Search Results - "Haigwood, Nancy L"

Use of broadly neutralizing antibodies for HIV‐1 prevention by Pegu, Amarendra, Hessell, Ann J., Mascola, John R., Haigwood, Nancy L.

“…Summary Antibodies have a long history in antiviral therapy, but until recently, they have not been actively pursued for HIV‐1 due to modest potency and…”
Get full text

Passive and active antibody studies in primates to inform HIV vaccines by Hessell, Ann J, Malherbe, Delphine C, Haigwood, Nancy L

“…Prevention of infection remains the ultimate goal for HIV vaccination, and there is compelling evidence that antibodies directed to Envelope are necessary to…”
Get full text

Improved delivery of broadly neutralizing antibodies by nanocapsules suppresses SHIV infection in the CNS of infant rhesus macaques by Wen, Jing, Cheever, Tracy, Wang, Lan, Wu, Di, Reed, Jason, Mascola, John, Chen, Xuejun, Liu, Cuiping, Pegu, Amarendra, Sacha, Jonah B, Lu, Yunfeng, Haigwood, Nancy L, Chen, Irvin S. Y

“…Broadly neutralizing antibodies (bNAbs) directed to HIV-1 have shown promise at suppressing viremia in animal models. However, the use of bNAbs for the central…”
Get full text

Phagocytosis by an HIV antibody is associated with reduced viremia irrespective of enhanced complement lysis by Spencer, David A., Goldberg, Benjamin S., Pandey, Shilpi, Ordonez, Tracy, Dufloo, Jérémy, Barnette, Philip, Sutton, William F., Henderson, Heidi, Agnor, Rebecca, Gao, Lina, Bruel, Timothée, Schwartz, Olivier, Haigwood, Nancy L., Ackerman, Margaret E., Hessell, Ann J.

“…Increasingly, antibodies are being used to treat and prevent viral infections. In the context of HIV, efficacy is primarily attributed to dose-dependent…”
Get full text

Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity by Shapiro, Mariya B., Cheever, Tracy, Malherbe, Delphine C., Pandey, Shilpi, Reed, Jason, Yang, Eun Sung, Wang, Keyun, Pegu, Amarendra, Chen, Xuejun, Siess, Don, Burke, David, Henderson, Heidi, Lewinsohn, Rebecca, Fischer, Miranda, Stanton, Jeffrey J., Axthelm, Michael K., Kahl, Christoph, Park, Byung, Lewis, Anne D., Sacha, Jonah B., Mascola, John R., Hessell, Ann J., Haigwood, Nancy L.

“…Vertical transmission accounts for most human immunodeficiency virus (HIV) infection in children, and treatments for newborns are needed to abrogate infection…”
Get full text

Differential V2-directed antibody responses in non-human primates infected with SHIVs or immunized with diverse HIV vaccines by Weiss, Svenja, Itri, Vincenza, Pan, Ruimin, Jiang, Xunqing, Luo, Christina C., Morris, Lynn, Malherbe, Delphine C., Barnette, Philip, Alexander, Jeff, Kong, Xiang-Peng, Haigwood, Nancy L., Hessell, Ann J., Duerr, Ralf, Zolla-Pazner, Susan

“…V2p and V2i antibodies (Abs) that are specific for epitopes in the V1V2 region of the HIV gp120 envelope (Env) do not effectively neutralize HIV but mediate…”
Get full text

Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques by Burwitz, Benjamin J., Wettengel, Jochen M., Mück-Häusl, Martin A., Ringelhan, Marc, Ko, Chunkyu, Festag, Marvin M., Hammond, Katherine B., Northrup, Mina, Bimber, Benjamin N., Jacob, Thomas, Reed, Jason S., Norris, Reed, Park, Byung, Moller-Tank, Sven, Esser, Knud, Greene, Justin M., Wu, Helen L., Abdulhaqq, Shaheed, Webb, Gabriela, Sutton, William F., Klug, Alex, Swanson, Tonya, Legasse, Alfred W., Vu, Tania Q., Asokan, Aravind, Haigwood, Nancy L., Protzer, Ulrike, Sacha, Jonah B.

