Search Results - "Hains, B"

Molecular mechanisms of stress-induced prefrontal cortical impairment : Implications for mental illness by HAINS, Avis B, ARNSTEN, Amy F. T

“…The symptoms of mental illness often involve weakened regulation of thought, emotion, and behavior by the prefrontal cortex. Exposure to stress exacerbates…”
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A Phase 1 study of GDC‐0134, a dual leucine zipper kinase inhibitor, in ALS by Katz, Jonathan S., Rothstein, Jeffrey D., Cudkowicz, Merit E., Genge, Angela, Oskarsson, Björn, Hains, Avis B., Chen, Chen, Galanter, Joshua, Burgess, Braydon L., Cho, William, Kerchner, Geoffrey A., Yeh, Felix L., Ghosh, Arundhati Sengupta, Cheeti, Sravanthi, Brooks, Logan, Honigberg, Lee, Couch, Jessica A., Rothenberg, Michael E., Brunstein, Flavia, Sharma, Khema R., Berg, Leonard, Berry, James D., Glass, Jonathan D.

“…Objective Dual leucine zipper kinase (DLK), which regulates the c‐Jun N‐terminal kinase pathway involved in axon degeneration and apoptosis following neuronal…”
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Altered Sodium Channel Expression in Second-Order Spinal Sensory Neurons Contributes to Pain after Peripheral Nerve Injury by Hains, Bryan C, Saab, Carl Y, Klein, Joshua P, Craner, Matthew J, Waxman, Stephen G

“…Peripheral nerve injury is known to upregulate the rapidly repriming Na(v)1.3 sodium channel within first-order spinal sensory neurons. In this study, we…”
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Serotonergic neural precursor cell grafts attenuate bilateral hyperexcitability of dorsal horn neurons after spinal hemisection in rat by Hains, B.C, Johnson, K.M, Eaton, M.J, Willis, W.D, Hulsebosch, C.E

“…Hemisection of the rat spinal cord at thoracic level 13 provides a model of spinal cord injury that is characterized by chronic pain attributable to…”
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Mechanisms of chronic central neuropathic pain after spinal cord injury by Hulsebosch, Claire E, Hains, Bryan C, Crown, Eric D, Carlton, Susan M

“…Abstract Not all spinal contusions result in mechanical allodynia, in which non-noxious stimuli become noxious. The studies presented use the NYU impactor at…”
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Reduction of pathological and behavioral deficits following spinal cord contusion injury with the selective cyclooxygenase-2 inhibitor NS-398 by Hains, B C, Yucra, J A, Hulsebosch, C E

“…Spinal cord injury (SCI) results in loss of locomotor function and development of abnormal chronic pain syndromes (mechanical allodynia, thermal hyperalgesia)…”
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Activated Microglia Contribute to the Maintenance of Chronic Pain after Spinal Cord Injury by Hains, Bryan C, Waxman, Stephen G

“…Traumatic spinal cord injury (SCI) results not only in motor impairment but also in chronic central pain, which can be refractory to conventional treatment…”
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Primary cortical motor neurons undergo apoptosis after axotomizing spinal cord injury by Hains, Bryan C., Black, Joel A., Waxman, Stephen G.

“…Spinal cord injury (SCI) results in loss of voluntary motor control followed by incomplete recovery, which is partly mediated by the descending corticospinal…”
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Engraftment of Serotonergic Precursors Enhances Locomotor Function and Attenuates Chronic Central Pain Behavior Following Spinal Hemisection Injury in the Rat by Hains, Bryan C., Johnson, Kathia M., McAdoo, David J., Eaton, Mary J., Hulsebosch, Claire E.

“…Spinal cord injury (SCI) results in abnormal locomotor and pain syndromes in humans. T13 spinal hemisection in the rat results in development of permanent…”
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Transplants of Adrenal Medullary Chromaffin Cells Reduce Forelimb and Hindlimb Allodynia in a Rodent Model of Chronic Central Pain after Spinal Cord Hemisection Injury by Hains, Bryan C., Chastain, Kathy M., Everhart, Alex W., McAdoo, David J., Hulsebosch, Claire E.

