam, Thielens, Nicole M, Pascal, Stephen M, Chen, Waldon, Duffy, Diane M, Lattanzio, Frank A, Cunnion, Kenji M, Krishna, Neel K

“…The complement system has been increasingly recognized to play a pivotal role in a variety of inflammatory and autoimmune diseases. Consequently, therapeutic…”
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Peptide Inhibitor of Complement C1, RLS-0071, Reduces Zosteriform Spread of Herpes Simplex Virus Type 1 Skin Infection and Promotes Survival in Infected Mice by Bhutta, Maimoona S, Sausen, Daniel G, Reed, Kirstin M, Gallo, Elisa S, Hair, Pamela S, Lassiter, Brittany P, Krishna, Neel K, Cunnion, Kenji M, Borenstein, Ronen

“…Herpes simplex virus type 1 (HSV-1) is a prevalent human pathogen primarily transmitted through skin-to-skin contact, especially on and around mucosal surfaces…”
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Hyperglycemic conditions inhibit C3-mediated immunologic control of Staphylococcus aureus by Hair, Pamela S, Echague, Charlene G, Rohn, Reuben D, Krishna, Neel K, Nyalwidhe, Julius O, Cunnion, Kenji M

“…Diabetic patients are at increased risk for bacterial infections; these studies provide new insight into the role of the host defense complement system in…”
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Therapeutic hypothermia modulates complement factor C3a and C5a levels in a rat model of hypoxic ischemic encephalopathy by Shah, Tushar A., Nejad, Jasmine E., Pallera, Haree K., Lattanzio, Frank A., Farhat, Rawad, Kumar, Parvathi S., Hair, Pamela S., Bass, W. Thomas, Krishna, Neel K.

“…Background: Therapeutic hypothermia (HT) is the only intervention that improves outcomes in neonatal hypoxic-ischemic encephalopathy (HIE). However, the…”
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Clumping Factor A Interaction with Complement Factor I Increases C3b Cleavage on the Bacterial Surface of Staphylococcus aureus and Decreases Complement-Mediated Phagocytosis by Hair, Pamela S, Echague, Charlene G, Sholl, Amber M, Watkins, Justin A, Geoghegan, Joan A, Foster, Timothy J, Cunnion, Kenji M

“…The human complement system is important in the immunological control of Staphylococcus aureus infection. We showed previously that S. aureus surface protein…”
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Classical complement activation on human erythrocytes in subjects with systemic lupus erythematosus and a history of autoimmune hemolytic anemia by Hair, Pamela, Goldman, Daniel W, Li, Jessica, Petri, Michelle, Krishna, Neel, Cunnion, Kenji

“…Introduction Autoimmune hemolytic anemia (AIHA) is a serious manifestation of systemic lupus erythematosus (SLE) associated with significant morbidity and…”
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Staphylococcus aureus Clumping Factor A Binds to Complement Regulator Factor I and Increases Factor I Cleavage of C3b by Hair, Pamela S., Ward, Michael D., Semmes, O. John, Foster, Timothy J., Cunnion, Kenji M.

“…The human complement system plays an important role in the control of Staphylococcus aureus infection. For instance, we previously demonstrated that the…”
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