Search Results - "Haigh, Cathryn"

Prion propagation and cellular dysfunction in prion disease: Disconnecting the dots by Foliaki, Simote T, Haigh, Cathryn L

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Sodium hypochlorite inactivation of human CJD prions by Groveman, Bradley R, Race, Brent, Hughson, Andrew G, Haigh, Cathryn L

“…Prion diseases are transmissible, fatal neurologic diseases of mammals caused by the accumulation of mis-folded, disease associated prion protein (PrPd)…”
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Altered energy metabolism in Fatal Familial Insomnia cerebral organoids is associated with astrogliosis and neuronal dysfunction by Foliaki, Simote T, Smith, Anna, Schwarz, Benjamin, Bohrnsen, Eric, Bosio, Catharine M, Williams, Katie, Orrú, Christina D, Lachenauer, Hailey, Groveman, Bradley R, Haigh, Cathryn L

“…Fatal familial insomnia (FFI) is a rare neurodegenerative disease caused by a dominantly inherited single amino acid substitution (D178N) within the prion…”
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Organoids for modeling prion diseases by Walters, Ryan O., Haigh, Cathryn L.

“…Human cerebral organoids are an exciting and novel model system emerging in the field of neurobiology. Cerebral organoids are spheres of self-organizing,…”
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Cerebral organoids as a new model for prion disease by Groveman, Bradley R, Smith, Anna, Williams, Katie, Haigh, Cathryn L

“…Human brain has proven difficult to model, and this tissue is not widely available for study. [...]the application of organoid technology to produce 3D…”
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Stress and viral insults do not trigger E200K PrP conversion in human cerebral organoids by Smith, Anna, Groveman, Bradley R, Winkler, Clayton, Williams, Katie, Walters, Ryan, Yuan, Jue, Zou, Wenquan, Peterson, Karin, Foliaki, Simote T, Haigh, Cathryn L

“…Prion diseases are a group of rare, transmissible, and invariably fatal neurodegenerative diseases that affect both humans and animals. The cause of these…”
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α-Synuclein seeding activity in duodenum biopsies from Parkinson's disease patients by Vascellari, Sarah, Orrù, Christina D, Groveman, Bradley R, Parveen, Sabiha, Fenu, Giuseppe, Pisano, Giada, Piga, Giuseppe, Serra, Giulia, Oppo, Valentina, Murgia, Daniela, Perra, Andrea, Angius, Fabrizio, Hughson, Andrew G, Haigh, Cathryn L, Manzin, Aldo, Cossu, Giovanni, Caughey, Byron

“…Abnormal deposition of α-synuclein is a key feature and biomarker of Parkinson's disease. α-Synuclein aggregates can propagate themselves by a prion-like…”
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Reduced SOD2 expression does not influence prion disease course or pathology in mice by Foliaki, Simote T, Race, Brent, Williams, Katie, Baune, Chase, Groveman, Bradley R, Haigh, Cathryn L

“…Prion diseases are progressive, neurodegenerative diseases affecting humans and animals. Also known as the transmissible spongiform encephalopathies, for the…”
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Human cerebral organoids as a therapeutic drug screening model for Creutzfeldt–Jakob disease by Groveman, Bradley R., Ferreira, Natalia C., Foliaki, Simote T., Walters, Ryan O., Winkler, Clayton W., Race, Brent, Hughson, Andrew G., Zanusso, Gianluigi, Haigh, Cathryn L.

“…Creutzfeldt–Jakob Disease (CJD) is a fatal, currently incurable, neurodegenerative disease. The search for candidate treatments would be greatly facilitated by…”
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A 3D cell culture approach for studying neuroinflammation by Carroll, James A., Foliaki, Simote T., Haigh, Cathryn L.

“…[Display omitted] •Methodology for generating murine 3D integrated co-cultures of neural lineage cells and microglia.•Integrated microglia assume a ramified…”
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Lack of Transmission of Chronic Wasting Disease Prions to Human Cerebral Organoids by Groveman, Bradley R, Williams, Katie, Race, Brent, Foliaki, Simote, Thomas, Tina, Hughson, Andrew G, Walters, Ryan O, Zou, Wenquan, Haigh, Cathryn L

“…Chronic wasting disease (CWD) is a cervid prion disease with unknown zoonotic potential that might pose a risk to humans who are exposed. To assess the…”
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Cellular Analysis of Adult Neural Stem Cells for Investigating Prion Biology by Haigh, Cathryn L

