Search Results - "Hainaut, Pierre"

A global view of hepatocellular carcinoma: trends, risk, prevention and management by Yang, Ju Dong, Hainaut, Pierre, Gores, Gregory J., Amadou, Amina, Plymoth, Amelie, Roberts, Lewis R.

“…Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-related death worldwide. Risk factors for HCC include chronic hepatitis B and…”
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Revisiting tumor patterns and penetrance in germline TP53 mutation carriers: temporal phases of Li–Fraumeni syndrome by Amadou, Amina, Waddington Achatz, Maria I, Hainaut, Pierre

“…PURPOSE OF REVIEWGermline pathogenic TP53 mutation may predispose to multiple cancers but penetrance and cancer patterns remain incompletely documented. We…”
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Massively regulated genes: the example of TP53 by Hollstein, Monica, Hainaut, Pierre

“…Intensive study of the TP53 gene over the last three decades has revealed a highly complex network of factors that regulate its performance. The gene has…”
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Genetics of lung-cancer susceptibility by Brennan, Paul, Dr, Hainaut, Pierre, PhD, Boffetta, Paolo, MD

“…Summary Lung cancer is the most common form of cancer death worldwide. Although reduction of tobacco consumption remains the most appropriate strategy to…”
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Expression of p53 N-terminal isoforms in B-cell precursor acute lymphoblastic leukemia and its correlation with clinicopathological profiles by Oh, Lixian, Hainaut, Pierre, Blanchet, Sandrine, Ariffin, Hany

“…TP53 mutations occur in only about 3% of primary and 10-20% of relapse B-cell precursor acute lymphoblastic leukaemia (BCP-ALL). However, alternative…”
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The TP53 Database: transition from the International Agency for Research on Cancer to the US National Cancer Institute by de Andrade, Kelvin César, Lee, Elaine E., Tookmanian, Elise M., Kesserwan, Chimene A., Manfredi, James J., Hatton, Jessica N., Loukissas, Jennifer K., Zavadil, Jiri, Zhou, Lei, Olivier, Magali, Frone, Megan N., Shahzada, Owais, Longabaugh, William J. R., Kratz, Christian P., Malkin, David, Hainaut, Pierre, Savage, Sharon A.

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Identification of osteopontin as a novel marker for early hepatocellular carcinoma by Shang, Sufen, Plymoth, Amelie, Ge, Shaokui, Feng, Ziding, Rosen, Hugo R., Sangrajrang, Suleeporn, Hainaut, Pierre, Marrero, Jorge A., Beretta, Laura

“…The aim of this study was to identify a biomarker that could improve alpha‐fetoprotein (AFP) performance in hepatocellular carcinoma (HCC) surveillance among…”
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Genetic and epigenetic alterations as biomarkers for cancer detection, diagnosis and prognosis by Herceg, Zdenko, Hainaut, Pierre

“…The development of cancer is driven by the accumulation of scores of alterations affecting the structure and function of the genome. Equally important in this…”
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Ectopic activation of germline and placental genes identifies aggressive metastasis-prone lung cancers by Rousseaux, Sophie, Debernardi, Alexandra, Jacquiau, Baptiste, Vitte, Anne-Laure, Vesin, Aurélien, Nagy-Mignotte, Hélène, Moro-Sibilot, Denis, Brichon, Pierre-Yves, Lantuejoul, Sylvie, Hainaut, Pierre, Laffaire, Julien, de Reyniès, Aurélien, Beer, David G, Timsit, Jean-François, Brambilla, Christian, Brambilla, Elisabeth, Khochbin, Saadi

“…Activation of normally silent tissue-specific genes and the resulting cell "identity crisis" are the unexplored consequences of malignant epigenetic…”
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Circulating free DNA in plasma or serum as biomarker of carcinogenesis: Practical aspects and biological significance by Gormally, Emmanuelle, Caboux, Elodie, Vineis, Paolo, Hainaut, Pierre

“…The presence of small amounts of tumor DNA in cell free DNA (CFDNA) circulating in the plasma or serum of cancer patients was first demonstrated 30 years ago…”
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The aflatoxin-induced TP53 mutation at codon 249 ( R249S ): Biomarker of exposure, early detection and target for therapy by Gouas, Doriane, Shi, Hong, Hainaut, Pierre

“…Abstract Hepatocellular Carcinoma (HCC) in high-incidence areas (sub-Saharan Africa, South-Eastern Asia) often contains a somatic mutation at codon 249 in TP53…”
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Redox control and interplay between p53 isoforms: roles in the regulation of basal p53 levels, cell fate, and senescence by Hafsi, Hind, Hainaut, Pierre