“…Hepatitis B virus (HBV) is a major global health concern, and the development of curative therapeutics is urgently needed. Such efforts are impeded by the lack…”
Get full text

Advancing HIV Broadly Neutralizing Antibodies: From Discovery to the Clinic by Spencer, David A., Shapiro, Mariya B., Haigwood, Nancy L., Hessell, Ann J.

“…Despite substantial progress in confronting the global HIV-1 epidemic since its inception in the 1980s, better approaches for both treatment and prevention…”
Get full text

Passive neutralizing antibody controls SHIV viremia and enhances B cell responses in infant macaques by Haigwood, Nancy L, Ng, Cherie T, Jaworski, J Pablo, Jayaraman, Pushpa, Sutton, William F, Delio, Patrick, Kuller, LaRene, Anderson, David, Landucci, Gary, Richardson, Barbra A, Burton, Dennis R, Forthal, Donald N

“…Maternal HIV-1-specific antibodies are efficiently transferred to newborns, but their role in disease control is unknown. We administered neutralizing IgG,…”
Get full text

Functional Antibody Response Against V1V2 and V3 of HIV gp120 in the VAX003 and VAX004 Vaccine Trials by Balasubramanian, Preetha, Williams, Constance, Shapiro, Mariya B., Sinangil, Faruk, Higgins, Keith, Nádas, Arthur, Totrov, Maxim, Kong, Xiang-Peng, Fiore-Gartland, Andrew J., Haigwood, Nancy L., Zolla-Pazner, Susan, Hioe, Catarina E.

“…Immunization with HIV AIDSVAX gp120 vaccines in the phase III VAX003 and VAX004 trials did not confer protection. To understand the shortcomings in antibody…”
Get full text

Sequential Immunization with a Subtype B HIV-1 Envelope Quasispecies Partially Mimics the In Vivo Development of Neutralizing Antibodies by MALHERBE, Delphine C, DORIA-ROSE, Nicole A, BARNETT, Susan, STAMATATOS, Leonidas, HAIGWOOD, Nancy L, MISHER, Lynda, BECKETT, Travis, BLAY PURYEAR, Wendy, SCHUMAN, Jason T, KRAFT, Zane, O'MALLEY, Jean, MORI, Motomi, SRIVASTAVA, Indresh

“…OA  Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+…”
Get full text

Polyfunctional Tier 2-Neutralizing Antibodies Cloned following HIV-1 Env Macaque Immunization Mirror Native Antibodies in a Human Donor by Spencer, David A, Malherbe, Delphine C, Vázquez Bernat, Néstor, Ádori, Monika, Goldberg, Benjamin, Dambrauskas, Nicholas, Henderson, Heidi, Pandey, Shilpi, Cheever, Tracy, Barnette, Philip, Sutton, William F, Ackerman, Margaret E, Kobie, James J, Sather, D Noah, Karlsson Hedestam, Gunilla B, Haigwood, Nancy L, Hessell, Ann J

“…Vaccine efforts to combat HIV are challenged by the global diversity of viral strains and shielding of neutralization epitopes on the viral envelope…”
Get full text

Evidence for the Role of a Second Fc-Binding Receptor in Placental IgG Transfer in Nonhuman Primates by Rosenberg, Yvonne J, Ordonez, Tracy, Khanwalkar, Urjeet S, Barnette, Philip, Pandey, Shilpi, Backes, Iara M, Otero, Claire E, Goldberg, Benjamin S, Crowley, Andrew R, Leib, David A, Shapiro, Mariya B, Jiang, Xiaoming, Urban, Lori A, Lees, Jonathan, Hessell, Ann J, Permar, Sallie, Haigwood, Nancy L, Ackerman, Margaret E

“…Transplacental transfer of maternal antibodies provides the fetus and newborn with passive protection against infectious diseases. While the role of the highly…”
Get full text