“…Traditional primary and secondary cell cultures have been used for the investigation of prion biology and disease for many years. While both types of cultures…”
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A Functional Role for A[beta] in Metal Homeostasis? N-Truncation and High-Affinity Copper Binding by Mital, Mariusz, Wezynfeld, Nina E, Frczyk, Tomasz, Wiloch, Magdalena Z, Wawrzyniak, Urszula E, Bonna, Arkadiusz, Tumpach, Carolin, Barnham, Kevin J, Haigh, Cathryn L, Bal, Wojciech, Drew, Simon C

“…Accumulation of the [beta]-amyloid (A[beta]) peptide in extracellular senile plaques rich in copper and zinc is a defining pathological feature of Alzheimer's…”
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A PrP EGFR signaling axis controls neural stem cell senescence through modulating cellular energy pathways by Groveman, Bradley R., Schwarz, Benjamin, Bohrnsen, Eric, Foliaki, Simote T., Carroll, James A., Wood, Aleksandar R., Bosio, Catharine M., Haigh, Cathryn L.

“…Mis-folding of the prion protein (PrP) is known to cause neurodegenerative disease; however, the native function of this protein remains poorly defined. PrP…”
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The Prion Protein N1 and N2 Cleavage Fragments Bind to Phosphatidylserine and Phosphatidic Acid; Relevance to Stress-Protection Responses by Haigh, Cathryn L, Tumpach, Carolin, Drew, Simon C, Collins, Steven J

“…Internal cleavage of the cellular prion protein generates two well characterised N-terminal fragments, N1 and N2. These fragments have been shown to bind to…”
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Sporadic Creutzfeldt-Jakob disease prion infection of human cerebral organoids by Groveman, Bradley R, Foliaki, Simote T, Orru, Christina D, Zanusso, Gianluigi, Carroll, James A, Race, Brent, Haigh, Cathryn L

“…For the transmissible, neurogenerative family of prion diseases, few human models of infection exist and none represent structured neuronal tissue. Human…”
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Using our mini-brains: cerebral organoids as an improved cellular model for human prion disease by Groveman, Bradley, Walters, Ryan, Haigh, Cathryn

“…The most common form of human prion disease is sporadic Creutzfeldt-Jakob disease (CJD), occurring in 1–2 people per million per year. Progression of prion…”
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Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases by Song, Feizhi, Kovac, Valerija, Mohammadi, Behnam, Littau, Jessica L., Scharfenberg, Franka, Matamoros Angles, Andreu, Vanni, Ilaria, Shafiq, Mohsin, Orge, Leonor, Galliciotti, Giovanna, Djakkani, Salma, Linsenmeier, Luise, Černilec, Maja, Hartman, Katrina, Jung, Sebastian, Tatzelt, Jörg, Neumann, Julia E., Damme, Markus, Tschirner, Sarah K., Lichtenthaler, Stefan F., Ricklefs, Franz L., Sauvigny, Thomas, Schmitz, Matthias, Zerr, Inga, Puig, Berta, Tolosa, Eva, Ferrer, Isidro, Magnus, Tim, Rupnik, Marjan S., Sepulveda-Falla, Diego, Matschke, Jakob, Šmid, Lojze M., Bresjanac, Mara, Andreoletti, Olivier, Krasemann, Susanne, Foliaki, Simote T., Nonno, Romolo, Becker-Pauly, Christoph, Monzo, Cecile, Crozet, Carole, Haigh, Cathryn L., Glatzel, Markus, Curin Serbec, Vladka, Altmeppen, Hermann C.

“…Proteolytic cell surface release (‘shedding’) of the prion protein (PrP), a broadly expressed GPI-anchored glycoprotein, by the metalloprotease ADAM10 impacts…”
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Prion protein cleavage fragments regulate adult neural stem cell quiescence through redox modulation of mitochondrial fission and SOD2 expression by Collins, Steven J., Tumpach, Carolin, Groveman, Bradley R., Drew, Simon C., Haigh, Cathryn L.

“…Neurogenesis continues in the post-developmental brain throughout life. The ability to stimulate the production of new neurones requires both quiescent and…”
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Hereditary E200K mutation within the prion protein gene alters human iPSC derived cardiomyocyte function by Wood, Aleksandar R., Foliaki, Simote T., Groveman, Bradley R., Walters, Ryan O., Williams, Katie, Yuan, Jue, Zou, Wen-Quan, Haigh, Cathryn L.

“…Cardiomyopathy is a co-morbidity of some prion diseases including genetic disease caused by mutations within the PrP gene ( PRNP ). Although the cellular prion…”
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