Bilobalide inhibits the expression of aquaporin 1, 4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia

The present results demonstrated that in an adult rat model of permanent middle cerebral artery occlusion （pMCAO）, pretreatment with bilobalide reduced brain water content and infarct area, down-regulated aquaporin 1, 4 mRNA expression in brain edema tissue, then inhibited their synthesis in the str...

Full description

Saved in:

Bibliographic Details
Published in:	中国神经再生研究（英文版） Vol. 6; no. 27; pp. 2105 - 2111
Main Author:	Haiming Qin Fulin Song Hongguang Han Hong Ou Xingwen Zhai Bin Qin Song You
Format:	Journal Article
Language:	English
Published:	School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning Province, China Department of Pathology, General Hospital of Shenyang Military Area Command of Chinese PLA, Shenyang 110016, Liaoning Province, Chin%Department of Pathology, General Hospital of Shenyang Military Area Command of Chinese PLA, Shenyang 110016, Liaoning Province, China%School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning Province, China 25-09-2011
Subjects:	mRNA表达局灶性脑缺血成年大鼠水通道蛋白永久性白果胶质纤维酸性蛋白脑组织含水量 brain edema bilobalide neural regeneration permanent middle cerebral artery occlusion aquaporin glial fibrillary acidic protein
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The present results demonstrated that in an adult rat model of permanent middle cerebral artery occlusion （pMCAO）, pretreatment with bilobalide reduced brain water content and infarct area, down-regulated aquaporin 1, 4 mRNA expression in brain edema tissue, then inhibited their synthesis in the striatum, in particular at the early stage of ischemia （at 8 hours after pMCAO）, inhibited glial fibrillary acidic protein expression, and lightened reactive gliosis. These data sug-gest that bilobalide attenuates brain edema formation due to reduced expression of aquaporins.
Bibliography:	bilobalide aquaporin brain edema permanent middle cerebral artery occlusion glial fibrillary acidic protein neural regeneration The present results demonstrated that in an adult rat model of permanent middle cerebral artery occlusion （pMCAO）, pretreatment with bilobalide reduced brain water content and infarct area, down-regulated aquaporin 1, 4 mRNA expression in brain edema tissue, then inhibited their synthesis in the striatum, in particular at the early stage of ischemia （at 8 hours after pMCAO）, inhibited glial fibrillary acidic protein expression, and lightened reactive gliosis. These data sug-gest that bilobalide attenuates brain edema formation due to reduced expression of aquaporins. 11-5422/R
ISSN:	1673-5374
DOI:	10.3969/j.issn.1673-5374.2011.27.004