“…The p53 tumor suppressor protein has achieved stardom in molecular oncology owing to frequent inactivation in a large range of cancers. Known as a factor…”
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Pooled Analysis of the Prognostic and Predictive Effects of KRAS Mutation Status and KRAS Mutation Subtype in Early-Stage Resected Non–Small-Cell Lung Cancer in Four Trials of Adjuvant Chemotherapy by SHEPHERD, Frances A, DOMERG, Caroline, BOURREDJEM, abderrahmane, LE TEUFF, Gwénaël, PIRKER, Robert, FILIPITS, Martin, ROSELL, Rafael, KRATZKE, Robert, BANDARCHI, Bizhan, XIAOLI MA, CAPELLETTI, Marzia, SORIA, Jean-Charles, HAINAUT, Pierre, TSAO, Ming-Sound, JÄNNE, Pasi A, PIGNON, Jean-Pierre, GRAZIANO, Stephen, DOUILLARD, Jean-Yves, BRAMBILLA, Elizabeth, LE CHEVALIER, Thierry, SEYMOUR, Lesley

“…We undertook this analysis of KRAS mutation in four trials of adjuvant chemotherapy (ACT) versus observation (OBS) to clarify the prognostic/predictive roles…”
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Natural variations of copper and sulfur stable isotopes in blood of hepatocellular carcinoma patients by Balter, Vincent, da Costa, Andre Nogueira, Bondanese, Victor Paky, Jaouen, Klervia, Lamboux, Aline, Sangrajrang, Suleeporn, Vincent, Nicolas, Fourel, François, Télouk, Philippe, Gigou, Michelle, Lécuyer, Christophe, Srivatanakul, Petcharin, Bréchot, Christian, Albarède, Francis, Hainaut, Pierre

“…Significance In cancer, the metabolism of copper and sulfur are dysregulated, leading to deleterious side effects. These issues are commonly addressed by…”
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PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain by Lambert, Jeremy M.R., Gorzov, Petr, Veprintsev, Dimitry B., Söderqvist, Maja, Segerbäck, Dan, Bergman, Jan, Fersht, Alan R., Hainaut, Pierre, Wiman, Klas G., Bykov, Vladimir J.N.

“…Restoration of wild-type p53 expression triggers cell death and eliminates tumors in vivo. The identification of mutant p53-reactivating small molecules such…”
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Role of Obesity in the Risk of Breast Cancer: Lessons from Anthropometry by Amadou, Amina, Hainaut, Pierre, Romieu, Isabelle

“…An estimated 1.38 million new cases of breast cancer (BC) are diagnosed each year in women worldwide. Of these, the majority are categorized as invasive ductal…”
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Hepatitis B virus impairs TLR9 expression and function in plasmacytoid dendritic cells by Vincent, Isabelle E, Zannetti, Claudia, Lucifora, Julie, Norder, Helene, Protzer, Ulrike, Hainaut, Pierre, Zoulim, Fabien, Tommasino, Massimo, Trépo, Christian, Hasan, Uzma, Chemin, Isabelle

“…Plasmacytoid dendritic cells (pDCs) play a key role in detecting pathogens by producing large amounts of type I interferon (IFN) by sensing the presence of…”
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Targeted deep sequencing of plasma circulating cell-free DNA reveals Vimentin and Fibulin 1 as potential epigenetic biomarkers for hepatocellular carcinoma by Holmila, Reetta, Sklias, Athena, Muller, David C, Degli Esposti, Davide, Guilloreau, Paule, Mckay, James, Sangrajrang, Suleeporn, Srivatanakul, Petcharin, Hainaut, Pierre, Merle, Philippe, Herceg, Zdenko, Nogueira da Costa, Andre

“…Hepatocellular carcinoma (HCC) is the second most common cause of cancer death worldwide, but is still lacking sensitive and specific biomarkers for early…”
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Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer by Reynoird, Nicolas, Mazur, Pawel K, Stellfeld, Timo, Flores, Natasha M, Lofgren, Shane M, Carlson, Scott M, Brambilla, Elisabeth, Hainaut, Pierre, Kaznowska, Ewa B, Arrowsmith, Cheryl H, Khatri, Purvesh, Stresemann, Carlo, Gozani, Or, Sage, Julien

“…Pancreatic ductal adenocarcinoma (PDAC) is a lethal form of cancer with few therapeutic options. We found that levels of the lysine methyltransferase SMYD2…”
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Roles of thioredoxin reductase 1 and APE Ref-1 in the control of basal p53 stability and activity by SEEMANN, Séverine, HAINAUT, Pierre

“…The p53 protein is redox-sensitive in vitro but in vivo effectors of this sensitivity are not known. In yeasts deficient for thioredoxin (Trx) reductase (TRR),…”
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