“…In the majority of patients, spinal cord injury (SCI) results in abnormal pain syndromes in which nonnoxious stimuli become noxious (allodynia). To reduce…”
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Neuropathic Pain Memory Is Maintained by Rac1-Regulated Dendritic Spine Remodeling after Spinal Cord Injury by Tan, Andrew M, Stamboulian, Severine, Chang, Yu-Wen, Zhao, Peng, Hains, Avis B, Waxman, Stephen G, Hains, Bryan C

“…Localized increases in synaptic strength constitute a synaptic basis for learning and memory in the CNS and may also contribute to the maintenance of…”
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Strain and model differences in behavioral outcomes after spinal cord injury in rat by Mills, C D, Hains, B C, Johnson, K M, Hulsebosch, C E

“…Spinal cord injury (SCI) results in loss of function below the level of injury and the development of chronic central pain (CCP) syndromes. Since different…”
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Temporal plasticity of dorsal horn somatosensory neurons after acute and chronic spinal cord hemisection in rat by Hains, Bryan C., Willis, William D., Hulsebosch, Claire E.

“…Unilateral T13 hemisection of the rat spinal cord produces a model of chronic spinal cord injury (SCI) that is characterized by bilateral hyperexcitability of…”
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Subdural engraftment of serotonergic neurons following spinal hemisection restores spinal serotonin, downregulates serotonin transporter, and increases BDNF tissue content in rat by Hains, Bryan C, Fullwood, Steven D, Eaton, Mary J, Hulsebosch, Claire E

“…Spinal hemisection injury at T13 results in development of permanent mechanical allodynia and thermal hyperalgesia due to interruption and subsequent loss of…”
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Bridging the gap: from discovery to clinical trials in spinal cord injury by Hulsebosch, C E, Hains, B C, Waldrep, K, Young, W

“…Recently, the Kent Waldrep National Paralysis Foundation initiated a think tank intended to bridge several gaps and achieve several goals in regard to spinal…”
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Locomotor recovery and mechanical hyperalgesia following spinal cord injury depend on age at time of injury in rat by Gwak, Young Seob, Hains, Bryan C., Johnson, Kathia M., Hulsebosch, Claire E.

“…We tested the effect of age at the time of spinal cord injury (SCI) on locomotor recovery, in open field tests, and mechanical hyperalgesia, using paw…”
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Changes in Serotonin, Serotonin Transporter Expression and Serotonin Denervation Supersensitivity: Involvement in Chronic Central Pain after Spinal Hemisection in the Rat by Hains, Bryan C., Everhart, Alex W., Fullwood, Steven D., Hulsebosch, Claire E.

“…Spinal cord injury (SCI) results in abnormal locomotor and pain syndromes in humans. In a rodent SCI model, T13 unilateral spinal hemisection results in…”
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Long-term protection of central axons with phenytoin in monophasic and chronic-relapsing EAE by Black, Joel A., Liu, Shujun, Hains, Bryan C., Saab, Carl Y., Waxman, Stephen G.

“…Axonal degeneration is a major contributor to non-remitting deficits in multiple sclerosis, and there is thus considerable current interest in the development…”
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Remote neuroimmune signaling: a long-range mechanism of nociceptive network plasticity by Saab, Carl Y, Hains, Bryan C

“…Chronic pain secondary to neuronal injury is actively and continuously modulated at multiple locations along the sensory neuraxis. Here, we describe how…”
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Early microglial inhibition preemptively mitigates chronic pain development after experimental spinal cord injury by Tan, Andrew M, Zhao, Peng, Waxman, Stephen G, Hains, Bryan C

“…Spinal cord injury (SCI) results in the development of chronic pain syndromes that can persist indefinitely and cause reductions in quality of life. Treatment…”
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