Multimeric scaffolds displaying the HIV-1 envelope MPER induce MPER-specific antibodies and cross-neutralizing antibodies when co-immunized with gp160 DNA by Krebs, Shelly J, McBurney, Sean P, Kovarik, Dina N, Waddell, Chelsea D, Jaworski, J Pablo, Sutton, William F, Gomes, Michelle M, Trovato, Maria, Waagmeester, Garret, Barnett, Susan J, DeBerardinis, Piergiuseppe, Haigwood, Nancy L

“…Developing a vaccine that overcomes the diversity of HIV-1 is likely to require a strategy that directs antibody (Ab) responses toward conserved regions of the…”
Get full text

Continuous Viral Escape and Selection by Autologous Neutralizing Antibodies in Drug-Naïve Human Immunodeficiency Virus Controllers by MAHALANABIS, Madhumita, JAYARAMAN, Pushpa, MIURA, Toshiyuki, PEREYRA, Florencia, CHESTER, E. Michael, RICHARDSON, Barbra, WALKER, Bruce, HAIGWOOD, Nancy L

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Induction of neutralizing antibodies in rhesus macaques using V3 mimotope peptides by Hessell, Ann J, McBurney, Sean, Pandey, Shilpi, Sutton, William, Liu, Lily, Li, Liuzhe, Totrov, Maxim, Zolla-Pazner, Susan, Haigwood, Nancy L, Gorny, Miroslaw K

“…Abstract RV144 vaccinees with low HIV-1 Envelope-specific IgA antibodies (Abs) also had Abs directed to the hypervariable region 3 (V3) that inversely…”
Get full text

Increased breadth of HIV-1 neutralization achieved by diverse antibody clones each with limited neutralization breadth by Chukwuma, Valentine U, Kose, Nurgun, Sather, D Noah, Sapparapu, Gopal, Falk, Rachel, King, Hannah, Singh, Vidisha, Lampley, Rebecca, Malherbe, Delphine C, Ditto, Noah T, Sullivan, Jonathan T, Barnes, Trevor, Doranz, Benjamin J, Labranche, Celia C, Montefiori, David C, Kalams, Spyros A, Haigwood, Nancy L, Crowe, Jr, James E

“…Broadly neutralizing antibodies (bNAbs) are rarely elicited by current human immunodeficiency virus type 1 (HIV-1) vaccine designs, but the presence of bNAbs…”
Get full text

Rapid Induction of Multifunctional Antibodies in Rabbits and Macaques by Clade C HIV-1 CAP257 Envelopes Circulating During Epitope-Specific Neutralization Breadth Development by Malherbe, Delphine C, Wibmer, Constantinos Kurt, Nonyane, Molati, Reed, Jason, Sather, D Noah, Spencer, David A, Schuman, Jason T, Guo, Biwei, Pandey, Shilpi, Robins, Harlan, Park, Byung, Fuller, Deborah H, Sacha, Jonah B, Moore, Penny L, Hessell, Ann J, Haigwood, Nancy L

“…We report here on HIV-1 immunization results in rabbits and macaques co-immunized with clade C gp160 DNA and gp140 trimeric envelope vaccines, a strategy…”
Get full text

CD4+ T Cells Are Dispensable for Induction of Broad Heterologous HIV Neutralizing Antibodies in Rhesus Macaques by Sarkar, Sanghita, Spencer, David A, Barnette, Philip, Pandey, Shilpi, Sutton, William F, Basu, Madhubanti, Burch, Reuben E, Cleveland, John D, Rosenberg, Alexander F, Rangel-Moreno, Javier, Keefer, Michael C, Hessell, Ann J, Haigwood, Nancy L, Kobie, James J

“…Induction of broadly neutralizing antibodies (bNAbs) is a major goal for HIV vaccine development. HIV envelope glycoprotein (Env)-specific bNAbs isolated from…”
Get full text

High Specific Infectivity of Plasma Virus from the Pre-Ramp-Up and Ramp-Up Stages of Acute Simian Immunodeficiency Virus Infection by MA, Zhong-Min, STONE, Mars, PIATAK, Mike, SCHWEIGHARDT, Becky, HAIGWOOD, Nancy L, MONTEFIORI, David, LIFSON, Jeffrey D, BUSCH, Michael P, MILLER, Christopher J

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text