Prognostic factors of worse outcome for hospitalized COVID-19 patients, with emphasis on chest computed tomography data: a retrospective study

To evaluate anthropometric and clinical data, muscle mass, subcutaneous fat, spine bone mineral density, extent of acute pulmonary disease related to COVID-19, quantification of pulmonary emphysema, coronary calcium, and hepatic steatosis using chest computed tomography of hospitalized patients with...

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Bibliographic Details
Published in:	Einstein (São Paulo, Brazil) Vol. 20; p. eAO6953
Main Authors:	do Amaral E Castro, Adham, Yokoo, Patrícia, Fonseca, Eduardo Kaiser Ururahy Nunes, Otoni, Jessyca Couto, Haiek, Sarah Lustosa, Shoji, Hamilton, Chate, Rodrigo Caruso, Pereira, Andrea Z, Queiroz, Marcos Roberto Gomes de, Batista, Marcelo Costa, Szarf, Gilberto
Format:	Journal Article
Language:	English
Published:	Brazil Instituto Israelita de Ensino e Pesquisa Albert Einstein 01-01-2022
Subjects:	Adult Calcium Coronavirus infections COVID-19 COVID-19 - diagnostic imaging Humans Lymphopenia MEDICINE, GENERAL & INTERNAL Multidetector computed tomography Obesity Original Pneumonia Prognosis Retrospective Studies Tomography Tomography, X-Ray Computed - methods X-ray computed COVID-19 Obesity Pneumonia Coronavirus infections Prognosis Tomography X-ray computed Multidetector computed tomography
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Summary:	To evaluate anthropometric and clinical data, muscle mass, subcutaneous fat, spine bone mineral density, extent of acute pulmonary disease related to COVID-19, quantification of pulmonary emphysema, coronary calcium, and hepatic steatosis using chest computed tomography of hospitalized patients with confirmed diagnosis of COVID-19 pneumonia and verify its association with disease severity. A total of 123 adults hospitalized due to COVID-19 pneumonia were enrolled in the present study, which evaluated the anthropometric, clinical and chest computed tomography data (pectoral and paravertebral muscle area and density, subcutaneous fat, thoracic vertebral bodies density, degree of pulmonary involvement by disease, coronary calcium quantification, liver attenuation measurement) and their association with poorer prognosis characterized through a combined outcome of intubation and mechanical ventilation, need of intensive care unit, and death. Age (p=0.013), body mass index (p=0.009), lymphopenia (p=0.034), and degree of pulmonary involvement of COVID-19 pneumonia (p<0.001) were associated with poor prognosis. Extent of pulmonary involvement by COVID-19 pneumonia had an odds ratio of 1,329 for a poor prognosis and a cutoff value of 6.5 for increased risk, with a sensitivity of 64.9% and specificity of 67.1%. The present study found an association of high body mass index, older age, extent of pulmonary involvement by COVID-19, and lymphopenia with severity of COVID-19 pneumonia in hospitalized patients.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 none. AUTHORS’ CONTRIBUTION Conflict of interest Adham do Amaral e Castro: conception and design of the work; data collection; data analysis and interpretation; draft of the article; critical revision of the article; final approval of the version to be published. Patrícia Yokoo: data collection; data analysis and interpretation; draft of the article; critical revision of the article; final approval of the version to be published. Eduardo Kaiser Ururahy Nunes Fonseca: data collection; data analysis and interpretation; critical revision of the article; final approval of the version to be published. Jessyca Couto Otoni: data collection; data analysis and interpretation; critical revision of the article; final approval of the version to be published. Sarah Lustosa Haiek: data collection; data analysis and interpretation; critical revision of the article; final approval of the version to be published. Hamilton Shoji: data collection; data analysis and interpretation; critical revision of the article; final approval of the version to be published. Rodrigo Caruso Chate: data collection; data analysis and interpretation; critical revision of the article; final approval of the version to be published. Andrea Z Pereira: data analysis and interpretation; critical revision of the article; final approval of the version to be published. Marcos Roberto Gomes de Queiroz: data analysis and interpretation; critical revision of the article; final approval of the version to be published. Marcelo Costa Batista: data analysis and interpretation; critical revision of the article; final approval of the version to be published. Gilberto Szarf: conception and design of the work; data analysis and interpretation; critical revision of the article; final approval of the version to be published.
ISSN:	1679-4508 2317-6385 2317-6385
DOI:	10.31744/einstein_journal/2022AO6953